Antimicrobial Agents and Chemotherapy: 46 (1)

January 1, 2002; Volume 46,Issue 1

Minireviews

Minireview
Plasmid-Determined AmpC-Type β-Lactamases
Alain Philippon, Guillaume Arlet, George A. Jacoby

Experimental Therapeutics

Experimental Therapeutics
Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia
Ruta Petraitiene, Vidmantas Petraitis, Andreas H. Groll, Tin Sein, Robert L. Schaufele, Andrea Francesconi, John Bacher, Nilo A. Avila, Thomas J. Walsh
Experimental Therapeutics
Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection
Cyrus J. Bacchi, Louis M. Weiss, Schenella Lane, Benjamin Frydman, Aldonia Valasinas, Venodhar Reddy, Jerry S. Sun, Laurence J. Marton, Imitiaz A. Khan, Magali Moretto, Nigel Yarlett, Murray Wittner
Experimental Therapeutics
Pharmacodynamics of Gatifloxacin against Streptococcus pneumoniae in an In Vitro Pharmacokinetic Model: Impact of Area under the Curve/MIC Ratios on Eradication
Philip D. Lister
Experimental Therapeutics
Single-Dose Intraperitoneal Magainins Improve Survival in a Gram-Negative-Pathogen Septic Shock Rat Model
Oscar Cirioni, Andrea Giacometti, Roberto Ghiselli, Federico Mocchegiani, Anna Fineo, Fiorenza Orlando, Maria Simona Del Prete, Marco Rocchi, Vittorio Saba, Giorgio Scalise
Experimental Therapeutics
Carrier-Mediated Partitioning of Artemisinin into Plasmodium falciparum-Infected Erythrocytes
Nehal Vyas, Bonnie A. Avery, Mitchell A. Avery, Christy M. Wyandt
Experimental Therapeutics
Effects of Flavophospholipol on Resistance in Fecal Escherichia coli and Enterococci of Fattening P
A. E. van den Bogaard, M. Hazen, M. Hoyer, P. Oostenbach, E. E. Stobberingh
Experimental Therapeutics
Efficacy of Short-Course Ceftriaxone Therapy for Borrelia burgdorferi Infection in C3H Mice
Charles Pavia, Mario A. Inchiosa, Gary P. Wormser
Experimental Therapeutics
Optimization of Xanthones for Antimalarial Activity: the 3,6-Bis-ω-Diethylaminoalkoxyxanthone Series
Jane Xu Kelly, Rolf Winter, David H. Peyton, David J. Hinrichs, Michael Riscoe
Experimental Therapeutics
BAL9141, a Novel Extended-Spectrum Cephalosporin Active against Methicillin-Resistant Staphylococcus aureus in Treatment of Experimental Endocarditis
J. M. Entenza, P. Hohl, I. Heinze-Krauss, M. P. Glauser, P. Moreillon
Experimental Therapeutics
Efficacies of BMS 284756 against Penicillin-Sensitive, Penicillin-Resistant, and Quinolone-Resistant Pneumococci in Experimental Meningitis
Philippe Cottagnoud, Fernando Acosta, Marianne Cottagnoud, Marc Pfister, Martin G. Täuber
Experimental Therapeutics
Gentamicin Increases the Efficacy of Vancomycin against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model
Philippe Cottagnoud, Cynthia M. Gerber, Marianne Cottagnoud, Martin G. Täuber
Experimental Therapeutics
Gatifloxacin Efficacy in Treatment of Experimental Methicillin-Sensitive Staphylococcus aureus-Induced Osteomyelitis in Rabbits
Mark E. Shirtliff, Jason H. Calhoun, Jon T. Mader
Experimental Therapeutics
Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters
Chiranjib Pal, Mousumi Raha, Anirban Basu, Keshab Chandra Roy, Anasuya Gupta, Monidipa Ghosh, Niranjan Prasad Sahu, Sukdeb Banerjee, Nirup Bikash Mandal, Santu Bandyopadhyay
Experimental Therapeutics
Pharmacodynamic Interaction of Doxycycline and Artemisinin in Plasmodium falciparum
Ulrike Sponer, Somsak Prajakwong, Gerhard Wiedermann, Herwig Kollaritsch, Gunther Wernsdorfer, Walther H. Wernsdorfer

