Efficacy of the Echinocandin Caspofungin against Disseminated Aspergillosis and Candidiasis in Cyclophosphamide-Induced Immunosuppressed Mice

George K. Abruzzo; Charles J. Gill; Amy M. Flattery; Li Kong; Claire Leighton; Jeffrey G. Smith; V. Bill Pikounis; Ken Bartizal; Hugh Rosen

doi:10.1128/AAC.44.9.2310-2318.2000

DOI: 10.1128/AAC.44.9.2310-2318.2000

Article Information

DOI

https://doi.org/10.1128/AAC.44.9.2310-2318.2000

PubMed

10952573

Published By

American Society for Microbiology Journals

History

Received November 12, 1999
Returned for modification March 30, 2000
Accepted June 12, 2000
Published online September 1, 2000.

Author Information

George K. Abruzzo¹ *,
Charles J. Gill¹,
Amy M. Flattery¹,
Li Kong¹,
Claire Leighton¹,
Jeffrey G. Smith²,
V. Bill Pikounis³,
Ken Bartizal⁴ and
Hugh Rosen¹

Infectious Diseases,¹
Virus and Cell Biology,²
Biometrics Research,³ and
Animal Health,⁴ Merck Research Laboratories, Rahway, New Jersey 07065-0900

↵* Corresponding author. Mailing address: Infectious Diseases (RY80T-100), Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065-0900. Phone: (732) 594-6263. Fax: (732) 594-5700. E-mail: george_abruzzo{at}merck.com.

View Abstract

Article usage

Article usage: August 2000 to May 2020

Rendering graph...

