Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 β-Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins

Andrea M. Hujer; Kristine M. Hujer; Marion S. Helfand; Vernon E. Anderson; Robert A. Bonomo

doi:10.1128/AAC.46.12.3971-3977.2002

DOI: 10.1128/AAC.46.12.3971-3977.2002

Article Information

DOI

https://doi.org/10.1128/AAC.46.12.3971-3977.2002

PubMed

12435703

Published By

American Society for Microbiology Journals

History

Received November 14, 2001
Returned for modification March 16, 2002
Accepted July 26, 2002
Published online December 1, 2002.

American Society for Microbiology

Author Information

Andrea M. Hujer1,
Kristine M. Hujer1,
Marion S. Helfand2,
Vernon E. Anderson3 and
Robert A. Bonomo1,4 *

¹Research Service
⁴Infectious Diseases Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center
²Division of Infectious Diseases, University Hospitals of Cleveland
³Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

↵*Corresponding author. Mailing address: Infectious Disease Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, x4399. Fax: (216) 231-3482. E-mail: robert.bonomo{at}med.va.gov.

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