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Experimental Therapeutics

Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions

David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C. Rotschafer
David H. Wright
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Brent W. Gunderson
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Laurie B. Hovde
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Gigi H. Ross
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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Khalid H. Ibrahim
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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John C. Rotschafer
University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455
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  • For correspondence: rotsc001@umn.edu
DOI: 10.1128/AAC.46.5.1561-1563.2002
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    FIG. 1.

    Fold increases in MICs of wild-type MRSA and MRSE to moxifloxacin, levofloxacin, and trovafloxacin after exposure to moxifloxacin, levofloxacin, or trovafloxacin. (For example, after MRSA W87 was exposed to levofloxacin for 24 h in an aerobic environment, regrowth was associated with a fourfold increase in the MICs of moxifloxacin and levofloxacin and an eightfold increase in the MIC of trovafloxacin.) No S. epidermidis W126 isolates were recovered at 24 h from in vitro experiments with moxifloxacin.

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    FIG. 2.

    Activities of levofloxacin, moxifloxacin, and trovafloxacin against S. aureus W87 and S. epidermidis W126.

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  • TABLE 1.

    MICs and MBCs for bacteria before antibiotic exposure

    BacteriaPre-antibiotic exposure MIC or MBC (mg/liter)
    LevofloxacinTrovafloxacinMoxifloxacin
    MSSA ATCC 292130.250.030.06
    MRSA ATCC 335920.250.030.06
    MRSA W87822
    MSSE ATCC 122280.250.060.12
    MRSE ATCC 516250.250.030.06
    MRSE W126421
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Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions
David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C. Rotschafer
Antimicrobial Agents and Chemotherapy May 2002, 46 (5) 1561-1563; DOI: 10.1128/AAC.46.5.1561-1563.2002

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Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions
David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C. Rotschafer
Antimicrobial Agents and Chemotherapy May 2002, 46 (5) 1561-1563; DOI: 10.1128/AAC.46.5.1561-1563.2002
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KEYWORDS

anti-infective agents
Methicillin
methicillin resistance
penicillins
Staphylococcus aureus
Staphylococcus epidermidis

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