Antimicrobial Agents and Chemotherapy: 45 (11)

November 1, 2001; Volume 45,Issue 11

Minireviews

Minireview
Use of Aminoglycosides in Treatment of Infections Due to Intracellular Bacteria
M. Maurin, D. Raoult

Guest Commentary

GUEST COMMENTARY
Critical Annotations to the Use of Azole Antifungals for Plant Protection
Herbert Hof

Mechanisms of Resistance

Mechanisms of Resistance
Molecular Analysis of Antibiotic Resistance Gene Clusters in Vibrio cholerae O139 and O1 SXT Constins
Bianca Hochhut, Yasmin Lotfi, Didier Mazel, Shah M. Faruque, Roger Woodgate, Matthew K. Waldor
Mechanisms of Resistance
Family of Class 1 Integrons Related to In4 from Tn1696
Sally R. Partridge, Gavin D. Recchia, H. W. Stokes, Ruth M. Hall
Mechanisms of Resistance
In Vitro and In Vivo Effects of 14α-Demethylase (ERG11) Depletion in Candida glabrata
Hironobu Nakayama, Noboru Nakayama, Mikio Arisawa, Yuko Aoki
Mechanisms of Resistance
Rifampin Resistance in Mycobacterium kansasii Is Associated with rpoB Mutations
John L. Klein, Timothy J. Brown, Gary L. French
Mechanisms of Resistance
Role of Penicillin-Binding Protein 4 in Expression of Vancomycin Resistance among Clinical Isolates of Oxacillin-ResistantStaphylococcus aureus
J. E. Finan, Gordon L. Archer, Michael J. Pucci, Michael W. Climo
Mechanisms of Resistance
Association of Genetic Mutations inPlasmodium vivax dhfr with Resistance to Sulfadoxine-Pyrimethamine: Geographical and Clinical Correlates
Mallika Imwong, Sasithon Pukrittakayamee, Sornchai Looareesuwan, Geoffrey Pasvol, Jean Poirreiz, Nicholas J. White, Georges Snounou
Mechanisms of Resistance
Quinolone Resistance Mutations in Streptococcus pneumoniae GyrA and ParC Proteins: Mechanistic Insights into Quinolone Action from Enzymatic Analysis, Intracellular Levels, and Phenotypes of Wild-Type and Mutant Proteins
Xiao-Su Pan, Genoveva Yague, L. Mark Fisher
Mechanisms of Resistance
Reversal of Chloroquine Resistance inPlasmodium falciparum Using Combinations of Chemosensitizers
Donelly A. van Schalkwyk, Jason C. Walden, Peter J. Smith
Mechanisms of Resistance
Cloning and Biochemical Characterization of FOX-5, an AmpC-Type Plasmid-Encoded β-Lactamase from a New York CityKlebsiella pneumoniae Clinical Isolate
Anne Marie Queenan, Stephen Jenkins, Karen Bush
Mechanisms of Resistance
Genetic Analysis of Multiple Loci Suggests that Mutations in the Pneumocystis carinii f. sp.hominis Dihydropteroate Synthase Gene Arose Independently in Multiple Strains
Liang Ma, Joseph A. Kovacs
Mechanisms of Resistance
Indication of Transposition of a Mobile DNA Element Containing the vat(D) and erm(B) Genes inEnterococcus faecium
Anette M. Hammerum, Susan E. Flannagan, Don B. Clewell, Lars Bogø Jensen
Mechanisms of Resistance
Novel Tetracycline Resistance Gene,tet(32), in the Clostridium-Related Human Colonic Anaerobe K10 and Its Transmission In Vitro to the Rumen Anaerobe Butyrivibrio fibrisolvens
Claire M. Melville, Karen P. Scott, Derry K. Mercer, Harry J. Flint
Mechanisms of Resistance
Aminoglycoside-Streptothricin Resistance Gene Cluster aadE–sat4–aphA-3 Disseminated among Multiresistant Isolates of Enterococcus faecium
Guido Werner, Bianca Hildebrandt, Wolfgang Witte
Mechanisms of Resistance
Staphylococcus aureus Mutants Selected by BMS-284756
L. F. Discotto, L. E. Lawrence, K. L. Denbleyker, J. F. Barrett

