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Table of Contents

March 1, 2002; Volume 46,Issue 3

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Sublethal Concentrations of Pleurocidin-Derived Antimicrobial Peptides Inhibit Macromolecular Synthesis in Escherichia coli
    Aleksander Patrzykat, Carol L. Friedrich, Lijuan Zhang, Valentina Mendoza, Robert E. W. Hancock
  • Mechanisms of Action: Physiological Effects
    Molecular Evaluation of the Plasma Membrane Proton Pump from Aspergillus fumigatus
    Henriette P. Burghoorn, Patricia Soteropoulos, Padmaja Paderu, Ryota Kashiwazaki, David S. Perlin
  • Mechanisms of Action: Physiological Effects
    1H Nuclear Magnetic Resonance Study of Oxazolidinone Binding to Bacterial Ribosomes
    Casey Chun Zhou, Steven M. Swaney, Dean L. Shinabarger, Brian J. Stockman
  • Mechanisms of Action: Physiological Effects
    Relationship between Chloroquine Toxicity and Iron Acquisition in Saccharomyces cerevisiae
    Lyndal R. Emerson, Martin E. Nau, Rodger K. Martin, Dennis E. Kyle, Maryanne Vahey, Dyann F. Wirth
  • Mechanisms of Action: Physiological Effects
    Neurotoxic Mode of Action of Artemisinin
    Gabriele Schmuck, Elke Roehrdanz, Richard K. Haynes, Regine Kahl
  • Mechanisms of Action: Physiological Effects
    Activities of Polymyxin B and Cecropin A-Melittin Peptide CA(1-8)M(1-18) against a Multiresistant Strain of Acinetobacter baumannii
    José María Saugar, Teresa Alarcón, Susana López-Hernández, Manuel López-Brea, David Andreu, Luis Rivas

Mechanisms of Resistance

  • Mechanisms of Resistance
    Three Cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China
    Aroonwadee Chanawong, Fatima Hannachi M'Zali, John Heritage, Jian-Hui Xiong, Peter Michael Hawkey
  • Mechanisms of Resistance
    Molecular Characterization of a Novel Class 1 Integron Containing blaGES-1 and a Fused Product of aac(3)-Ib/aac(6")-Ib" Gene Cassettes in Pseudomonas aeruginosa
    Véronique Dubois, Laurent Poirel, Caroline Marie, Corinne Arpin, Patrice Nordmann, Claudine Quentin
  • Mechanisms of Resistance
    Mutant TEM β-Lactamase Producing Resistance to Ceftazidime, Ampicillins, and β-Lactamase Inhibitors
    Sergei Vakulenko, Dasantila Golemi
  • Mechanisms of Resistance
    Ribosomal Mutations in Streptococcus pneumoniae Clinical Isolates
    Marja Pihlajamäki, Janne Kataja, Helena Seppälä, John Elliot, Maija Leinonen, Pentti Huovinen, Jari Jalava
  • Mechanisms of Resistance
    Identification and Minisequencing-Based Discrimination of SHV β-Lactamases in Nosocomial Infection-Associated Klebsiella pneumoniae in Brisbane, Australia
    Christopher Howard, Angela van Daal, Gregory Kelly, Jacqueline Schooneveldt, Graeme Nimmo, Philip M. Giffard
  • Mechanisms of Resistance
    Topoisomerase II and IV Quinolone Resistance-Determining Regions in Stenotrophomonas maltophilia Clinical Isolates with Different Levels of Quinolone Susceptibility
    Sylvia Valdezate, Ana Vindel, Aurora Echeita, Fernando Baquero, Rafael Cantó
  • Mechanisms of Resistance
    Evidence of Active Efflux in Resistance to Ciprofloxacin and to Ethidium Bromide by Mycoplasma hominis
    S. Raherison, P. Gonzalez, H. Renaudin, A. Charron, C. Bébéar, C. M. Bébéar
  • Mechanisms of Resistance
    Mutations in ponA, the Gene Encoding Penicillin-Binding Protein 1, and a Novel Locus, penC, Are Required for High-Level Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae
    Patricia A. Ropp, Mei Hu, Melanie Olesky, Robert A. Nicholas
  • Mechanisms of Resistance
    Expression of Efflux Pump Gene pmrA in Fluoroquinolone-Resistant and -Susceptible Clinical Isolates of Streptococcus pneumoniae
    Laura J. V. Piddock, Maggie M. Johnson, S. Simjee, L. Pumbwe
  • Mechanisms of Resistance
    Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae
    Laura J. V. Piddock, M. M. Johnson
  • Mechanisms of Resistance
    Mutator Bacteria as a Risk Factor in Treatment of Infectious Diseases
    Antoine Giraud, Ivan Matic, Miroslav Radman, Michel Fons, François Taddei
  • Mechanisms of Resistance
    Penetration of Rifampin through Staphylococcus epidermidis Biofilms
    Zhilan Zheng, Philip S. Stewart
  • Mechanisms of Resistance
    Characterization of a New Extended-Spectrum β-Lactamase (TEM-87) Isolated in Proteus mirabilis during an Italian Survey
    Mariagrazia Perilli, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, Gianfranco Amicosante

