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Mechanisms of Action: Physiological Effects

Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

Gary Sisson, Avery Goodwin, Ausra Raudonikiene, Nicky J. Hughes, Asish K. Mukhopadhyay, Douglas E. Berg, Paul S. Hoffman
Gary Sisson
1Department of Microbiology and Immunology
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Avery Goodwin
1Department of Microbiology and Immunology
2GlaxoSmithKline, Collegeville, Pennsylvania
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Ausra Raudonikiene
1Department of Microbiology and Immunology
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Nicky J. Hughes
2GlaxoSmithKline, Collegeville, Pennsylvania
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Asish K. Mukhopadhyay
3Department of Molecular Microbiology and Department of Genetics, Washington University Medical School, St. Louis, Missouri
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Douglas E. Berg
3Department of Molecular Microbiology and Department of Genetics, Washington University Medical School, St. Louis, Missouri
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Paul S. Hoffman
1Department of Microbiology and Immunology
2GlaxoSmithKline, Collegeville, Pennsylvania
4Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Dalhousie University, HaliFax, Nova Scotia B3H 4H7
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  • For correspondence: phoffman@tupdean2.med.dal.ca
DOI: 10.1128/AAC.46.7.2116-2123.2002
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Article Information

DOI 
https://doi.org/10.1128/AAC.46.7.2116-2123.2002
PubMed 
12069963

Published By 
American Society for Microbiology Journals
History 
  • Received December 17, 2001
  • Returned for modification February 27, 2002
  • Accepted April 10, 2002
  • Published online July 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Gary Sisson1,
  2. Avery Goodwin1,2,
  3. Ausra Raudonikiene1,
  4. Nicky J. Hughes2,
  5. Asish K. Mukhopadhyay3,
  6. Douglas E. Berg3 and
  7. Paul S. Hoffman1,2,4*
  1. 1Department of Microbiology and Immunology
  2. 4Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Dalhousie University, HaliFax, Nova Scotia B3H 4H7
  3. 2GlaxoSmithKline, Collegeville, Pennsylvania
  4. 3Department of Molecular Microbiology and Department of Genetics, Washington University Medical School, St. Louis, Missouri
  • ↵* Corresponding author. Mailing address: Department of Microbiology and Immunology, Sir Charles Tupper Medical Bldg., Room 7P, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. Phone: (902) 494-3889. Fax: (902) 494-5125. E-mail: phoffman{at}tupdean2.med.dal.ca .

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Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori
Gary Sisson, Avery Goodwin, Ausra Raudonikiene, Nicky J. Hughes, Asish K. Mukhopadhyay, Douglas E. Berg, Paul S. Hoffman
Antimicrobial Agents and Chemotherapy Jul 2002, 46 (7) 2116-2123; DOI: 10.1128/AAC.46.7.2116-2123.2002

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Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori
Gary Sisson, Avery Goodwin, Ausra Raudonikiene, Nicky J. Hughes, Asish K. Mukhopadhyay, Douglas E. Berg, Paul S. Hoffman
Antimicrobial Agents and Chemotherapy Jul 2002, 46 (7) 2116-2123; DOI: 10.1128/AAC.46.7.2116-2123.2002
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KEYWORDS

Helicobacter pylori
Ketone Oxidoreductases
metronidazole
nitrofurans
Nitroreductases
thiazoles

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