DOI: 10.1128/AAC.45.12.3585-3590.2001
Article Figures & Data
Figures
- Fig. 1.
Logarithmic plots of the median plasma concentration-time profiles of d4T and ddI in infants at 14 and 28 days of age. Each datum point represents the plasma drug concentration at a specific time point for each infant.
Tables
- Table 1.
Baseline characteristics of mothers and infants
Characteristic Value(s) Maternal age (yr) 25.6 ± 4.7a Maternal CDCbclassification for HIV (no. of subjects) A 7 B 1 Duration of prenatal ZDV use, days 75.5 (49.0–157.0)c No. of ZDV doses during labor 2 (0–7)c Duration of membrane rupture before birth (min) 18 (0–412)c Mode of delivery (no. of subjects) Vaginal delivery 6 Cesarean delivery 2 Obstetric complication, fetal distress (no. of subjects) 1 Infant's gender (no. of infants) Male 4 Female 4 Infant's birth wt (kg) 3.3 ± 0.3a Infant's gestational age (wk) 38.9 ± 2.0a - Table 2.
Pharmacokinetic parameters of d4T and ddI in newborn infantsa
Drug and age (days) Cmax(ng/ml) Tmax (h) AUC0–12(ng · h/ml) AUC0–∞ (ng · h/ml) Half-life (h) d4T 14 463 (335–582, 17.5) 2.5 (1.0–2.5, 40.1) 1,866 (1,286–2,420, 22.6) 1,930 (1,369–2,461, 21.9) 1.8 (1.2–2.0, 17.6) 28 507 (337–589, 20.6) 2.5 (1.0–2.5, 32.7) 1,603 (1,107–1,986, 24.5) 1,890 (1,126–2,010, 23.2)b 1.4 (1.2–1.8, 13.5)b ddI 14 627 (168–786, 38.9) 1.3 (0.5–2.0, 64.1) 1,573 (451–2,327, 39.3)d 1,595 (464–2,332, 43.8)c 1.2 (0.9–1.4, 14.8)c 28 687 (208–982, 46.3) 1.0 (0.5–2.0, 63.4) 1,562 (776–2,270, 41.1)d 1,856 (782–2,327, 43.6)b 1.1 (0.5–1.5, 30.8)b ↵a The values are medians (ranges, coefficients of variation, with coefficients of variation presented as percentages).
↵b The value was undetermined in an infant due to insufficient datum points in the terminal elimination phase.
↵c The values were undetermined in two infants due to insufficient datum points in the terminal elimination phase.
↵d For ddI, values are AUC0–10.
