Article Figures & Data
Figures
- Fig. 1.
Mean concentrations of amphotericin B given as ABCD or AMB in the CSF of two rabbits each after a single dose (A and B) or four doses (C and D). Dosages were as given in the figure. The arrows in panels C and D indicate the times of dosing.
Tables
- Table 1.
Signs and symptoms of neurological effects observed in rabbits given AMB or ABCD intrathecallya
Drug and concn (mg/kg) Hyperthermia or hypothermia Weight loss Mobility problem Convulsion or tremor Paresis or paralysis SD MD SD MD SD MD SD MD SD MD ABCD 0.0015 −/− −/− +/− +/− −/− −/− −/− −/− −/− −/− 0.015 −/− −/− −/− +/+ −/− +/+ −/− −/− −/− −/− 0.045 +/− −/− −/− −/− −/− −/− −/− −/− −/− −/− 0.135* +/− +/+ +/− +/+ +/+ +/+ −/− +/− +/− +/+ AMB 0.0015 −/− −/− +/− −/− +/− −/− −/− −/− −/− −/− 0.015 +/+ +/+ +/+ +/− +/+ +/+ −/− +/+ −/− +/+ 0.045 +/− +/+ +/− +/+ +/− 0.135 +/+ +/− +/+ +/− +/− ↵a SD indicates results from the single-dose study, and MD indicates results from the multiple-dose study. A + indicates that these signs and symptoms occurred at some point for that rabbit during the study. A +/+ indicates that they occurred in both rabbits, +/− indicates the only one rabbit of the two showed that sign or symptom sign, and −/− indicates that neither rabbit showed that sign or symptom. ∗, animals died or were euthanatized 24 h after 2nd or 3rd dose.
