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- Table 1.
Susceptibilities of 5,558 clinical isolates to ertapenem and three comparator drugs
Microorganism(s) (no. of isolates) and antimicrobial agentb MIC (μg/ml) Range 50% 90% Acinetobacterspp.a(86) Ertapenem 0.06–>16 4.0 16 Imipenem ≤0.008–>16 0.25 2.0 Amox-clav 0.06–>32 16 >32 Ciprofloxacin ≤0.008–>16 1.0 >16 Aeromonas spp.c(21) Ertapenem 0.03–1.0 0.06 0.25 Imipenem 0.25–4.0 0.5 2.0 Amox-clav 16–>32 32 >32 Ciprofloxacin ≤0.008–1.0 0.016 0.12 Burkholderia cepacia(13) Ertapenem 4.0–>16 8.0 >16 Imipenem 8.0–>16 16 >16 Amox-clav 32–32 >32 >32 Ciprofloxacin 1.0–>16 4.0 >16 Citrobacter spp.d(216) Ertapenem ≤0.008–4.0 ≤0.008 0.25 Imipenem 0.06–2.0 0.5 1.0 Amox-clav 2.0–>32 16 >32 Ciprofloxacin ≤0.008–>16 0.03 1.0 Enterobacter spp.e(239) Ertapenem ≤0.008–>16 0.03 0.5 Imipenem 0.12–>16 1.0 2.0 Amox-clav 1.0–>32 >32 >32 Ciprofloxacin ≤0.008–>16 0.03 1.0 Escherichia coli(254) Ertapenem ≤0.008–0.5 ≤0.008 0.016 Imipenem 0.06–2.0 0.12 0.25 Amox-clav 1.0–>32 8.0 32 Ciprofloxacin ≤0.008–>16 0.03 0.06 Klebsiella spp.f(359) Ertapenem ≤0.008–>16 ≤0.008 0.03 Imipenem 0.06–>16 0.25 0.5 Amox-clav 1.0–>32 4.0 16 Ciprofloxacin ≤0.008–>16 0.06 1.0 Pasteurella multocida(22) Ertapenem ≤0.008–0.03 0.016 0.03 Imipenem 0.03–0.5 0.25 0.5 Amox-clav 0.06–0.5 0.25 0.5 Ciprofloxacin ≤0.008–0.06 ≤0.008 0.016 Proteeaeg(284) Ertapenem ≤0.008–4.0 0.016 0.03 Imipenem 0.016–16 4.0 4.0 Amox-clav 0.5–>32 16 >32 Ciprofloxacin ≤0.008–>16 0.06 >16 Pseudomonas aeruginosa(161) Ertapenem 0.12–>16 8.0 >16 Imipenem 0.25–>16 2.0 8.0 Amox-clav 32–>32 >32 >32 Ciprofloxacin 0.03–>16 0.5 >16 Pseudomonas spp.h(29) Ertapenem ≤0.008–>16 8.0 >16 Imipenem 0.12–>16 1.0 >16 Amox-clav 1.0–>32 >32 >32 Ciprofloxacin ≤0.008–>16 0.25 1.0 Salmonellaspp.i(112) Ertapenem ≤0.008–0.06 ≤0.008 ≤0.008 Imipenem 0.12–1.0 0.25 0.5 Amox-clav 1.0–>32 1.0 16 Ciprofloxacin ≤0.008–0.12 0.016 0.03 Serratia marcescens(110) Ertapenem ≤0.008–>16 0.03 0.12 Imipenem 0.12–>16 1.0 2.0 Amox-clav 4.0–>32 >32 >32 Ciprofloxacin ≤0.008–>16 0.25 4.0 Shigella spp.j(37) Ertapenem ≤0.008 ≤0.008 ≤0.008 Imipenem 0.06–0.5 0.25 0.25 Amox-clav 4.0–32 16 32 Ciprofloxacin ≤0.008–0.25 ≤0.008 0.06 Stenotrophomonas maltophilia(54) Ertapenem 1.0–>16 >16 >16 Imipenem 8.0–>16 >16 >16 Amox-clav 4.0–>32 >32 >32 Ciprofloxacin 1.0–>16 8.0 >16 Miscellaneous gram-negative bacteriak(22) Ertapenem ≤0.008–>16 0.03 4.0 Imipenem 0.06–>16 1.0 4.0 Amox-clav 0.12–>32 8.0 32 Ciprofloxacin ≤0.008–>16 0.5 4.0 Haemophilus spp.l(332) Ertapenem ≤0.008–0.5 0.03 0.06 Imipenem ≤0.008–2.0 0.5 1.0 Ampicillin 0.12–>4.0 0.5 >4.0 Ciprofloxacin ≤0.008–16 0.016 0.03 Moraxella catarrhalis(181) Ertapenem ≤0.008–0.25 ≤0.008 0.016 Imipenem ≤0.008–1.0 0.12 0.25 Ampicillin ≤0.03–1.0 0.25 0.5 Ciprofloxacin ≤0.008–0.5 0.016 0.03 Neisseria meningitidis(27) Ertapenem ≤0.008–0.03 ≤0.008 0.016 Imipenem 0.03–1.0 0.25 0.5 