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Antiviral Agents

A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors

Dimitrios Motakis, Michael A. Parniak
Dimitrios Motakis
Lady Davis Institute for Medical Research and McGill University AIDS Center, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E8, Canada
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Michael A. Parniak
Lady Davis Institute for Medical Research and McGill University AIDS Center, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E8, Canada
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  • For correspondence: parniakm@msx.dept-med.pitt.edu
DOI: 10.1128/AAC.46.6.1851-1856.2002
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Article Information

DOI 
https://doi.org/10.1128/AAC.46.6.1851-1856.2002
PubMed 
12019100

Published By 
American Society for Microbiology Journals
History 
  • Received August 15, 2001
  • Returned for modification November 19, 2001
  • Accepted March 21, 2002
  • Published online June 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Dimitrios Motakis and
  2. Michael A. Parniak*
  1. Lady Davis Institute for Medical Research and McGill University AIDS Center, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E8, Canada
  • ↵* Corresponding author. Present address: Division of Infectious Diseases, University of Pittsburgh, Scaife Hall, Room S818D, 3550 Terrace St., Pittsburgh, PA 15261. Phone: (412) 648-1927. Fax: (412) 340-7502. E-mail: parniakm{at}msx.dept-med.pitt.edu.
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A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors
Dimitrios Motakis, Michael A. Parniak
Antimicrobial Agents and Chemotherapy Jun 2002, 46 (6) 1851-1856; DOI: 10.1128/AAC.46.6.1851-1856.2002

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A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors
Dimitrios Motakis, Michael A. Parniak
Antimicrobial Agents and Chemotherapy Jun 2002, 46 (6) 1851-1856; DOI: 10.1128/AAC.46.6.1851-1856.2002
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KEYWORDS

Anti-HIV Agents
HIV-1
Reverse Transcriptase Inhibitors

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