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Letter to the Editor

Effect of Linezolid in Comparison with That of Vancomycin on Glycocalix Production: In Vitro Study

L. Drago, E. De Vecchi, M. Valli, L. Nicola, M. R. Gismondo
L. Drago
Laboratory of Clinical Microbiology Department of Preclinical Sciences LITA Vialba University of Milan Milan, Italy
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E. De Vecchi
Laboratory of Clinical Microbiology Department of Preclinical Sciences LITA Vialba University of Milan Milan, Italy
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M. Valli
Laboratory of Clinical Microbiology Department of Preclinical Sciences LITA Vialba University of Milan Milan, Italy
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L. Nicola
Laboratory of Clinical Microbiology Department of Preclinical Sciences LITA Vialba University of Milan Milan, Italy
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M. R. Gismondo
Laboratory of Clinical Microbiology Department of Preclinical Sciences LITA Vialba University of Milan Milan, Italy
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  • For correspondence: microbio@mailserver.unimi.it
DOI: 10.1128/AAC.46.2.598-599.2002
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    FIG. 1.

    Bacterial slime of staphylococci before treatment with linezolid and vancomycin (A) or after treatment with 0.5 times the MIC of linezolid (B), 0.25 times the MIC of linezolid (C), or 0.5 times the MIC of vancomycin (D).

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  • TABLE 1.

    Effects of subinhibitory concentrations of linezolid and vancomycin on slime production of S. aureus (n = 8)

    OD340 (mean ± SEM)
    Control0.5× MICa0.25× MICa
    Linezolid0.353 ± 0.0950.063 ± 0.032*0.136 ± 0.056*
    Vancomycin0.353 ± 0.0950.069 ± 0.048*0.191 ± 0.107
    • ↵ a *, P < 0.05 versus control.

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Effect of Linezolid in Comparison with That of Vancomycin on Glycocalix Production: In Vitro Study
L. Drago, E. De Vecchi, M. Valli, L. Nicola, M. R. Gismondo
Antimicrobial Agents and Chemotherapy Feb 2002, 46 (2) 598-599; DOI: 10.1128/AAC.46.2.598-599.2002

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Effect of Linezolid in Comparison with That of Vancomycin on Glycocalix Production: In Vitro Study
L. Drago, E. De Vecchi, M. Valli, L. Nicola, M. R. Gismondo
Antimicrobial Agents and Chemotherapy Feb 2002, 46 (2) 598-599; DOI: 10.1128/AAC.46.2.598-599.2002
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KEYWORDS

Acetamides
Glycocalyx
oxazolidinones
Staphylococcus aureus
vancomycin

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