Antimicrobial Agents and Chemotherapy: 45 (7)

July 1, 2001; Volume 45,Issue 7

Guest Commentary

GUEST COMMENTARY
Search for New Drugs for Treatment of Tuberculosis
Tuberculosis Drug Screening Program*

Pharmacology

Pharmacology
Effects of Renal Function on Pharmacokinetics of Recombinant Human Granulocyte Colony-Stimulating Factor in Lung Cancer Patients
Masaaki Fukuda, Mikio Oka, Yoshimasa Ishida, Haruki Kinoshita, Kenji Terashi, Minoru Fukuda, Shigeru Kawabata, Akitoshi Kinoshita, Hiroshi Soda, Shigeru Kohno
Pharmacology
Influence of Human Serum on Antifungal Pharmacodynamics with Candida albicans
George G. Zhanel, David G. Saunders, Daryl J. Hoban, James A. Karlowsky
Pharmacology
Heat Treatment of Amphotericin B Modifies Its Serum Pharmacokinetics, Tissue Distribution, and Renal Toxicity following Administration of a Single Intravenous Dose to Rabbits
Evan H. Kwong, Manisha Ramaswamy, Emily A. Bauer, Scott C. Hartsel, Kishor M. Wasan
Pharmacology
Safety and Pharmacokinetics of Multiple 750-Milligram Doses of Intravenous Levofloxacin in Healthy Volunteers
Andrew T. Chow, Cynthia Fowler, R. Rex Williams, Nancy Morgan, Susan Kaminski, Jaya Natarajan
Pharmacology
Fluoroquinolone Resistance in Anaerobic Bacteria following Exposure to Levofloxacin, Trovafloxacin, and Sparfloxacin in an In Vitro Pharmacodynamic Model
Gigi H. Ross, David H. Wright, Laurie Baeker Hovde, Marnie L. Peterson, John C. Rotschafer
Pharmacology
Pharmacokinetic Evaluation of Oral Levofloxacin in Human Immunodeficiency Virus-Infected Subjects Receiving Concomitant Antiretroviral Therapy
P. Villani, P. Viale, L. Signorini, B. Cadeo, F. Marchetti, A. Villani, C. Fiocchi, M. B. Regazzi, G. Carosi
Pharmacology
Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma
Holly L. Jordan, Arlene S. Pereira, Myron S. Cohen, Angela D. M. Kashuba

Susceptibility

Susceptibility
In Vitro Activities of Linezolid, Meropenem, and Quinupristin-Dalfopristin against Group C and G Streptococci, Including Vancomycin-Tolerant Isolates
Theoklis Zaoutis, Lynn Steele Moore, Kathleen Furness, Joel D. Klein
Susceptibility
Comparison of Hydrogen Peroxide Contact Lens Disinfection Systems and Solutions against Acanthamoeba polyphaga
Reanne Hughes, Simon Kilvington
Susceptibility
Detection of Resistance to Amphotericin B inCandida Isolates by Using Iso-Sensitest Broth
Manuel Cuenca-Estrella, Teresa M. Dı́az-Guerra, Emilia Mellado, Juan L. Rodrı́guez-Tudela
Susceptibility
Desbutyl-Benflumetol, a Novel Antimalarial Compound: In Vitro Activity in Fresh Isolates of Plasmodium falciparumfrom Thailand
Harald Noedl, Thomas Allmendinger, Somsak Prajakwong, Gunther Wernsdorfer, Walther H. Wernsdorfer
Susceptibility
In Vitro Antibiotic Susceptibilities ofBurkholderia mallei (Causative Agent of Glanders) Determined by Broth Microdilution and E-Test
Henry S. Heine, Marilyn J. England, David M. Waag, W. Russell Byrne
Susceptibility
Antimicrobial Activities of Gatifloxacin against Nosocomial Isolates of Stenotrophomonas maltophilia Measured by MIC and Time-Kill Studies
Michael L. Cohn, Ken B. Waites
Susceptibility
Macrolide-Resistant Streptococcus pneumoniae in Canada during 1998–1999: Prevalence ofmef(A) and erm(B) and Susceptibilities to Ketolides
Daryl J. Hoban, Aleksandra K. Wierzbowski, Kim Nichol, George G. Zhanel
Susceptibility
In Vitro Activities of Four Novel Triazoles againstScedosporium spp
A. J. Carrillo, J. Guarro
Susceptibility
Comparative In Vitro Activity of ABT-773, a Novel Antibacterial Ketolide
A. M. Nilius, M. H. Bui, L. Almer, D. Hensey-Rudloff, J. Beyer, Z. Ma, Y. S. Or, R. K. Flamm

