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Experimental Therapeutics

Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions

David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C. Rotschafer
David H. Wright
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Brent W. Gunderson
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Laurie B. Hovde
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Gigi H. Ross
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Khalid H. Ibrahim
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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John C. Rotschafer
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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  • For correspondence: rotsc001@umn.edu
DOI: 10.1128/AAC.46.5.1561-1563.2002
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ABSTRACT

Six strains of staphylococci were exposed to levofloxacin, moxifloxacin, or trovafloxacin in an in vitro pharmacodynamic model under both aerobic and anaerobic conditions. Each agent demonstrated a rapid 3-log10 kill versus susceptible isolates regardless of condition. Against clinical isolates with reduced susceptibility, regrowth occurred by 24 h and was frequently associated with further increases in MICs.

  • Copyright © 2002 American Society for Microbiology
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Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions
David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C. Rotschafer
Antimicrobial Agents and Chemotherapy May 2002, 46 (5) 1561-1563; DOI: 10.1128/AAC.46.5.1561-1563.2002

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Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions
David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C. Rotschafer
Antimicrobial Agents and Chemotherapy May 2002, 46 (5) 1561-1563; DOI: 10.1128/AAC.46.5.1561-1563.2002
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KEYWORDS

anti-infective agents
Methicillin
methicillin resistance
penicillins
Staphylococcus aureus
Staphylococcus epidermidis

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