In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus andFusarium Isolates

DOI: 10.1128/AAC.45.1.327-330.2001

Article Figures & Data

Table 1.

MIC and MEC values obtained in RPMI after 24, 48, and 72 h of incubation

Species (n)	Incubation period (h)	MIC (μg/ml)		MEC (μg/ml)
Species (n)	Incubation period (h)	GM	Range	GM	Range
A. flavus (27)	24	2.72	0.25–>16	0.27	0.25–0.5
	48	4	0.25–>16	0.31	0.25–0.5
	72	>16	>16	0.26	0.25–0.5
A. fumigatus (26)	24	0.73	0.25–>16	0.29	0.25–0.5
	48	27.7	0.25–>16	0.3	0.25–0.5
	72	17.45	0.25–>16	0.28	0.25–0.5
A. niger (17)	24	0.41	0.25–1	0.41	0.25–1
	48	0.44	0.25–2	0.42	0.25–1
	72	1.28	0.25–>16	0.42	0.25–0.5
A. terreus (9)	24	0.5	0.5	0.5	0.5
	48	0.5	0.5	0.5	0.5
	72	8.64	0.5–>16	0.5	0.5
A. nidulans (3)	24^a
	48	0.63	0.5–1	0.5	0.5
	72	0.63	0.5–1	0.5	0.5
F. solani (18)	24	22.6	16–>16	17.3	8–>16
	48	30.79	16–>16	27.43	16–>16
	72	>16	>16	30.8	16–>16
F. oxysporum (4)	24	16	16	19	16–>16
	48	>16	>16	>16	>16
	72	>16	>16	>16	>16

Table 2.

MIC and MEC values obtained in RPMI-2 after 24, 48, and 72 h of incubation

Species (n)	Incubation period (h)	MIC (μg/ml)		MEC (μg/ml)
Species (n)	Incubation period (h)	GM	Range	GM	Range
A. flavus (27)	24	3.17	0.25–>16	0.33	0.25–0.5
	48	4	0.25–>16	0.34	0.25–0.5
	72	>16	>16	0.34	0.25–0.5
A. fumigatus (26)	24	1.89	0.25–>16	0.31	0.25–0.5
	48	26.9	0.5–>16	0.31	0.25–0.5
	72	>16	0.5–>16	0.29	0.25–0.5
A. niger (17)	24	0.54	0.5–1	0.52	0.5–1
	48	0.64	0.5–2	0.54	0.5–1
	72	0.78	0.5–>16	0.54	0.5
A. terreus (9)	24	0.5	0.5	0.5	0.5
	48	1.26	0.5–>16	0.5	0.5
	72	8	0.5–>16	0.5	0.5
A. nidulans (3)	24^a
	48	0.5	0.5	0.5	0.5
	72	0.5	0.5	0.5	0.5
F. solani (18)	24	24.4	16–>16	22.63	8–>16
	48	>16	>16	28.51	16–>16
	72	>16	>16	>16	>16
F. oxysporum (4)	24	16	16	19.03	16–>16
	48	>16	>16	>16	>16
	72	>16	>16	>16	>16

Table 3.

MIC and MEC values obtained in AM3 after 24, 48, and 72 h of incubation

Species (n)	Incubation period (h)	MIC (μg/ml)		MEC (μg/ml)
Species (n)	Incubation period (h)	GM	Range	GM	Range
A. flavus (27)	24	2.27	0.125–>16	0.26	0.125–0.5
	48	3.7	0.125–>16	0.26	0.125–0.5
	72	>16	>16	0.26	0.125–0.5
A. fumigatus (26)	24	0.43	0.25–>16	0.31	0.25–0.5
	48	2.83	0.25–>16	0.31	0.25–0.5
	72	17.4	0.25–>16	0.31	0.25–0.5
A. niger (17)	24	0.23	0.125–1	0.2	0.125–0.25
	48	0.26	0.125–0.5	0.2	0.125–0.25
	72	0.32	0.25–1	0.27	0.25–0.5
A. terreus (9)	24	0.25	0.25	0.25	0.25
	48	0.25	0.25	0.25	0.25
	72	1.26	0.25–>16	0.25	0.25
A. nidulans (3)	24^a
	48	0.25	0.25	0.25	0.25
	72	0.25	0.25	0.25	0.25
F. solani (18)	24	19.4	16–>16	16.63	4–>16
	48	26.4	16–>16	26.4	16–>16
	72	>16	>16	>16	>16
F. oxysporum(4)	24	16	16	16	16
	48	26.91	16–>16	26.91	16–>16
	72	>16	>16	>16	>16