Ampicillin 0.12–0.5 0.12 0.25 Ciprofloxacin ≤0.008 ≤0.008 ≤0.008 Corynebacterium spp.m(29) Ertapenem ≤0.008–>16 0.5 >16 Imipenem ≤0.008–>16 1.0 >16 Amox-clav ≤0.03–>32 0.5 >32 Ciprofloxacin 0.5–>16 >16 >16 Enterococcus faecalisn(387) Ertapenem 0.06–>16 8.0 >16 Imipenem 0.03–>16 2.0 16 Amox-clav 0.06–>32 0.5 1.0 Ciprofloxacin 0.25–>16 1.0 >16 Enterococcus faeciumo(140) Ertapenem 0.12–>16 >16 >16 Imipenem 0.25–>16 >16 >16 Amox-clav 0.06–>32 >32 >32 Ciprofloxacin 0.25–>16 >16 >16 Enterococcus spp.p(other) (23) Ertapenem 0.5–>16 8.0 >16 Imipenem 0.03–>16 4.0 >16 Amox-clav 0.12–>32 1.0 32 Ciprofloxacin 0.06–>16 2.0 >16 Staphylococcus aureus Oxacillin susceptible (375) Ertapenem 0.03–>16 0.12 0.25 Imipenem 0.016–>16 0.016 0.03 Amox-clav 0.06–8.0 1.0 1.0 Ciprofloxacin 0.03–>16 0.25 0.5 Oxacillin resistant (172) Ertapenem 0.12–>16 >16 >16 Imipenem 0.03–>16 16 >16 Amox-clav 0.12–>32 >32 >32 Ciprofloxacin 0.12–>16 >16 >16 Staphylococcus spp., coagulase negative Oxacillin susceptible (182) Ertapenem 0.03–4.0 0.12 0.5 Imipenem ≤0.008–1.0 0.016 0.06 Amox-clav ≤0.03–32 0.25 4.0 Ciprofloxacin 0.03–2.0 0.25 0.5 Oxacillin resistant (346) Ertapenem 0.06–>16 8.0 >16 Imipenem ≤0.008–>16 1.0 >16 Amox-clav 0.12–>32 32 >32 Ciprofloxacin 0.06–>16 8.0 >16 Streptococcus agalactiae(206) Ertapenem 0.016–0.25 0.06 0.06 Imipenem ≤0.008–0.06 0.016 0.03 Amox-clav ≤0.03–0.12 0.06 0.12 Ciprofloxacin 0.5–4.0 1.0 1.0 Streptococcus pneumoniae Penicillin susceptible (373) Ertapenem ≤0.008–0.06 0.016 0.03 Imipenem ≤0.008–0.03 ≤0.008 0.016 Amox-clav 0.06–0.25 0.06 0.06 Ciprofloxacin 0.5–16 1.0 2.0 Penicillin intermediate (93) Ertapenem ≤0.008–1.0 0.25 0.5 Imipenem ≤0.008–0.5 0.12 0.25 Amox-clav ≤0.03–2.0 0.5 1.0 Ciprofloxacin 0.5–16 1.0 2.0 Penicillin resistant (110) Ertapenem 0.12–4.0 1.0 2.0 Imipenem 0.12–2.0 0.25 1.0 Amox-clav 0.12–8.0 1.0 8.0 Ciprofloxacin 0.5–8.0 1.0 2.0 Streptococcus pyogenes(238) Ertapenem ≤0.008–0.25 ≤0.008 0.016 Imipenem ≤0.008–0.06 ≤0.008 ≤0.008 Amox-clav ≤0.03–0.12 ≤0.03 ≤0.03 Ciprofloxacin 0.12–2.0 0.5 1.0 Streptococcus spp.q(other) (77) Ertapenem ≤0.008–4.0 0.12 0.5 Imipenem ≤0.008–2.0 0.016 0.12 Amox-clav ≤0.03–8.0 ≤0.03 0.25 Ciprofloxacin 0.016–16 0.5 8.0 Miscellaneous gram-positive bacteriar(38) Ertapenem ≤0.008–>16 0.25 2.0 Imipenem ≤0.008–4.0 0.03 0.12 Amox-clav 0.03–>32 0.12 0.5 Ciprofloxacin 0.03–>16 1.0 4.0 Bacteroides fragilis(56) Ertapenem 0.016–4.0 0.25 1.0 Imipenem ≤0.008–2.0 0.12 0.5 Bacteroides spp.s(64) Ertapenem 0.03–8.0 0.5 2.0 Imipenem 0.03–4.0 0.25 1.0 Clostridium perfringens(21) Ertapenem ≤0.008–0.12 0.06 0.06 Imipenem 0.03–0.5 0.06 0.12 Proprionibacterium acnes(21) Ertapenem 0.03–4.0 0.06 0.25 Imipenem ≤0.008–1.0 ≤0.008 0.03 Miscellaneous anaerobest(48) Ertapenem ≤0.008–4.0 0.12 0.5 Imipenem ≤0.008–2.0 0.06 0.25 ↵a Species (no. of isolates): A. anitratus (12), A. baumannii(59), A. haemolyticus (8), andA. lwoffii (7).
