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Mechanisms of Resistance

Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 β-Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins

Andrea M. Hujer, Kristine M. Hujer, Marion S. Helfand, Vernon E. Anderson, Robert A. Bonomo
Andrea M. Hujer
1Research Service
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Kristine M. Hujer
1Research Service
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Marion S. Helfand
2Division of Infectious Diseases, University Hospitals of Cleveland
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Vernon E. Anderson
3Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
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Robert A. Bonomo
1Research Service
4Infectious Diseases Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center
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  • For correspondence: robert.bonomo@med.va.gov
DOI: 10.1128/AAC.46.12.3971-3977.2002
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Article Information

DOI 
https://doi.org/10.1128/AAC.46.12.3971-3977.2002
PubMed 
12435703

Published By 
American Society for Microbiology Journals
History 
  • Received November 14, 2001
  • Returned for modification March 16, 2002
  • Accepted July 26, 2002
  • Published online December 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Andrea M. Hujer1,
  2. Kristine M. Hujer1,
  3. Marion S. Helfand2,
  4. Vernon E. Anderson3 and
  5. Robert A. Bonomo1,4*
  1. 1Research Service
  2. 4Infectious Diseases Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center
  3. 2Division of Infectious Diseases, University Hospitals of Cleveland
  4. 3Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
  • ↵* Corresponding author. Mailing address: Infectious Disease Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, x4399. Fax: (216) 231-3482. E-mail: robert.bonomo{at}med.va.gov .
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Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 β-Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins
Andrea M. Hujer, Kristine M. Hujer, Marion S. Helfand, Vernon E. Anderson, Robert A. Bonomo
Antimicrobial Agents and Chemotherapy Dec 2002, 46 (12) 3971-3977; DOI: 10.1128/AAC.46.12.3971-3977.2002

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Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 β-Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins
Andrea M. Hujer, Kristine M. Hujer, Marion S. Helfand, Vernon E. Anderson, Robert A. Bonomo
Antimicrobial Agents and Chemotherapy Dec 2002, 46 (12) 3971-3977; DOI: 10.1128/AAC.46.12.3971-3977.2002
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KEYWORDS

Cephalosporin Resistance
mutagenesis
penicillin resistance
beta-lactamases

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