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Susceptibility

Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus

Zhi-Qing Hu, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura
Zhi-Qing Hu
1Department of Microbiology and Immunology, Showa University School of Medicine
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  • For correspondence: zqhu@med.showa-u.ac.jp
Wei-Hua Zhao
1Department of Microbiology and Immunology, Showa University School of Medicine
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Nozomi Asano
1Department of Microbiology and Immunology, Showa University School of Medicine
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Yoshiyuki Yoda
1Department of Microbiology and Immunology, Showa University School of Medicine
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Yukihiko Hara
2Tokyo Food Techno Co. Ltd., Tokyo, Japan
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Tadakatsu Shimamura
1Department of Microbiology and Immunology, Showa University School of Medicine
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DOI: 10.1128/AAC.46.2.558-560.2002
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    FIG. 1.

    Synergistic anti-MRSA effects of combinations of IPM and EGCg. (A) Growth inhibition curves. ○, IPM alone; •, IPM plus EGCg at 1.56 μg/ml; ▴, IPM plus EGCg at 3.12 μg/ml; ▾, IPM plus EGCg at 6.25 μg/ml; ⧫, IPM plus EGCg at 12.5 μg/ml; ▪, IPM plus EGCg at 25 μg/ml; OD, optical density. (B) Time-kill curves. ○, no addition; ▵, IPM at 32 μg/ml alone; ▿, EGCg at 25 μg/ml alone; •, IPM at 4 μg/ml plus EGCg at 3.125 μg/ml (1/32 of their MICs); ▴, IPM at 8 μg/ml plus EGCg at 6.25 μg/ml (1/16 of their MICs); ▾, IPM at 16 μg/ml plus EGCg at 12.5 μg/ml (1/8 of their MICs); ▪, IPM at 32 μg/ml plus EGCg at 25 μg/ml (1/4 of their MICs).

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  • TABLE 1.

    Effects of carbapenems in combination with EGCg against 24 MRSA isolates

    CombinationMIC50 (μg/ml)a of combination% of MRSA isolates showing indicated effect:
    SynergisticAdditiveNoneMIC of ≤4 μg/mlb
    EGCg 1.56 μg/ml
        IPM64046540
        PAPM32433634
        MEM64042580
    EGCg 3.125 μg/ml
        IPM324241178
        PAPM162963821
        MEM32386204
    EGCg 6.25 μg/ml
        IPM88317038
        PAPM87517846
        MEM88317025
    EGCg 12.5 μg/ml
        IPM88812046
        PAPM2839867
        MEM88812042
    EGCg 25 μg/ml
        IPM0.25928075
        PAPM0.58812075
        MEM28317071
    • ↵ a MICs at which 50% of the isolates treated with carbapenem alone are inhibited: IPM, 128 μg/ml; PAPM 32 μg/ml; MEM, 64 μg/ml.

    • ↵ b MIC susceptibility breakpoint is ≤4 μg/ml for IPM and MEM, as determined by NCCLS, but is not available for PAPM at present.

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Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus
Zhi-Qing Hu, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura
Antimicrobial Agents and Chemotherapy Feb 2002, 46 (2) 558-560; DOI: 10.1128/AAC.46.2.558-560.2002

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Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus
Zhi-Qing Hu, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura
Antimicrobial Agents and Chemotherapy Feb 2002, 46 (2) 558-560; DOI: 10.1128/AAC.46.2.558-560.2002
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KEYWORDS

antioxidants
carbapenems
Catechin
methicillin resistance
Staphylococcus aureus

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