Susceptibility

Susceptibility
Effects of Azithromycin and Rifampin onChlamydia trachomatis Infection In Vitro
Ute Dreses-Werringloer, Ingrid Padubrin, Henning Zeidler, Lars Köhler
Susceptibility
In Vitro Antimicrobial Activities of Bakuchiol against Oral Microorganisms
Harumi Katsura, Ryo-Ichi Tsukiyama, Akiko Suzuki, Makio Kobayashi
Susceptibility
Trends in Antifungal Drug Susceptibility of Cryptococcus neoformans Isolates in the United States: 1992 to 1994 and 1996 to 1998
Mary E. Brandt, Michael A. Pfaller, Rana A. Hajjeh, Richard J. Hamill, Peter G. Pappas, Arthur L. Reingold, David Rimland, David W. Warnock
and for the Cryptococcal Disease Active Surveillance Group
Susceptibility
Emergence of Reduced Susceptibility and Resistance to Fluoroquinolones in Escherichia coliin Taiwan and Contributions of Distinct Selective Pressures
L. Clifford McDonald, Feng-Jui Chen, Hsiu-Jung Lo, Hsiao-Chuan Yin, Po-Liang Lu, Cheng-Hua Huang, Pei Chen, Tsai-Ling Lauderdale, Monto Ho
Susceptibility
Antibacterial Activities and Pharmacokinetics of E-4767 and E-5065, Two New 8-Chlorofluoroquinolones with a 7-Azetidin Ring Substituent
Domingo Gargallo-Viola, Santiago Ferrer, Encarna Tudela, Marta Robert, Ramon Coll, Roberto Roser, Jesus Guinea
Susceptibility
Antifungal Activities and Cytotoxicity Studies of Six New Azasordarins
Esperanza Herreros, Maria Jesus Almela, Sonia Lozano, Federico Gomez De Las Heras, Domingo Gargallo-Viola
Susceptibility
In Vitro Anti-Helicobacter pyloriActivity of the Probiotic Strain Bacillus subtilis 3 Is Due to Secretion of Antibiotics
Irina V. Pinchuk, Philippe Bressollier, Bernard Verneuil, Bernard Fenet, Irina B. Sorokulova, Francis Mégraud, Maria C. Urdaci
Susceptibility
Analysis of Antimalarial Synergy between Bestatin and Endoprotease Inhibitors Using Statistical Response-Surface Modelling
Clare S. Gavigan, Stella G. Machado, John P. Dalton, Angus Bell
Susceptibility
Marked Potentiation of Activity of β-Lactams against Methicillin-Resistant Staphylococcus aureus by Corilagin
Masato Shimizu, Sumiko Shiota, Tohru Mizushima, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya
Susceptibility
High Incidence of Erythromycin Resistance among Clinical Isolates of Streptococcus agalactiae in Taiwan
Po-Ren Hsueh, Lee-Jene Teng, Li-Na Lee, Shen-Wu Ho, Pan-Chyr Yang, Kwen-Tay Luh
Susceptibility
In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides
Gudmundur Bergsson, Jóhann Arnfinnsson, Ólafur Steingrı́msson, Halldor Thormar
Susceptibility
Susceptibilities of Oral Bacteria and Yeast to Mammalian Cathelicidins
Janet M. Guthmiller, Kaaren G. Vargas, Rupasree Srikantha, Lori L. Schomberg, Paula L. Weistroffer, Paul B. McCray, Brian F. Tack
Susceptibility
Synergistic Activities of Gatifloxacin in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa and Related Species
Elizabeth Gradelski, Lourdes Valera, Daniel Bonner, Joan Fung-Tomc
Susceptibility
Antimicrobial Susceptibilities of 1,730Haemophilus influenzae Respiratory Tract Isolates in Spain in 1998-1999
Francesc Marco, Juan Garcı́a-de-Lomas, César Garcı́a-Rey, Emilio Bouza, Lorenzo Aguilar, Carlos Fernández-Mazarrasa, The Spanish Surveillance Group for Respiratory Pathogens†
Susceptibility
Activities of a New Fluoroketolide, HMR 3787, and Its (Des)-Fluor Derivative RU 64399 Compared to Those of Telithromycin, Erythromycin A, Azithromycin, Clarithromycin, and Clindamycin against Macrolide-Susceptible or -Resistant Streptococcus pneumoniae and S. pyogenes
Kensuke Nagai, Todd A. Davies, Lois M. Ednie, Andre Bryskier, Elizabeth Palavecino, Michael R. Jacobs, Peter C. Appelbaum
Susceptibility
Susceptibilities of Eikenella corrodens,Prevotella intermedia, and Prevotella nigrescensClinical Isolates to Amoxicillin and Tetracycline
N. Luong, J. Tsai, C. Chen
Susceptibility
In Vitro and In Vivo Activities of Sitafloxacin againstChlamydia spp
Naoyuki Miyashita, Yoshihito Niki, Toshiharu Matsushima
Susceptibility
In Vitro Susceptibility of Coxiella burnetii to Linezolid in Comparison with Its Susceptibilities to Quinolones, Doxycycline, and Clarithromycin
Achilleas Gikas, Ioanna Spyridaki, Efstathia Scoulica, Anna Psaroulaki, Yannis Tselentis