Susceptibility

  • Susceptibility
    Fluoroquinolone Resistance in Streptococcus pneumoniae in United States since 1994-1995
    Angela B. Brueggemann, Stacy L. Coffman, Paul Rhomberg, Holly Huynh, Laurel Almer, Angela Nilius, Robert Flamm, Gary V. Doern
  • Susceptibility
    Antibacterial Properties of Dermaseptin S4 Derivatives with In Vivo Activity
    Shiri Navon-Venezia, Rina Feder, Leonid Gaidukov, Yehuda Carmeli, Amram Mor
  • Susceptibility
    Cytotoxic Activities of Alkylphosphocholines against Clinical Isolates of Acanthamoeba spp
    Julia Walochnik, Michael Duchêne, Karin Seifert, Andreas Obwaller, Thomas Hottkowitz, Gerhard Wiedermann, Hansjörg Eibl, Horst Aspöck
  • Susceptibility
    Comparison of Fractional Inhibitory Concentration Index with Response Surface Modeling for Characterization of In Vitro Interaction of Antifungals against Itraconazole-Susceptible and -Resistant Aspergillus fumigatus Isolates
    D. T. A. Te Dorsthorst, P. E. Verweij, J. F. G. M. Meis, N. C. Punt, J. W. Mouton
  • Susceptibility
    Comparison of In Vitro Activities of ABT-773 and Telithromycin against Macrolide-Susceptible and -Resistant Streptococci and Staphylococci
    Virginia D. Shortridge, Ping Zhong, Zhensheng Cao, Jill M. Beyer, Laurel S. Almer, Nancy C. Ramer, Stella Z. Doktor, Robert K. Flamm
  • Susceptibility
    Antileishmanial Activities of Several Classes of Aromatic Dications
    James J. Brendle, Abram Outlaw, Arvind Kumar, David W. Boykin, Donald A. Patrick, Richard R. Tidwell, Karl A. Werbovetz
  • Susceptibility
    Risk Factors for Piperacillin-Tazobactam-Resistant Pseudomonas aeruginosa among Hospitalized Patients
    Anthony D. Harris, Eli Perencevich, Mary-Claire Roghmann, Glenn Morris, Keith S. Kaye, Judith A. Johnson
  • Susceptibility
    In Vitro Activities of the Des-Fluoro(6) Quinolone BMS-284756 against Aerobic and Anaerobic Pathogens Isolated from Skin and Soft Tissue Animal and Human Bite Wound Infections
    Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, Helen Fernandez
  • Susceptibility
    In Vitro Activities of BAL9141, a Novel Broad-Spectrum Pyrrolidinone Cephalosporin, against Gram-Negative Nonfermenters
    R. Zbinden, V. Pünter, A. von Graevenitz
  • Susceptibility
    High Prevalence of Oxacillin-Resistant Staphylococcus aureus Isolates from Hospitalized Patients in Asia-Pacific and South Africa: Results from SENTRY Antimicrobial Surveillance Program, 1998-1999
    Jan M. Bell, John D. Turnidge
    and SENTRY APAC Participants
  • Susceptibility
    Antitrypanosomal Activities of Tryptanthrins
    John Scovill, Elizabeth Blank, Michael Konnick, Elizabeth Nenortas, Theresa Shapiro
  • Susceptibility
    In Vitro Activities of Tigecycline (GAR-936) against Recently Isolated Clinical Bacteria in Spain
    Carmen Betriu, Iciar Rodríguez-Avial, Blas Ali Sánchez, María Gómez, Juan Álvarez, Juan J. Picazo
    and Spanish Group of Tigecycline
  • Susceptibility
    In Vitro Antibacterial Activities of DQ-113, a Potent Quinolone, against Clinical Isolates
    Mayumi Tanaka, Emi Yamazaki, Megumi Chiba, Kiyomi Yoshihara, Takaaki Akasaka, Makoto Takemura, Kenichi Sato

