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Mechanisms of Resistance

Characterization of a New Extended-Spectrum β-Lactamase (TEM-87) Isolated in Proteus mirabilis during an Italian Survey

Mariagrazia Perilli, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, Gianfranco Amicosante
Mariagrazia Perilli
1Dipartimento di Scienze e Tecnologie Biomediche
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Bernardetta Segatore
1Dipartimento di Scienze e Tecnologie Biomediche
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Maria Rosaria De Massis
1Dipartimento di Scienze e Tecnologie Biomediche
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Nicola Franceschini
1Dipartimento di Scienze e Tecnologie Biomediche
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Ciro Bianchi
2Dipartimento Medico, Wyeth-Lederle Italia S.p.A., Aprilia, Italy
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Gian Maria Rossolini
4 Università di L'Aquila, L'Aquila, Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Siena
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Gianfranco Amicosante
1Dipartimento di Scienze e Tecnologie Biomediche
3Cattedra di Biochimica Clinica
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  • For correspondence: amicosante@cc.univaq.it
DOI: 10.1128/AAC.46.3.925-928.2002
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ABSTRACT

A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazidime) and aztreonam. Expression of blaTEM-87 in Escherichia coli decreased the host susceptibility to these drugs.

  • Copyright © 2002 American Society for Microbiology
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Characterization of a New Extended-Spectrum β-Lactamase (TEM-87) Isolated in Proteus mirabilis during an Italian Survey
Mariagrazia Perilli, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, Gianfranco Amicosante
Antimicrobial Agents and Chemotherapy Mar 2002, 46 (3) 925-928; DOI: 10.1128/AAC.46.3.925-928.2002

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Characterization of a New Extended-Spectrum β-Lactamase (TEM-87) Isolated in Proteus mirabilis during an Italian Survey
Mariagrazia Perilli, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, Gianfranco Amicosante
Antimicrobial Agents and Chemotherapy Mar 2002, 46 (3) 925-928; DOI: 10.1128/AAC.46.3.925-928.2002
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  • Top
  • Article
    • ABSTRACT
    • Identification of a new natural TEM-derived ESBL, TEM-87, in a P. mirabilis clinical isolate.
    • Purification and properties of TEM-87.
    • Concluding remarks.
    • Nucleotide sequence accession number.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Proteus Infections
Proteus mirabilis
beta-lactamases

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