Streptococcus pneumoniae Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Clonal Diversity and Appearance of Ciprofloxacin-Resistant Epidemic Clones

Molecular Genetics Laboratory, Instituto de Tecnologia Quı́mica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Microbiology Department, School of Medicine, Universidad Complutense, and Medical Department, GlaxoSmithKline Pharmaceuticals, Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York

Molecular Genetics Laboratory, Instituto de Tecnologia Quı́mica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Microbiology Department, School of Medicine, Universidad Complutense, and Medical Department, GlaxoSmithKline Pharmaceuticals, Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York

Molecular Genetics Laboratory, Instituto de Tecnologia Quı́mica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Microbiology Department, School of Medicine, Universidad Complutense, and Medical Department, GlaxoSmithKline Pharmaceuticals, Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York

Molecular Genetics Laboratory, Instituto de Tecnologia Quı́mica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Microbiology Department, School of Medicine, Universidad Complutense, and Medical Department, GlaxoSmithKline Pharmaceuticals, Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York

Molecular Genetics Laboratory, Instituto de Tecnologia Quı́mica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Microbiology Department, School of Medicine, Universidad Complutense, and Medical Department, GlaxoSmithKline Pharmaceuticals, Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York