Mechanisms of Resistance

Mechanisms of Resistance
Genetic Organization of the Chromosome Region Surrounding mecA in Clinical Staphylococcal Strains: Role of IS431-Mediated mecI Deletion in Expression of Resistance in mecA-Carrying, Low-Level Methicillin- Resistant Staphylococcus haemolyticus
Yuki Katayama, Teruyo Ito, Keiichi Hiramatsu
Mechanisms of Resistance
Pseudomonas aeruginosa Reveals High Intrinsic Resistance to Penem Antibiotics: Penem Resistance Mechanisms and Their Interplay
Kiyomi Okamoto, Naomasa Gotoh, Takeshi Nishino
Mechanisms of Resistance
gyrA Mutations Associated with Quinolone Resistance in Bacteroides fragilis Group Strains
Herin Oh, Nagwa El Amin, Todd Davies, Peter C. Appelbaum, Charlotta Edlund
Mechanisms of Resistance
Inducible Macrolide Resistance inCorynebacterium jeikeium
Adriana E. Rosato, Bonnie S. Lee, Kevin A. Nash
Mechanisms of Resistance
Interaction between DNA Gyrase and Quinolones: Effects of Alanine Mutations at GyrA Subunit Residues Ser⁸³and Asp⁸⁷
Faye M. Barnard, Anthony Maxwell
Mechanisms of Resistance
MexXY-OprM Efflux Pump Is Required for Antagonism of Aminoglycosides by Divalent Cations inPseudomonas aeruginosa
Weimin Mao, Mark S. Warren, Angela Lee, Anita Mistry, Olga Lomovskaya
Mechanisms of Resistance
Identification of Proteus mirabilisMutants with Increased Sensitivity to Antimicrobial Peptides
Andrea J. McCoy, Hongjian Liu, Timothy J. Falla, John S. Gunn
Mechanisms of Resistance
Effect of Abolishment of the Use of Antimicrobial Agents for Growth Promotion on Occurrence of Antimicrobial Resistance in Fecal Enterococci from Food Animals in Denmark
Frank Møller Aarestrup, Anne Mette Seyfarth, Hanne-Dorthe Emborg, Karl Pedersen, René S. Hendriksen, Flemming Bager
Mechanisms of Resistance
All Detectable High-Molecular-Mass Penicillin-Binding Proteins Are Modified in a High-Level β-Lactam-Resistant Clinical Isolate of Streptococcus mitis
Ana Amoroso, Diego Demares, Marta Mollerach, Gabriel Gutkind, Jacques Coyette
Mechanisms of Resistance
DNA Gyrase-Mediated Natural Resistance to Fluoroquinolones in Ehrlichia spp
M. Maurin, C. Abergel, D. Raoult
Mechanisms of Resistance
Discrimination of SHV β-Lactamase Genes by Restriction Site Insertion-PCR
Aroonwadee Chanawong, Fatima Hannachi M'Zali, John Heritage, Aroonlug Lulitanond, Peter Michael Hawkey
Mechanisms of Resistance
Molecular Characterization of a Novel Plasmid-Encoded Cefotaximase (CTX-M-12) Found in Clinical Klebsiella pneumoniae Isolates from Kenya
S. Kariuki, J. E. Corkill, G. Revathi, R. Musoke, C. A. Hart
Mechanisms of Resistance
Resistance to Linezolid: Characterization of Mutations in rRNA and Comparison of Their Occurrences in Vancomycin-Resistant Enterococci
Jason Prystowsky, Farida Siddiqui, John Chosay, Dean L. Shinabarger, John Millichap, Lance R. Peterson, Gary A. Noskin
Mechanisms of Resistance
Novel Mutations in ndh in Isoniazid-Resistant Mycobacterium tuberculosisIsolates
Ann S. G. Lee, Audrey S. M. Teo, Sin-Yew Wong