Antiviral Agents

  • Antiviral Agents
    Interference between D30N and L90M in Selection and Development of Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
    Wataru Sugiura, Zene Matsuda, Yoshiyuki Yokomaku, Kurt Hertogs, Brendan Larder, Tsuyoshi Oishi, Aiko Okano, Teiichirou Shiino, Masashi Tatsumi, Masakazu Matsuda, Hanae Abumi, Noboru Takata, Satoshi Shirahata, Kaneo Yamada, Hiroshi Yoshikura, Yoshiyuki Nagai
  • Antiviral Agents
    Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors
    Gabriel Birkus, Michael J. M. Hitchcock, Tomas Cihlar
  • Antiviral Agents
    Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors
    Nancee L. Oien, Roger J. Brideau, Todd A. Hopkins, Janet L. Wieber, Mary L. Knechtel, John A. Shelly, Robert A. Anstadt, Peter A. Wells, Roger A. Poorman, Audris Huang, Vallerie A. Vaillancourt, Terrance L. Clayton, John A. Tucker, Michael W. Wathen
  • Antiviral Agents
    Emergence of Resistance to Protease Inhibitor Amprenavir in Human Immunodeficiency Virus Type 1-Infected Patients: Selection of Four Alternative Viral Protease Genotypes and Influence of Viral Susceptibility to Coadministered Reverse Transcriptase Nucleoside Inhibitors
    Michael Maguire, Denise Shortino, Astrid Klein, Wendy Harris, Varsha Manohitharajah, Margaret Tisdale, Robert Elston, Jane Yeo, Sharon Randall, Fan Xu, Hayley Parker, Jackie May, Wendy Snowden
  • Antiviral Agents
    Susceptibilities of Herpes Simplex Viruses to Penciclovir and Acyclovir in Eight Cell Lines
    Jeffry J. Leary, Robert Wittrock, Robert T. Sarisky, Adriana Weinberg, Myron J. Levin
  • Antiviral Agents
    RFI-641, a Potent Respiratory Syncytial Virus Inhibitor
    Clayton C. Huntley, William J. Weiss, Anna Gazumyan, Aron Buklan, Boris Feld, William Hu, Thomas R. Jones, Timothy Murphy, Antonia A. Nikitenko, Bryan O'Hara, Gregory Prince, Susan Quartuccio, Yuri E. Raifeld, Philip Wyde, John F. O'Connell
  • Antiviral Agents
    Novel Use of a Guanosine Prodrug Approach To Convert 2',3'-Didehydro-2',3'-Dideoxyguanosine into a Viable Antiviral Agent
    Adrian S. Ray, Zhenjun Yang, Chung K. Chu, Karen S. Anderson
  • Antiviral Agents
    Stable Concentrations of Zidovudine, Stavudine, Lamivudine, Abacavir, and Nevirapine in Serum and Cerebrospinal Fluid during 2 Years of Therapy
    Rieneke M. E. van Praag, Elisabeth C. M. van Weert, Rolf P. G van Heeswijk, Xiao-Jian Zhou, Jean-Pierre Sommadossi, Suzanne Jurriaans, Joep M. A. Lange, Richard M. W. Hoetelmans, Jan M. Prins
  • Antiviral Agents
    Extent of Cross-Resistance between Agents Used To Treat Human Immunodeficiency Virus Type 1 Infection in Clinically Derived Isolates
    P. Richard Harrigan, Brendan A. Larder
  • Antiviral Agents
    Rational Dose Selection for a Nonnucleoside Reverse Transcriptase Inhibitor through Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation
    G. L. Drusano, K. H. P. Moore, J. P. Kleim, W. Prince, A. Bye

