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Pharmacology

Pharmacokinetic Evaluation of Oral Levofloxacin in Human Immunodeficiency Virus-Infected Subjects Receiving Concomitant Antiretroviral Therapy

P. Villani, P. Viale, L. Signorini, B. Cadeo, F. Marchetti, A. Villani, C. Fiocchi, M. B. Regazzi, G. Carosi
P. Villani
Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia,
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P. Viale
Clinic of Infectious Diseases, University of Brescia, Brescia, and
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L. Signorini
Clinic of Infectious Diseases, University of Brescia, Brescia, and
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B. Cadeo
Clinic of Infectious Diseases, University of Brescia, Brescia, and
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F. Marchetti
Healthcare and Clinical Research, Glaxo Wellcome, Verona, Italy
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A. Villani
Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia,
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C. Fiocchi
Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia,
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M. B. Regazzi
Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia,
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G. Carosi
Clinic of Infectious Diseases, University of Brescia, Brescia, and
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DOI: 10.1128/AAC.45.7.2160-2162.2001
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ABSTRACT

The purpose of this study was to evaluate the pharmacokinetics (PK) profile of oral levofloxacin in human immunodeficiency virus-positive patients in steady-state treatment with nelfinavir (NFV) or with efavirenz (EFV) and to determine the effects of levofloxacin on the PK parameters of these two antiretroviral agents. For levofloxacin, plasma samples were obtained at steady state during a 24-h dosing interval. Plasma NFV and EFV concentrations were evaluated before and after 4 days of levofloxacin treatment. Levofloxacin PK do not seem affected by NFV and EFV. There was no significant difference between NFV and EFV plasma levels obtained with and without levofloxacin.

  • Copyright © 2001 American Society for Microbiology
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Pharmacokinetic Evaluation of Oral Levofloxacin in Human Immunodeficiency Virus-Infected Subjects Receiving Concomitant Antiretroviral Therapy
P. Villani, P. Viale, L. Signorini, B. Cadeo, F. Marchetti, A. Villani, C. Fiocchi, M. B. Regazzi, G. Carosi
Antimicrobial Agents and Chemotherapy Jul 2001, 45 (7) 2160-2162; DOI: 10.1128/AAC.45.7.2160-2162.2001

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Pharmacokinetic Evaluation of Oral Levofloxacin in Human Immunodeficiency Virus-Infected Subjects Receiving Concomitant Antiretroviral Therapy
P. Villani, P. Viale, L. Signorini, B. Cadeo, F. Marchetti, A. Villani, C. Fiocchi, M. B. Regazzi, G. Carosi
Antimicrobial Agents and Chemotherapy Jul 2001, 45 (7) 2160-2162; DOI: 10.1128/AAC.45.7.2160-2162.2001
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KEYWORDS

anti-infective agents
HIV infections
levofloxacin
ofloxacin

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