Clinical Therapeutics

Clinical Therapeutics
Safety and Bactericidal Activity of Rifalazil in Patients with Pulmonary Tuberculosis
Reynaldo Dietze, Luciléia Teixeira, Lia Márcia Canedo Rocha, Moisés Palaci, John L. Johnson, Charles Wells, Lynn Rose, Kathleen Eisenach, Jerrold J. Ellner
Clinical Therapeutics
Prospective Study of Candida Species in Patients at a Comprehensive Cancer Center
Amar Safdar, Vishnu Chaturvedi, Emily W. Cross, Steven Park, Edward M. Bernard, Donald Armstrong, David S. Perlin
Clinical Therapeutics
Clarithromycin Resistance and Eradication ofHelicobacter pylori in Children
N. Kalach, P. H. Benhamou, F. Campeotto, M. Bergeret, C. Dupont, J. Raymond

Experimental Therapeutics

Experimental Therapeutics
Durability of Anti-Infective Effect of Long-Term Silicone Sheath Catheters Impregnated with Antimicrobial Agents
Robert K. Tcholakian, Issam I. Raad
Experimental Therapeutics
Pharmacodynamic Assessment of Gatifloxacin against Streptococcus pneumoniae
Holly M. Mattoes, Maryanne Banevicius, Dadong Li, Christina Turley, Dawei Xuan, Charles H. Nightingale, David P. Nicolau
Experimental Therapeutics
Activity of LY333328 in Experimental Meningitis Caused by a Streptococcus pneumoniae Strain Susceptible to Penicillin
Joachim Gerber, Alexander Smirnov, Andreas Wellmer, Jasmin Ragheb, Juliane Prange, Eckhardt Schütz, Klaus Wettich, Siegfried Kalich, Roland Nau

Mechanisms of Action

Mechanisms of Action: Physiological Effects
Novel Bifunctional Inhibitor of Xylanase and Aspartic Protease: Implications for Inhibition of Fungal Growth
Chandravanu Dash, Absar Ahmad, Devyani Nath, Mala Rao
Mechanisms of Action: Physiological Effects
Inhibition of Fumarate Reductase inLeishmania major and L. donovani by Chalcones
Ming Chen, Lin Zhai, Søren Brøgger Christensen, Thor G. Theander, Arsalan Kharazmi
Mechanisms of Action: Physiological Effects
Antimonial-Mediated DNA Fragmentation inLeishmania infantum Amastigotes
Denis Sereno, Philippe Holzmuller, Isabelle Mangot, Gérard Cuny, Ali Ouaissi, Jean-Loup Lemesre

Antiviral Agents

Antiviral Agents
Effect of Famciclovir on Herpes Simplex Virus Type 1 Corneal Disease and Establishment of Latency in Rabbits
Jeannette M. Loutsch, Bruno Sainz, Mary E. Marquart, Xiaodong Zheng, Prabakaran Kesavan, Shiro Higaki, James M. Hill, Ruth Tal-Singer
Antiviral Agents
Induction of Epstein-Barr Virus Kinases To Sensitize Tumor Cells to Nucleoside Analogues
Stacy M. Moore, Jennifer S. Cannon, Yvette C. Tanhehco, Fayez M. Hamzeh, Richard F. Ambinder
Antiviral Agents
Pharmacodynamic Evaluation of RWJ-270201, a Novel Neuraminidase Inhibitor, in a Lethal Murine Model of Influenza Predicts Efficacy for Once-Daily Dosing
G. L. Drusano, S. L. Preston, D. Smee, K. Bush, K. Bailey, R. W. Sidwell
Antiviral Agents
Biochemical Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to Stavudine
Johan Lennerstrand, David K. Stammers, Brendan A. Larder

Letters

LETTERS TO THE EDITOR
Vancomycin Resistance Plasmid in Enterococcus faecalis That Encodes Sensitivity to a Sex Pheromone Also Produced by Staphylococcus aureus
Sasha A. Showsh, Erika H. De Boever, Don B. Clewell
LETTERS TO THE EDITOR
Inhibitor-Resistant TEM-33 β-Lactamase in a Shigella sonnei Isolate
D. Sirot, C. Chanal, R. Bonnet, C. De Champs, J. Sirot, L. Bret
LETTERS TO THE EDITOR
Update on Rifampin Resistance in the Legionellaceae
Annerose Serr, Barbara F. Koenig, Markus Heep, Kim Nielsen, Jette Marie Bangsborg
LETTERS TO THE EDITOR
Levofloxacin-Resistant Streptococcus pneumoniae: Second Look
Clyde Thornsberry, James A. Karlowsky, Daniel F. Sahm

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Table of Contents

Guest Commentary

Pharmacology

Susceptibility

Mechanisms of Resistance

Clinical Therapeutics

Experimental Therapeutics

Mechanisms of Action

Antiviral Agents

Letters

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