	Abstract	Full	Pdf
Aug 2000	36	23	35
Sep 2000	110	29	14
Oct 2000	4	54	15
Nov 2000	8	76	18
Dec 2000	3	19	15
Jan 2001	13	32	25
Feb 2001	3	54	23
Mar 2001	8	39	50
Apr 2001	5	39	61
May 2001	5	30	38
Jun 2001	7	38	41
Jul 2001	6	27	47
Aug 2001	5	26	46
Sep 2001	5	30	48
Oct 2001	1	30	36
Nov 2001	3	17	35
Dec 2001	4	13	16
Jan 2002	6	22	30
Feb 2002	2	15	18
Mar 2002	2	12	17
Apr 2002	3	16	27
May 2002	2	28	26
Jun 2002	1	8	12
Jul 2002	6	23	21
Aug 2002	3	19	21
Sep 2002	16	22	20
Oct 2002	1	16	29
Nov 2002	4	17	10
Dec 2002	8	15	30
Jan 2003	10	23	31
Feb 2003	6	21	26
Mar 2003	7	31	43
Apr 2003	0	25	20
May 2003	3	23	19
Jun 2003	4	21	21
Jul 2003	4	20	20
Aug 2003	18	25	14
Sep 2003	11	24	20
Oct 2003	13	31	21
Nov 2003	12	32	21
Dec 2003	11	36	17
Jan 2004	22	31	18
Feb 2004	15	21	17
Mar 2004	13	39	20
Apr 2004	11	35	25
May 2004	18	37	10
Jun 2004	16	33	19
Jul 2004	23	31	8
Aug 2004	20	30	16
Sep 2004	19	30	13
Oct 2004	15	32	16
Nov 2004	15	28	16
Dec 2004	9	20	6
Jan 2005	12	21	20
Feb 2005	6	36	6
Mar 2005	5	22	13
Apr 2005	7	19	9
May 2005	11	28	12
Jun 2005	14	22	12
Jul 2005	9	10	4
Aug 2005	8	22	12
Sep 2005	8	21	5
Oct 2005	10	19	8
Nov 2005	7	14	9
Dec 2005	9	14	7
Jan 2006	8	29	17
Feb 2006	7	33	14
Mar 2006	7	16	7
Apr 2006	5	11	5
May 2006	8	15	4
Jun 2006	10	19	5
Jul 2006	7	10	9
Aug 2006	9	12	6
Sep 2006	7	14	7
Oct 2006	8	9	6
Nov 2006	12	12	6
Dec 2006	5	5	3
Jan 2007	5	7	4
Feb 2007	9	6	5
Mar 2007	15	8	8
Apr 2007	6	7	7
May 2007	4	7	8
Jun 2007	4	9	9
Jul 2007	8	4	3
Aug 2007	12	12	6
Sep 2007	2	5	1
Oct 2007	9	12	5
Nov 2007	6	15	10
Dec 2007	4	9	6
Jan 2008	12	9	13
Feb 2008	10	3	10
Mar 2008	7	8	8
Apr 2008	8	3	2
May 2008	11	16	8
Jun 2008	19	7	2
Jul 2008	14	4	1
Aug 2008	9	7	5
Sep 2008	21	7	6
Oct 2008	7	5	6
Nov 2008	13	11	4
Dec 2008	13	11	5
Jan 2009	22	3	3
Feb 2009	16	6	6
Mar 2009	16	14	7
Apr 2009	13	10	7
May 2009	11	6	2
Jun 2009	8	7	3
Jul 2009	6	3	3
Aug 2009	5	5	4
Sep 2009	11	7	6
Oct 2009	24	6	7
Nov 2009	15	3	3
Dec 2009	6	9	6
Jan 2010	11	9	9
Feb 2010	13	6	2
Mar 2010	5	6	3
Apr 2010	11	1	1
May 2010	13	3	4
Jun 2010	12	1	6
Jul 2010	13	6	8
Aug 2010	10	3	7
Sep 2010	14	8	4
Oct 2010	10	6	8
Nov 2010	12	3	5
Dec 2010	16	3	4
Jan 2011	11	4	3
Feb 2011	10	7	5
Mar 2011	16	6	10
Apr 2011	20	5	5
May 2011	15	5	9
Jun 2011	13	5	8
Jul 2011	19	7	10
Aug 2011	11	6	6
Sep 2011	20	5	11
Oct 2011	15	5	10
Nov 2011	11	7	9
Dec 2011	21	5	10
Jan 2012	27	12	15
Feb 2012	14	6	11
Mar 2012	10	13	8
Apr 2012	10	4	9
May 2012	17	4	7
Jun 2012	14	2	9
Jul 2012	13	4	9
Aug 2012	18	3	9
Sep 2012	15	3	7
Oct 2012	23	5	9
Nov 2012	22	4	14
Dec 2012	17	3	4
Jan 2013	21	11	11
Feb 2013	10	4	4
Mar 2013	13	5	5
Apr 2013	36	10	7
May 2013	17	8	8
Jun 2013	16	3	6
Jul 2013	27	10	8
Aug 2013	11	3	4
Sep 2013	9	5	3
Oct 2013	16	8	5
Nov 2013	12	4	3
Dec 2013	11	0	2
Jan 2014	13	9	5
Feb 2014	19	3	10
Mar 2014	28	6	5
Apr 2014	25	18	5
May 2014	16	9	5
Jun 2014	10	14	10
Jul 2014	20	14	8
Aug 2014	13	8	1
Sep 2014	9	6	6
Oct 2014	8	7	3
Nov 2014	11	19	7
Dec 2014	8	13	4
Jan 2015	11	11	7
Feb 2015	12	5	4
Mar 2015	17	5	8
Apr 2015	11	5	4
May 2015	13	2	6
Jun 2015	19	2	2
Jul 2015	13	4	6
Aug 2015	18	7	1
Sep 2015	19	9	10
Oct 2015	15	9	14
Nov 2015	18	2	6
Dec 2015	15	4	1
Jan 2016	19	5	9
Feb 2016	15	1	3
Mar 2016	15	0	9
Apr 2016	13	3	4
May 2016	15	9	9
Jun 2016	13	9	4
Jul 2016	6	4	4
Aug 2016	8	2	3
Sep 2016	6	2	3
Oct 2016	29	5	5
Nov 2016	30	5	8
Dec 2016	7	4	3
Jan 2017	7	5	7
Feb 2017	4	5	2
Mar 2017	9	2	2
Apr 2017	10	3	2
May 2017	14	6	5
Jun 2017	19	3	3
Jul 2017	9	3	5
Aug 2017	9	4	3
Sep 2017	12	4	3
Oct 2017	8	3	2
Nov 2017	13	5	7
Dec 2017	2	0	2
Jan 2018	15	3	11
Feb 2018	12	2	6
Mar 2018	17	4	9
Apr 2018	15	4	5
May 2018	11	5	5
Jun 2018	9	2	6
Jul 2018	13	1	5
Aug 2018	10	9	4
Sep 2018	7	13	11
Oct 2018	0	12	2
Nov 2018	5	14	14
Dec 2018	6	8	7
Jan 2019	4	4	4
Feb 2019	4	6	6
Mar 2019	4	7	7
Apr 2019	3	11	10
May 2019	2	9	7
Jun 2019	4	4	7
Jul 2019	3	6	8
Aug 2019	4	6	10
Sep 2019	2	6	4
Oct 2019	1	12	7
Nov 2019	4	17	10
Dec 2019	4	8	18
Jan 2020	3	21	6
Feb 2020	3	12	6
Mar 2020	0	4	6
Apr 2020	2	17	5
May 2020	3	21	4