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Antiviral Agents

Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity

Kirsten L. White, Nicolas A. Margot, Terri Wrin, Christos J. Petropoulos, Michael D. Miller, Lisa K. Naeger
Kirsten L. White
1Gilead Sciences, Foster City, California 94404
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  • For correspondence: kwhite@gilead.com
Nicolas A. Margot
1Gilead Sciences, Foster City, California 94404
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Terri Wrin
2ViroLogic, Inc., South San Francisco, California 94080
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Christos J. Petropoulos
2ViroLogic, Inc., South San Francisco, California 94080
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Michael D. Miller
1Gilead Sciences, Foster City, California 94404
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Lisa K. Naeger
1Gilead Sciences, Foster City, California 94404
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DOI: 10.1128/AAC.46.11.3437-3446.2002
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Article Information

DOI 
https://doi.org/10.1128/AAC.46.11.3437-3446.2002
PubMed 
12384348

Published By 
American Society for Microbiology Journals
History 
  • Received March 8, 2002
  • Returned for modification May 14, 2002
  • Accepted July 22, 2002
  • Published online November 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Kirsten L. White1*,
  2. Nicolas A. Margot1,
  3. Terri Wrin2,
  4. Christos J. Petropoulos2,
  5. Michael D. Miller1 and
  6. Lisa K. Naeger1
  1. 1Gilead Sciences, Foster City, California 94404
  2. 2ViroLogic, Inc., South San Francisco, California 94080
  • ↵* Corresponding author. Mailing address: Gilead Sciences, 333 Lakeside Dr., Foster City, CA 94404. Phone: (650) 522-5162. Fax: (650) 522-5890. E-mail: kwhite{at}gilead.com .

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Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity
Kirsten L. White, Nicolas A. Margot, Terri Wrin, Christos J. Petropoulos, Michael D. Miller, Lisa K. Naeger
Antimicrobial Agents and Chemotherapy Nov 2002, 46 (11) 3437-3446; DOI: 10.1128/AAC.46.11.3437-3446.2002

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Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity
Kirsten L. White, Nicolas A. Margot, Terri Wrin, Christos J. Petropoulos, Michael D. Miller, Lisa K. Naeger
Antimicrobial Agents and Chemotherapy Nov 2002, 46 (11) 3437-3446; DOI: 10.1128/AAC.46.11.3437-3446.2002
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    • ABSTRACT
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KEYWORDS

Anti-HIV Agents
Drug Resistance, Viral
HIV Reverse Transcriptase
HIV-1
mutation
Reverse Transcriptase Inhibitors
Virus Replication

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