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Susceptibility

Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus

Zhi-Qing Hu, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura
Zhi-Qing Hu
1Department of Microbiology and Immunology, Showa University School of Medicine
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  • For correspondence: zqhu@med.showa-u.ac.jp
Wei-Hua Zhao
1Department of Microbiology and Immunology, Showa University School of Medicine
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Nozomi Asano
1Department of Microbiology and Immunology, Showa University School of Medicine
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Yoshiyuki Yoda
1Department of Microbiology and Immunology, Showa University School of Medicine
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Yukihiko Hara
2Tokyo Food Techno Co. Ltd., Tokyo, Japan
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Tadakatsu Shimamura
1Department of Microbiology and Immunology, Showa University School of Medicine
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DOI: 10.1128/AAC.46.2.558-560.2002
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ABSTRACT

Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 μg/ml, were restored to the susceptible breakpoint (≤4 μg/ml) for 8, 38, 46, and 75% of the MRSA isolates, respectively. Similar results were also observed for combinations of panipenem or meropenem and EGCg. Therefore, the combinations may be worthy of further evaluation in vivo against MRSA infection.

  • Copyright © 2002 American Society for Microbiology
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Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus
Zhi-Qing Hu, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura
Antimicrobial Agents and Chemotherapy Feb 2002, 46 (2) 558-560; DOI: 10.1128/AAC.46.2.558-560.2002

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Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus
Zhi-Qing Hu, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura
Antimicrobial Agents and Chemotherapy Feb 2002, 46 (2) 558-560; DOI: 10.1128/AAC.46.2.558-560.2002
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KEYWORDS

antioxidants
carbapenems
Catechin
methicillin resistance
Staphylococcus aureus

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