Antiviral Agents

Antiviral Agents
DPC 681 and DPC 684: Potent, Selective Inhibitors of Human Immunodeficiency Virus Protease Active against Clinically Relevant Mutant Variants
Robert F. Kaltenbach, George Trainor, Daniel Getman, Greg Harris, Sena Garber, Beverly Cordova, Lee Bacheler, Susan Jeffrey, Kelly Logue, Pamela Cawood, Ronald Klabe, Sharon Diamond, Marc Davies, Joanne Saye, Janan Jona, Susan Erickson-Viitanen

Pharmacology

Pharmacology
Development and Validation of Limited-Sampling Strategies for Predicting Amoxicillin Pharmacokinetic and Pharmacodynamic Parameters
Guilherme Suarez-Kurtz, Frederico Mota Ribeiro, Flávio L. Vicente, Claudio J. Struchiner
Pharmacology
Bronchopulmonary Disposition of the Ketolide Telithromycin (HMR 3647)
Claudette Muller-Serieys, Paul Soler, Cathy Cantalloube, Françoise Lemaitre, Hai Pham Gia, Françoise Brunner, Antoine Andremont
Pharmacology
Pharmacokinetics of Cefepime during Continuous Renal Replacement Therapy in Critically Ill Patients
Rebecca S. Malone, Douglas N. Fish, Edward Abraham, Isaac Teitelbaum
Pharmacology
Rifampin Reduces Concentrations of Trimethoprim and Sulfamethoxazole in Serum in Human Immunodeficiency Virus-Infected Patients
Esteban Ribera, Leonor Pou, Antoni Fernandez-Sola, Francisco Campos, Rosa M. Lopez, Imma Ocaña, Isabel Ruiz, Albert Pahissa

Analytical Procedures

Analytical Procedures
Single Ribosomal Protein Mutations in Antibiotic-Resistant Bacteria Analyzed by Mass Spectrometry
Sheri K. Wilcox, Gregory S. Cavey, James D. Pearson

