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Mechanisms of Resistance

Genes Involved in Bacitracin Resistance in Streptococcus mutans

Hiromasa Tsuda, Yoshihisa Yamashita, Yukie Shibata, Yoshio Nakano, Toshihiko Koga
Hiromasa Tsuda
1Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582
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Yoshihisa Yamashita
2Department of Oral Health Sciences, Nihon University School of Dentistry, Tokyo 101-8310, Japan
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  • For correspondence: yamashita@dent.nihon-u.ac.jp
Yukie Shibata
1Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582
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Yoshio Nakano
1Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582
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Toshihiko Koga
1Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582
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DOI: 10.1128/AAC.46.12.3756-3764.2002
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ABSTRACT

Streptococcus mutans is resistant to bacitracin, which is a peptide antibiotic produced by certain species of Bacillus. The purpose of this study was to clarify the bacitracin resistance mechanism of S. mutans. We cloned and sequenced two S. mutans loci that are involved in bacitracin resistance. The rgp locus, which is located downstream from rmlD, contains six rgp genes (rgpA to rgpF) that are involved in rhamnose-glucose polysaccharide (RGP) synthesis in S. mutans. The inactivation of RGP synthesis in S. mutans resulted in an approximately fivefold-higher sensitivity to bacitracin relative to that observed for the wild-type strain Xc. The second bacitracin resistance locus comprised four mbr genes (mbrA, mbrB, mbrC, and mbrD) and was located immediately downstream from gtfC, which encodes the water-insoluble glucan-synthesizing enzyme. Although the bacitracin sensitivities of mutants that had defects in flanking genes were similar to that of the parental strain Xc, mutants that were defective in mbrA, mbrB, mbrC, or mbrD were about 100 to 120 times more sensitive to bacitracin than strain Xc. In addition, a mutant that was defective in all of the mbrABCD genes and rgpA was more sensitive to bacitracin than either the RGP or Mbr mutants. We conclude that RGP synthesis is related to bacitracin resistance in S. mutans and that the mbr genes modulate resistance to bacitracin via an unknown mechanism that is independent of RGP synthesis.

  • Copyright © 2002 American Society for Microbiology
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Genes Involved in Bacitracin Resistance in Streptococcus mutans
Hiromasa Tsuda, Yoshihisa Yamashita, Yukie Shibata, Yoshio Nakano, Toshihiko Koga
Antimicrobial Agents and Chemotherapy Dec 2002, 46 (12) 3756-3764; DOI: 10.1128/AAC.46.12.3756-3764.2002

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Genes Involved in Bacitracin Resistance in Streptococcus mutans
Hiromasa Tsuda, Yoshihisa Yamashita, Yukie Shibata, Yoshio Nakano, Toshihiko Koga
Antimicrobial Agents and Chemotherapy Dec 2002, 46 (12) 3756-3764; DOI: 10.1128/AAC.46.12.3756-3764.2002
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KEYWORDS

Anti-Bacterial Agents
bacitracin
Drug Resistance, Bacterial
Streptococcus mutans

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