Mechanisms of Resistance

Mechanisms of Resistance
Conversion of Oxacillin-Resistant Staphylococci from Heterotypic to Homotypic Resistance Expression
J. E. Finan, A. E. Rosato, T. M. Dickinson, D. Ko, Gordon L. Archer
Mechanisms of Resistance
Increased Glycan Chain Length Distribution and Decreased Susceptibility to Moenomycin in a Vancomycin-Resistant Staphylococcus aureus Mutant
Hitoshi Komatsuzawa, Kouji Ohta, Sakuo Yamada, Kerstin Ehlert, Harald Labischinski, Junko Kajimura, Tamaki Fujiwara, Motoyuki Sugai
Mechanisms of Resistance
d-Ala:d-Ala Ligase Gene Flanking the vanC Cluster: Evidence for Presence of Three Ligase Genes in Vancomycin-Resistant Enterococcus gallinarum BM4174
Ole-Herman Ambúr, Peter E. Reynolds, Cesar A. Arias
Mechanisms of Resistance
Diversity of Ribosomal Mutations Conferring Resistance to Macrolides, Clindamycin, Streptogramin, and Telithromycin in Streptococcus pneumoniae
Annie Canu, Brigitte Malbruny, Maëlle Coquemont, Todd A. Davies, Peter C. Appelbaum, Roland Leclercq
Mechanisms of Resistance
Countrywide Spread of CTX-M-3 Extended-Spectrum β-Lactamase-Producing Microorganisms of the Family Enterobacteriaceae in Poland
Anna Baraniak, Janusz Fiett, Agnieszka Sulikowska, Waleria Hryniewicz, Marek Gniadkowski
Mechanisms of Resistance
Interaction of Common Azole Antifungals with P Glycoprotein
Er-jia Wang, Karen Lew, Christopher N. Casciano, Robert P. Clement, William W. Johnson
Mechanisms of Resistance
Pfmdr1 Alleles and Response to Ultralow-Dose Mefloquine Treatment in Gabonese Patients
Denise P. Mawili-Mboumba, Jürgen F. J. Kun, Bertrand Lell, Peter G. Kremsner, Francine Ntoumi
Mechanisms of Resistance
Differential Expression of Methicillin Resistance by Different Biofilm-Negative Staphylococcus epidermidis Transposon Mutant Classes
Dietrich Mack, Axel Sabottke, Sabine Dobinsky, Holger Rohde, Matthias A. Horstkotte, Johannes K.-M. Knobloch
Mechanisms of Resistance
Occurrence of Extended-Spectrum β-Lactamases in Members of the Family Enterobacteriaceae in Italy: Implications for Resistance to β-Lactams and Other Antimicrobial Drugs
T. Spanu, F. Luzzaro, M. Perilli, G. Amicosante, A. Toniolo, G. Fadda, The Italian ESBL Study Group
Mechanisms of Resistance
New erm Gene in Staphylococcus aureus Clinical Isolates
Mayumi Matsuoka, Matsuhisa Inoue, Yoshinori Nakajima, Yoshihiro Endo
Mechanisms of Resistance
Postneurosurgical Meningitis Due to Proteus penneri with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A β-Lactamase HugA and its LysR-Type Regulatory Protein HugR
Nadia Liassine, Stéphanie Madec, Béatrice Ninet, Catherine Metral, Martine Fouchereau-Peron, Roger Labia, Raymond Auckenthaler
Mechanisms of Resistance
Multicenter Study on Spreading of the tet(M) Gene in Tetracycline-Resistant Streptococcus Group G and C Isolates in Argentina
P. E. Jeric, H. Lopardo, P. Vidal, S. Arduino, A. Fernandez, B. E. Orman, D. O. Sordelli, D. Centrón
Mechanisms of Resistance
Nosocomial Outbreak of Carbapenem-Resistant Pseudomonas aeruginosa with a New bla_IMP Allele, bla_IMP-7
Alan Patrick Gibb, Chanwit Tribuddharat, Richard A. Moore, Thomas J. Louie, Wally Krulicki, David M. Livermore, Marie-France I. Palepou, Neil Woodford

Pharmacology

Pharmacology
Pharmacokinetics and Inflammatory Fluid Penetration of Intravenous Daptomycin in Volunteers
R. Wise, T. Gee, J. M. Andrews, B. Dvorchik, G. Marshall
Pharmacology
Pharmacodynamics of Trovafloxacin and Levofloxacin against Bacteroides fragilis in an In Vitro Pharmacodynamic Model
M. L. Peterson, L. B. Hovde, D. H. Wright, G. H. Brown, A. D. Hoang, J. C. Rotschafer
Pharmacology
Single-Dose Pharmacokinetics and Penetration of BMS 284756 into an Inflammatory Exudate
R. Wise, T. Gee, G. Marshall, J. M. Andrews

