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Mechanisms of Resistance

Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-ResistantStreptococcus pneumoniae

Jeffrey P. Maskell, Armine M. Sefton, Lucinda M. C. Hall
Jeffrey P. Maskell
Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London E1 2AD, United Kingdom
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Armine M. Sefton
Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London E1 2AD, United Kingdom
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Lucinda M. C. Hall
Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London E1 2AD, United Kingdom
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DOI: 10.1128/AAC.45.4.1104-1108.2001
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Article Information

DOI 
https://doi.org/10.1128/AAC.45.4.1104-1108.2001
PubMed 
11257022

Published By 
American Society for Microbiology Journals
History 
  • Received August 8, 2000
  • Returned for modification November 12, 2000
  • Accepted January 12, 2001
  • Published online April 1, 2001.

Copyright & Usage 
Copyright © 2001 American Society for Microbiology

Author Information

  1. Jeffrey P. Maskell*,
  2. Armine M. Sefton and
  3. Lucinda M. C. Hall
  1. Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London E1 2AD, United Kingdom
  • ↵* Corresponding author. Mailing address: Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Turner St., Whitechapel, London E1 2AD, United Kingdom. Phone: (44) 020 7377 7257. Fax: (44) 020 7375 0518. E-mail:J.Maskell{at}mds.qmw.ac.uk.

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Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-ResistantStreptococcus pneumoniae
Jeffrey P. Maskell, Armine M. Sefton, Lucinda M. C. Hall
Antimicrobial Agents and Chemotherapy Apr 2001, 45 (4) 1104-1108; DOI: 10.1128/AAC.45.4.1104-1108.2001

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Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-ResistantStreptococcus pneumoniae
Jeffrey P. Maskell, Armine M. Sefton, Lucinda M. C. Hall
Antimicrobial Agents and Chemotherapy Apr 2001, 45 (4) 1104-1108; DOI: 10.1128/AAC.45.4.1104-1108.2001
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KEYWORDS

Anti-Infective Agents, Urinary
mutation
Streptococcus pneumoniae
Tetrahydrofolate Dehydrogenase
trimethoprim

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