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Mechanisms of Action: Physiological Effects

Affinities of β-Lactams for Penicillin Binding Proteins of Chlamydia trachomatis and Their Antichlamydial Activities

Christopher Storey, Ian Chopra
Christopher Storey
Division of Microbiology and Antimicrobial Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom
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Ian Chopra
Division of Microbiology and Antimicrobial Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom
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DOI: 10.1128/AAC.45.1.303-305.2001
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    Fig. 1.

    Light micrograph of chlamydial inclusions growing in McCoy cells and stained with fluorescein isothiocyanate-labeled monoclonal antibody to the chlamydial lipopolysaccharide. Chlamydiae were treated with 0.25 μg of mecillinam per ml (a) or no antibiotic (PBS control) (b). The typical appearance of the β-lactam form can be seen in panel a, compared to a normal inclusion in panel b. Magnification, ×3,200.

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    Fig. 2.

    Fluorogram showing the competition of meropenem for the PBPs of C. trachomatis.

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    Antichlamydial activities of selected penicillins, cephalosporins, and carbapenems and their competition for the PBPs of C. trachomatis

    AntibioticMIC (μg/ml)MBC (μg/ml)IC50 (μg/ml) for PBP binding
    PBP1PBP2PBP3
    Benzylpenicillin0.14.00.030.0050.01
    Ampicillin0.12.00.010.0050.5
    Mecillinam0.10.250.2100250
    Ceftriaxone2.016.00.10.011.0
    Cefotaxime32.02500.10.045.0
    Imipenem645120.010.20.005
    Meropenem16640.010.10.005
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Affinities of β-Lactams for Penicillin Binding Proteins of Chlamydia trachomatis and Their Antichlamydial Activities
Christopher Storey, Ian Chopra
Antimicrobial Agents and Chemotherapy Jan 2001, 45 (1) 303-305; DOI: 10.1128/AAC.45.1.303-305.2001

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Affinities of β-Lactams for Penicillin Binding Proteins of Chlamydia trachomatis and Their Antichlamydial Activities
Christopher Storey, Ian Chopra
Antimicrobial Agents and Chemotherapy Jan 2001, 45 (1) 303-305; DOI: 10.1128/AAC.45.1.303-305.2001
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KEYWORDS

Anti-Bacterial Agents
Bacterial Proteins
Carrier Proteins
Chlamydia trachomatis
Hexosyltransferases
Muramoylpentapeptide Carboxypeptidase
Peptidyl Transferases

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