Mechanisms of Action

Mechanisms of Action: Physiological Effects
Clearance of Infection with Mycobacterium bovis BCG in Mice Is Enhanced by Treatment with S28463 (R-848), and Its Efficiency Depends on Expression of Wild-Type Nramp1 (Resistance Allele)
Jacques Moisan, Wojciech Wojciechowski, Claudine Guilbault, Claude Lachance, Sergio Di Marco, Emil Skamene, Greg Matlashewski, Danuta Radzioch
Mechanisms of Action: Physiological Effects
ATP Synthase Is Necessary for Microcin H47 Antibiotic Action
Mónica Trujillo, Eliana Rodrı́guez, Magela Laviña
Mechanisms of Action: Physiological Effects
Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR
M. Cristina Cruz, Alan L. Goldstein, Jill Blankenship, Maurizio Del Poeta, John R. Perfect, John H. McCusker, Youssef L. Bennani, Maria E. Cardenas, Joseph Heitman
Mechanisms of Action: Physiological Effects
Identification and Characterization of New Inhibitors of the Escherichia coli MurA Enzyme
Ellen Z. Baum, Deborah A. Montenegro, Lisa Licata, Ignatius Turchi, Glenda C. Webb, Barbara D. Foleno, Karen Bush
Mechanisms of Action: Physiological Effects
Fungal Phospholipase Activity and Susceptibility to Lipid Preparations of Amphotericin B
Magnus Gottfredsson, Chad J. Jessup, Gary M. Cox, John R. Perfect, Mahmoud A. Ghannoum
Mechanisms of Action: Physiological Effects
Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells
V. C. Kalfa, H. P. Jia, R. A. Kunkle, P. B. McCray, B. F. Tack, K. A. Brogden
Mechanisms of Action: Physiological Effects
Eradication of Biofilm-Forming Staphylococcus epidermidis (RP62A) by a Combination of Sodium Salicylate and Vancomycin
Roy E. Polonio, Leonard A. Mermel, Gregory E. Paquette, Jay F. Sperry

Experimental Therapeutics

Experimental Therapeutics
Efficacies of Moxifloxacin, Ciprofloxacin, and Vancomycin against Experimental Endocarditis Due to Methicillin-ResistantStaphylococcus aureus Expressing Various Degrees of Ciprofloxacin Resistance
J. M. Entenza, Y. A. Que, J. Vouillamoz, M. P. Glauser, P. Moreillon
Experimental Therapeutics
Pharmacodynamics and Bactericidal Activity of Moxifloxacin in Experimental Escherichia coliMeningitis
Violeta Rodriguez-Cerrato, Cynthia C. McCoig, Ian C. Michelow, Faryal Ghaffar, Hasan S. Jafri, Robert D. Hardy, Chetan Patel, Kurt Olsen, George H. McCracken
Experimental Therapeutics
BMS-284756 in Experimental Cephalosporin-Resistant Pneumococcal Meningitis
Violeta Rodriguez-Cerrato, Faryal Ghaffar, Jesus Saavedra, Ian C. Michelow, Robert D. Hardy, Janie Iglehart, Kurt Olsen, George H. McCracken
Experimental Therapeutics
Activities of New Macrolides and Fluoroquinolones against Mycobacterium ulcerans Infection in Mice
Abdelhalim Bentoucha, Jérôme Robert, Hervé Dega, Nacer Lounis, Vincent Jarlier, Jacques Grosset
Experimental Therapeutics
New Model of Oropharyngeal Candidiasis in Mice
Yasuki Kamai, Mikie Kubota, Yoko Kamai, Tsunemichi Hosokawa, Takashi Fukuoka, Scott G. Filler
Experimental Therapeutics
Efficacies of Clarithromycin Regimens against Mycobacterium xenopi in Mice
Nacer Lounis, Chantal Truffot-Pernot, Abdelhalim Bentoucha, Jerome Robert, Baohong Ji, Jacques Grosset
Experimental Therapeutics
In Vitro and In Vivo Effects of Quinupristin-Dalfopristin against Pneumocystis carinii
Peter D. Walzer, Alan Ashbaugh, Margaret Collins, Melanie T. Cushion
Experimental Therapeutics
In Vivo Efficacy of Telithromycin (HMR3647) againstStreptococcus pneumoniae and Haemophilus influenzae
Hiroki Okamoto, Shuichi Miyazaki, Kazuhiro Tateda, Yoshikazu Ishii, Keizo Yamaguchi

Clinical Therapeutics

Clinical Therapeutics
Treatment of Vancomycin-Resistant Enterococcal Infections in the Immunocompromised Host: Quinupristin-Dalfopristin in Combination with Minocycline
Issam Raad, Ray Hachem, Hend Hanna, Essam Girgawy, Kenneth Rolston, Estella Whimbey, Rola Husni, Gerald Bodey

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Table of Contents

Minireviews

Guest Commentary

Mechanisms of Resistance

Susceptibility

Antiviral Agents

Pharmacology

Analytical Procedures

Mechanisms of Action

Experimental Therapeutics

Clinical Therapeutics

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