Pharmacology

  • Pharmacology
    Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men
    Julie A. Stone, Sherry D. Holland, Peter J. Wickersham, Andrew Sterrett, Michael Schwartz, Cynthia Bonfiglio, Michael Hesney, Gregory A. Winchell, Paul J. Deutsch, Howard Greenberg, Thomas L. Hunt, Scott A. Waldman
  • Pharmacology
    Pharmacokinetic Modeling and Simulations of Interaction of Amprenavir and Ritonavir
    Mark Sale, Brian M. Sadler, Daniel S. Stein
  • Pharmacology
    Doxycycline Induces Expression of P Glycoprotein in MCF-7 Breast Carcinoma Cells
    Katrina L. Mealey, Rola Barhoumi, Robert C. Burghardt, Stephen Safe, Deborah T. Kochevar
  • Pharmacology
    Pharmacokinetics, Excretion, and Mass Balance of Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate in Humans
    Ihor Bekersky, Robert M. Fielding, Dawna E. Dressler, Jean W. Lee, Donald N. Buell, Thomas J. Walsh
  • Pharmacology
    Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate
    Ihor Bekersky, Robert M. Fielding, Dawna E. Dressler, Jean W. Lee, Donald N. Buell, Thomas J. Walsh
  • Pharmacology
    International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma
    Rob E. Aarnoutse, Corrien P. W. G. M. Verweij-van Wissen, Eleonora W. J. van Ewijk-Beneken Kolmer, Eveline W. Wuis, Peter P. Koopmans, Yechiel A. Hekster, David M. Burger
  • Pharmacology
    Intrapulmonary Pharmacokinetics of Telithromycin, a New Ketolide, in Healthy Japanese Volunteers
    Jun-Ichi Kadota, Yuji Ishimatsu, Tetsuji Iwashita, Yuichi Matsubara, Kazunori Tomono, Masao Tateno, Roza Ishihara, Claudette Muller-Serieys, Shigeru Kohno

Clinical Therapeutics

  • Clinical Therapeutics
    Oral Artesunate Dose-Response Relationship in Acute Falciparum Malaria
    Brian J. Angus, Itaporn Thaiaporn, Kenechanh Chanthapadith, Yupin Suputtamongkol, Nicholas J. White

Experimental Therapeutics

  • Experimental Therapeutics
    Quantitative PCR Assay To Evaluate Ampicillin, Ofloxacin, and Doxycycline for Treatment of Experimental Leptospirosis
    Johann Truccolo, Françoise Charavay, Fabrice Merien, Philippe Perolat
  • Experimental Therapeutics
    Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model
    Araceli Parra, Carmen Ponte, Carlos Cenjor, Gloria García-Calvo, María José Giménez, Lorenzo Aguilar, Francisco Soriano
  • Experimental Therapeutics
    Efficacy of Ravuconazole in Treatment of Systemic Murine Histoplasmosis
    K. V. Clemons, M. Martinez, L. Calderon, D. A. Stevens
  • Experimental Therapeutics
    In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii
    Vanessa Yardley, Anis A. Khan, Michael B. Martin, Teri R. Slifer, Fausto G. Araujo, Silvia N. J. Moreno, Roberto Docampo, Simon L. Croft, Eric Oldfield

Letters

  • Letter to the Editor
    First Isolation of a Carbapenem-Hydrolyzing β-Lactamase in Pseudomonas aeruginosa in Spain
    Guillem Prats, Elisenda Miro, Beatriz Mirelis, Laurent Poirel, Samuel Bellais, Patrice Nordmann
  • Letter to the Editor
    In Vitro Activities of Novel Des-Fluoro(6) Quinolone BMS-284756 against Mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus Selected with Different Quinolones
    Franz-Josef Schmitz, Mechthild Boos, Susanne Mayer, Karl Köhrer, Sibylle Scheuring, Ad C. Fluit
  • Letter to the Editor
    Cerebrospinal Fluid Linezolid Concentrations in Postneurosurgical Central Nervous System Infections
    P. Villani, M. B. Regazzi, F. Marubbi, P. Viale, L. Pagani, F. Cristini, B. Cadeo, G. Carosi, R. Bergomi
  • Letter to the Editor
    Importance of Species Selection in Arrythmogenic Models of Q-T Interval Prolongation
    Jeff S. McDermott, Heinz J. Salmen, Bryan F. Cox, Gary A. Gintant

Errata

  • Erratum
    Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations
    Richard G. Nelson, Andre Rosowsky

Author's Correction

  • AUTHOR'S CORRECTION
    Pharmacokinetic Profiles of Nevirapine and Indinavir in Various Fractions of Seminal Plasma
    Rieneke M. E. van Praag, Sjoerd Repping, Jan W. A. de Vries, Joep M. A. Lange, Richard M. W. Hoetelmans, Jan M. Prins
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Antimicrobial Agents and Chemotherapy: 46 (3)

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volume 46, issue 3
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