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Experimental Therapeutics

Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia

Ruta Petraitiene, Vidmantas Petraitis, Andreas H. Groll, Tin Sein, Robert L. Schaufele, Andrea Francesconi, John Bacher, Nilo A. Avila, Thomas J. Walsh
Ruta Petraitiene
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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Vidmantas Petraitis
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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Andreas H. Groll
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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Tin Sein
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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Robert L. Schaufele
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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Andrea Francesconi
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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John Bacher
2Surgery Service, Veterinary Resources Program, Office of Research Services
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Nilo A. Avila
3Department of Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
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Thomas J. Walsh
1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
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  • For correspondence: walsht@mail.nih.gov
DOI: 10.1128/AAC.46.1.12-23.2002
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Article Information

DOI 
https://doi.org/10.1128/AAC.46.1.12-23.2002
PubMed 
11751105

Published By 
American Society for Microbiology Journals
History 
  • Received July 23, 2001
  • Returned for modification September 7, 2001
  • Accepted October 14, 2001
  • Published online January 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Ruta Petraitiene1,
  2. Vidmantas Petraitis1,
  3. Andreas H. Groll1,
  4. Tin Sein1,
  5. Robert L. Schaufele1,
  6. Andrea Francesconi1,
  7. John Bacher2,
  8. Nilo A. Avila3 and
  9. Thomas J. Walsh1*
  1. 1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute
  2. 2Surgery Service, Veterinary Resources Program, Office of Research Services
  3. 3Department of Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ↵* Corresponding author. Mailing address: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Rm. 13N240, 10 Center Dr., Bethesda, MD 20892. Phone: (301) 402-0023. Fax: (301) 402-0575. E-mail: walsht{at}mail.nih.gov .
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Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia
Ruta Petraitiene, Vidmantas Petraitis, Andreas H. Groll, Tin Sein, Robert L. Schaufele, Andrea Francesconi, John Bacher, Nilo A. Avila, Thomas J. Walsh
Antimicrobial Agents and Chemotherapy Jan 2002, 46 (1) 12-23; DOI: 10.1128/AAC.46.1.12-23.2002

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Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia
Ruta Petraitiene, Vidmantas Petraitis, Andreas H. Groll, Tin Sein, Robert L. Schaufele, Andrea Francesconi, John Bacher, Nilo A. Avila, Thomas J. Walsh
Antimicrobial Agents and Chemotherapy Jan 2002, 46 (1) 12-23; DOI: 10.1128/AAC.46.1.12-23.2002
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KEYWORDS

Anti-Bacterial Agents
antifungal agents
aspergillosis
Lung Diseases, Fungal
Mannans
peptides
Peptides, Cyclic

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