Susceptibility

Susceptibility
In Vitro Microbicidal Activities of Cecropin Peptides D2A21 and D4E1 and Gel Formulations Containing 0.1 to 2% D2A21 against Chlamydia trachomatis
L. M. Ballweber, J. E. Jaynes, W. E. Stamm, M. F. Lampe
Susceptibility
Antipneumococcal Activity of Ertapenem (MK-0826) Compared to Those of Other Agents
Glenn A. Pankuch, Todd A. Davies, Michael R. Jacobs, Peter C. Appelbaum
Susceptibility
In Vitro Activities of New and Conventional Antifungal Agents against Clinical Scedosporium Isolates
Joseph Meletiadis, Jacques F. G. M. Meis, Johan W. Mouton, Juan Luis Rodriquez-Tudela, J. Peter Donnelly, Paul E. Verweij, the EUROFUNG Network
Susceptibility
Prevalence of Single Mutations in Topoisomerase Type II Genes among Levofloxacin-Susceptible Clinical Strains of Streptococcus pneumoniae Isolated in the United States in 1992 to 1996 and 1999 to 2000
Todd A. Davies, Alan Evangelista, Sharon Pfleger, Karen Bush, Daniel F. Sahm, Raul Goldschmidt
Susceptibility
Bactericidal Activities of BMS-284756, a Novel Des-F(6)-Quinolone, against Staphylococcus aureus Strains with Topoisomerase Mutations
Laura E. Lawrence, MaryBeth Frosco, Brenda Ryan, Susan Chaniewski, Hyekyung Yang, David C. Hooper, John F. Barrett
Susceptibility
In Vitro Antianaerobic Activity of Ertapenem (MK-0826) Compared to Seven Other Compounds
Dianne B. Hoellman, Linda M. Kelly, Kim Credito, Lauren Anthony, Lois M. Ednie, Michael R. Jacobs, Peter C. Appelbaum
Susceptibility
In Vitro Potentiation of Antibiotic Activities by a Catecholate Iron Chelator against Chloroquine-Resistant Plasmodium falciparum
Bruno Pradines, Florence Ramiandrasoa, Jean Marc Rolain, Christophe Rogier, Joel Mosnier, William Daries, Thierry Fusai, Gerhard Kunesch, Jacques Le Bras, Daniel Parzy
Susceptibility
Antimicrobial Activities of BMS-284756 Compared with Those of Fluoroquinolones and β-Lactams against Gram-Positive Clinical Isolates
Matteo Bassetti, Louise M. Dembry, Patricia A. Farrel, Deborah A. Callan, Vincent T. Andriole
Susceptibility
In Vitro Synergy of Caspofungin and Amphotericin B against Aspergillus and Fusarium spp
Sevtap Arikan, Mario Lozano-Chiu, Victor Paetznick, John H. Rex
Susceptibility
Antipneumococcal Activity of BMS 284756 Compared to Those of Six Other Agents
Glenn A. Pankuch, Kensuke Nagai, Todd A. Davies, Michael R. Jacobs, Peter C. Appelbaum

Mechanisms of Action

Mechanisms of Action: Physiological Effects
Mycobacterium smegmatis d-Alanine Racemase Mutants Are Not Dependent on d-Alanine for Growth
Ofelia Chacon, Zhengyu Feng, N. Beth Harris, Nancy E. Cáceres, L. Garry Adams, Raúl G. Barletta
Mechanisms of Action: Physiological Effects
Microcin E492 Is an Unmodified Peptide Related in Structure to Colicin V
Anne-Marie Pons, Nathalie Zorn, David Vignon, François Delalande, Alain Van Dorsselaer, Gilles Cottenceau

Antiviral Agents

Antiviral Agents
Potent Efficacy of Entecavir (BMS-200475) in a Duck Model of Hepatitis B Virus Replication
Patricia L. Marion, Felix H. Salazar, Mark A. Winters, Richard J. Colonno
Antiviral Agents
Prediction of Abacavir Resistance from Genotypic Data: Impact of Zidovudine and Lamivudine Resistance In Vitro and In Vivo
Hauke Walter, Barbara Schmidt, Marianne Werwein, Eva Schwingel, Klaus Korn
Antiviral Agents
Development of Enzymatic Assays for Quantification of Intracellular Lamivudine and Carbovir Triphosphate Levels in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Patients
Stephen Kewn, Patrick G. Hoggard, Sean D. Sales, Kevin Jones, Bridget Maher, Saye H. Khoo, David J. Back

Clinical Therapeutics

Clinical Therapeutics
Antigen Clearance during Treatment of Disseminated Histoplasmosis with Itraconazole versus Fluconazole in Patients with AIDS
L. Joseph Wheat, Patricia Connolly, Nicholas Haddad, Ann Le Monte, Edward Brizendine, Richard Hafner

Errata

Erratum
ATP Synthase Is Necessary for Microcin H47 Antibiotic Action
Mónica Trujillo, Eliana Rodríguez, Magela Laviña

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Table of Contents

Minireviews

Experimental Therapeutics

Mechanisms of Resistance

Pharmacology

Susceptibility

Mechanisms of Action

Antiviral Agents

Clinical Therapeutics

Errata

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