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Table of Contents

August 1, 2002; Volume 46,Issue 8

Minireviews

  • Minireview
    Clindamycin as an Antimalarial Drug: Review of Clinical Trials
    Bertrand Lell, Peter G. Kremsner

Experimental Therapeutics

  • Experimental Therapeutics
    Influence of Clarithromycin on Early Atherosclerotic Lesions after Chlamydia pneumoniae Infection in a Rabbit Model
    Ignatius W. Fong, Brian Chiu, Esther Viira, Dan Jang, James B. Mahony
  • Experimental Therapeutics
    Efficacy of Intravenous Liposomal Amphotericin B (AmBisome) against Coccidioidal Meningitis in Rabbits
    Karl V. Clemons, Raymond A. Sobel, Paul L. Williams, Demosthenes Pappagianis, David A. Stevens
  • Experimental Therapeutics
    Efficacy of Caspofungin Alone and in Combination with Voriconazole in a Guinea Pig Model of Invasive Aspergillosis
    William R. Kirkpatrick, Sofia Perea, Brent J. Coco, Thomas F. Patterson
  • Experimental Therapeutics
    Ciprofloxacin in Polyethylene Glycol-Coated Liposomes: Efficacy in Rat Models of Acute or Chronic Pseudomonas aeruginosa Infection
    Irma A. J. M. Bakker-Woudenberg, Marian T. ten Kate, Luke Guo, Peter Working, Johan W. Mouton
  • Experimental Therapeutics
    In Vitro Activities of Quinupristin-Dalfopristin and Cefepime, Alone and in Combination with Various Antimicrobials, against Multidrug-Resistant Staphylococci and Enterococci in an In Vitro Pharmacodynamic Model
    George P. Allen, Raymond Cha, Michael J. Rybak
  • Experimental Therapeutics
    Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models
    Elena Jimenez, Antonio Martínez, El Moukhtar Aliouat, Jesus Caballero, Eduardo Dei-Cas, Domingo Gargallo-Viola
  • Experimental Therapeutics
    Efficacy of Orally Delivered Cochleates Containing Amphotericin B in a Murine Model of Aspergillosis
    G. Delmas, S. Park, Z. W. Chen, F. Tan, R. Kashiwazaki, L. Zarif, D. S. Perlin

Pharmacology

  • Pharmacology
    Comparative Stability Studies of Antipseudomonal β-Lactams for Potential Administration through Portable Elastomeric Pumps (Home Therapy for Cystic Fibrosis Patients) and Motor-Operated Syringes (Intensive Care Units)
    Eric Viaene, Hugues Chanteux, Hélène Servais, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens
  • Pharmacology
    Effects of Gender, AIDS, and Acetylator Status on Intrapulmonary Concentrations of Isoniazid
    John E. Conte, Jeffrey A. Golden, Mari McQuitty, Juliana Kipps, Sheila Duncan, Elaine McKenna, Elisabeth Zurlinden
  • Pharmacology
    Pharmacokinetics and Safety of Voriconazole following Intravenous- to Oral-Dose Escalation Regimens
    L. Purkins, N. Wood, P. Ghahramani, K. Greenhalgh, M. J. Allen, D. Kleinermans
  • Pharmacology
    Transport of an Antifungal Trypsin Inhibitor Isolated from Corn across the Blood-Brain Barrier
    William A. Banks, Michael L. Niehoff, Robert L. Brown, Zhi-Yuan Chen, Thomas E. Cleveland

