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Mechanisms of Resistance

Ribosomal Mutations in Streptococcus pneumoniae Clinical Isolates

Marja Pihlajamäki, Janne Kataja, Helena Seppälä, John Elliot, Maija Leinonen, Pentti Huovinen, Jari Jalava
Marja Pihlajamäki
1Antimicrobial Research Laboratory, National Public Health InstituteDepartments of
2 Medicine
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  • For correspondence: mapihla@utu.fi
Janne Kataja
1Antimicrobial Research Laboratory, National Public Health InstituteDepartments of
3 Pediatrics
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Helena Seppälä
1Antimicrobial Research Laboratory, National Public Health InstituteDepartments of
4Ophthalmology, Turku University Central Hospital, Turku
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John Elliot
5Centers for Disease Control and Prevention, Atlanta, Georgia
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Maija Leinonen
6Laboratory for Chlamydia and Bacterial Respiratory Infection, National Public Health Institute, Oulu, Finland
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Pentti Huovinen
1Antimicrobial Research Laboratory, National Public Health InstituteDepartments of
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Jari Jalava
1Antimicrobial Research Laboratory, National Public Health InstituteDepartments of
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DOI: 10.1128/AAC.46.3.654-658.2002
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ABSTRACT

Eleven clinical isolates of Streptococcus pneumoniae, isolated in Finland during 1996 to 2000, had an unusual macrolide resistance phenotype. They were resistant to macrolides and streptogramin B but susceptible, intermediate, or low-level resistant to lincosamides. No acquired macrolide resistance genes were detected from the strains. The isolates were found to have mutations in domain V of the 23S rRNA or ribosomal protein L4. Seven isolates had an A2059C mutation in two to four out of the four alleles encoding the 23S rRNA, two isolates had an A2059G mutation in two alleles, one isolate had a C2611G mutation in all four alleles, and one isolate had a 69GTG71-to-69TPS71 substitution in ribosomal protein L4.

  • Copyright © 2002 American Society for Microbiology
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Ribosomal Mutations in Streptococcus pneumoniae Clinical Isolates
Marja Pihlajamäki, Janne Kataja, Helena Seppälä, John Elliot, Maija Leinonen, Pentti Huovinen, Jari Jalava
Antimicrobial Agents and Chemotherapy Mar 2002, 46 (3) 654-658; DOI: 10.1128/AAC.46.3.654-658.2002

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Ribosomal Mutations in Streptococcus pneumoniae Clinical Isolates
Marja Pihlajamäki, Janne Kataja, Helena Seppälä, John Elliot, Maija Leinonen, Pentti Huovinen, Jari Jalava
Antimicrobial Agents and Chemotherapy Mar 2002, 46 (3) 654-658; DOI: 10.1128/AAC.46.3.654-658.2002
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KEYWORDS

mutation
Pneumococcal Infections
ribosomes
Streptococcus pneumoniae

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