↵b Amox-clav, amoxicillin-clavulanate.
↵c Species (no. of isolates) A. caviae (3), A. hydrophila(11), and Aeromonas spp. NOS (7).
↵d Species (no. of isolates): C. amalonaticus (8), C. brackii(1), C. diversus (18), C. farmeri (3), C. freundii(119), C. koseri (66), andCitrobacter spp. NOS (1).
↵e Species (no. of isolates): E. aerogenes (111), E. agglomerans(9), E. asburiae (1), E. cancerogenus (1), E. cloacae(112), E. intermedius (2),E. sakasaki (1), and Enterobacterspp. NOS (2).
↵f Species (no. of isolates): K. ornitholytica (1), K. oxytoca(103), and K. pneumoniae (255).
↵g Species (no. of isolates): M. morganii (94), P. mirabilis(113), P. vulgaris (25), P. rettgeri (18), and P. stuartii(34).
↵h Species (no. of isolates): P. fluorescens/putida group (22), P. paucimobilis (1), P. stutzeri(2), P. vesiculare (1), andPseudomonas spp. NOS (3).
↵i Species (no. of isolates): S. enterica serovar Tyhi (3) and non-serovar Typhi salmonellae (109).
↵j Species (no. of isolates): S. bovdii (1), S. flexneri (7),S. sonnei (27), and Shigella spp. NOS (2).
↵k Species (no. of isolates): Alcaligenes faecalis (5), Bordetella bronchiseptica(1), Brevundimonas vesicularis(1), Commamonas spp. (1),Flavobacterium breve (1), F. mengosepticum (1), Hafnia alvei(2), Pasteurella spp. NOS (2),Serratia liquefaciens (1), S. rubidaea (1), Shawanella putrefaciens(1), and Yersinia enterocolitica(5).
↵l Species (no. of isolates): H. aegypticus (1), H. aphrophilus(3), H. haemolyticus (4), H. influenzae (233; 86 β-lactamase-positive), H. parahaemolyticus (1), and H. parainfluenzae (30).
↵m Species (no. of isolates): C. afermentans (1), C. amycolatum(1), C. jeikeium (7; resistant to all drugs), C. pseudodiphtheriticum (1),C. striatum (3), C. ureolyticum(3; resistant to all drugs), andCorynebacterium spp. NOS (13).
↵n Includes 10 vancomycin-resistant strains.
↵o Includes 90 vancomycin-resistant strains.
↵p Species (no. of isolates): E. avium (9), E. casseliflavus(3), E. durans (1), E. gallinarum (8), E. raffinosus(1), and Enterococcus spp. NOS (1).
↵q Species (no. of isolates): group C (5), group F (6), group G (21),S. bovis (6), S. milleri(13), S. mitis (2), S. mutans (2), S. salivarius(3), S. sanguis (4), and S. viridans NOS (15).
↵r Species (no. of isolates):Aerococcus spp. NOS (2), A. urinae(4), Bacillus spp. NOS (8),Lactobacillus spp. NOS (10),Micrococcus spp. NOS (13), and L. monocytogenes (1).
↵s Species (no. of isolates): B. fragilis group, NOS (9), B. ovatus(9), B. thetaiotaomicron (19),B. uniformis (11), B. vulgatus(5), and Bacteroides spp. NOS (11).
↵t Species (no. of isolates):Actinomyces spp. (9),Bifidobacterium spp. (2),Clostridium spp. NOS (9), Eubacterium lentum (2), Fusobacterium spp. (6), Peptostreptococcus spp. (10),Prevotella spp. (6),Propionibacterium spp. NOS (3), andVeillonella parvula (1).
