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Mechanisms of Action: Physiological Effects

In Vitro Activity of Caspofungin against Candida albicans Biofilms

Stefano P. Bachmann, Kacy VandeWalle, Gordon Ramage, Thomas F. Patterson, Brian L. Wickes, John R. Graybill, José L. López-Ribot
Stefano P. Bachmann
1Department of Medicine, Division of Infectious Diseases
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Kacy VandeWalle
1Department of Medicine, Division of Infectious Diseases
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Gordon Ramage
2Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
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Thomas F. Patterson
1Department of Medicine, Division of Infectious Diseases
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Brian L. Wickes
2Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
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John R. Graybill
1Department of Medicine, Division of Infectious Diseases
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José L. López-Ribot
1Department of Medicine, Division of Infectious Diseases
2Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
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  • For correspondence: RIBOT@UTHSCSA.EDU
DOI: 10.1128/AAC.46.11.3591-3596.2002
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ABSTRACT

Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Caspofungin displayed potent in vitro activity against sessile C. albicans cells within biofilms, with MICs at which 50% of the sessile cells were inhibited well within the drug's therapeutic range. Scanning electron microscopy and confocal scanning laser microscopy were used to visualize the effects of caspofungin on preformed C. albicans biofilms, and the results indicated that caspofungin affected the cellular morphology and the metabolic status of cells within the biofilms. The coating of biomaterials with caspofungin had an inhibitory effect on subsequent biofilm development by C. albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections.

  • Copyright © 2002 American Society for Microbiology
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In Vitro Activity of Caspofungin against Candida albicans Biofilms
Stefano P. Bachmann, Kacy VandeWalle, Gordon Ramage, Thomas F. Patterson, Brian L. Wickes, John R. Graybill, José L. López-Ribot
Antimicrobial Agents and Chemotherapy Nov 2002, 46 (11) 3591-3596; DOI: 10.1128/AAC.46.11.3591-3596.2002

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In Vitro Activity of Caspofungin against Candida albicans Biofilms
Stefano P. Bachmann, Kacy VandeWalle, Gordon Ramage, Thomas F. Patterson, Brian L. Wickes, John R. Graybill, José L. López-Ribot
Antimicrobial Agents and Chemotherapy Nov 2002, 46 (11) 3591-3596; DOI: 10.1128/AAC.46.11.3591-3596.2002
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KEYWORDS

Anti-Bacterial Agents
biofilms
Candida albicans
peptides
Peptides, Cyclic

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