DOI: 10.1128/AAC.45.1.303-305.2001
Article Figures & Data
Figures
- Fig. 1.
Light micrograph of chlamydial inclusions growing in McCoy cells and stained with fluorescein isothiocyanate-labeled monoclonal antibody to the chlamydial lipopolysaccharide. Chlamydiae were treated with 0.25 μg of mecillinam per ml (a) or no antibiotic (PBS control) (b). The typical appearance of the β-lactam form can be seen in panel a, compared to a normal inclusion in panel b. Magnification, ×3,200.
- Fig. 2.
Fluorogram showing the competition of meropenem for the PBPs of C. trachomatis.
Tables
- Table 1.
Antichlamydial activities of selected penicillins, cephalosporins, and carbapenems and their competition for the PBPs of C. trachomatis
Antibiotic MIC (μg/ml) MBC (μg/ml) IC50 (μg/ml) for PBP binding PBP1 PBP2 PBP3 Benzylpenicillin 0.1 4.0 0.03 0.005 0.01 Ampicillin 0.1 2.0 0.01 0.005 0.5 Mecillinam 0.1 0.25 0.2 100 250 Ceftriaxone 2.0 16.0 0.1 0.01 1.0 Cefotaxime 32.0 250 0.1 0.04 5.0 Imipenem 64 512 0.01 0.2 0.005 Meropenem 16 64 0.01 0.1 0.005