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Two Diarylurea Electron Transport Inhibitors Reduce Staphylococcus aureus Hemolytic Activity and Protect Cultured Endothelial Cells from Lysis
    R. A. Proctor, S. C. Dalal, B. Kahl, D. Brar, G. Peters, W. W. Nichols
  • Mechanisms of Action: Physiological Effects
    Identification of Small-Molecule Inhibitors of Nucleoside Triphosphate Hydrolase in Toxoplasma gondii
    Takashi Asai, Tsutomu Takeuchi, Jeff Diffenderfer, L. David Sibley
  • Mechanisms of Action: Physiological Effects
    Tetracycline Rapidly Reaches All the Constituent Cells of Uropathogenic Escherichia coli Biofilms
    G. Stone, P. Wood, L. Dixon, M. Keyhan, A. Matin
  • Mechanisms of Action: Physiological Effects
    Sulfadoxine-Pyrimethamine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi
    Karen Hayton, Lisa C. Ranford-Cartwright, David Walliker
  • Mechanisms of Action: Physiological Effects
    Stress-Based Identification and Classification of Antibacterial Agents: Second-Generation Escherichia coli Reporter Strains and Optimization of Detection
    Elyse Shapiro, François Baneyx
  • Mechanisms of Action: Physiological Effects
    Short-Chain Aliphatic Polysulfonates Inhibit the Entry of Plasmodium into Red Blood Cells
    Robert Kisilevsky, Ian Crandall, Walter A. Szarek, Shridhar Bhat, Christopher Tan, Lee Boudreau, Kevin C. Kain
  • Mechanisms of Action: Physiological Effects
    Efficacy of Proton Pump Inhibitor Drugs against Plasmodium falciparum In Vitro and Their Probable Pharmacophores
    Michael A. Riel, Dennis E. Kyle, Apurba K. Bhattacharjee, Wilbur K. Milhous
  • Mechanisms of Action: Physiological Effects
    Salicylate Reduces Susceptibility of Mycobacterium tuberculosis to Multiple Antituberculosis Drugs
    Alain Schaller, Zhonghe Sun, Yongping Yang, Akos Somoskovi, Ying Zhang
  • Mechanisms of Action: Physiological Effects
    Chemiosmotic Mechanism of Antimicrobial Activity of Ag+ in Vibrio cholerae
    Pavel Dibrov, Judith Dzioba, Khoosheh K. Gosink, Claudia C. Häse
  • Mechanisms of Action: Physiological Effects
    Transmission Electron Microscopic Study of Antibiotic Action on Klebsiella pneumoniae Biofilm
    Jeff Zahller, Philip S. Stewart

Mechanisms of Resistance

  • Mechanisms of Resistance
    Tn5406, a New Staphylococcal Transposon Conferring Resistance to Streptogramin A and Related Compounds Including Dalfopristin
    Julien Haroche, Jeanine Allignet, Névine El Solh
  • Mechanisms of Resistance
    Hexapeptide Derivatives of Glycopeptide Antibiotics: Tools for Mechanism of Action Studies
    Norris E. Allen, Deborah L. LeTourneau, Joe N. Hobbs, Richard C. Thompson
  • Mechanisms of Resistance
    Analysis of Penicillin-Binding Protein Genes of Clinical Isolates of Streptococcus pneumoniae with Reduced Susceptibility to Amoxicillin
    Mignon du Plessis, Edouard Bingen, Keith P. Klugman
  • Mechanisms of Resistance
    Class 1 Integron Containing a New Gene Cassette, aadA10, Associated with Tn1404 from R151
    Sally R. Partridge, Christina M. Collis, Ruth M. Hall
  • Mechanisms of Resistance
    Characterization of a Novel Plasmid-Mediated Cephalosporinase (CMY-9) and Its Genetic Environment in an Escherichia coli Clinical Isolate
    Yohei Doi, Naohiro Shibata, Keigo Shibayama, Kazunari Kamachi, Hiroshi Kurokawa, Keiko Yokoyama, Tetsuya Yagi, Yoshichika Arakawa
  • Mechanisms of Resistance
    Mutations in Cytochrome b Resulting in Atovaquone Resistance Are Associated with Loss of Fitness in Plasmodium falciparum
    Jennifer M. Peters, Nanhua Chen, Michelle Gatton, Michael Korsinczky, Elizabeth V. Fowler, Sergio Manzetti, Allan Saul, Qin Cheng
  • Mechanisms of Resistance
    N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase
    Stefan Siemann, Darryl P. Evanoff, Laura Marrone, Anthony J. Clarke, Thammaiah Viswanatha, Gary I. Dmitrienko
  • Mechanisms of Resistance
    Overexpression of Sbe2p, a Golgi Protein, Results in Resistance to Caspofungin in Saccharomyces cerevisiae
    Nir Osherov, Gregory S. May, Nathaniel D. Albert, D. P. Kontoyiannis
  • Mechanisms of Resistance
    Small-Colony Mutants of Staphylococcus aureus Allow Selection of Gyrase-Mediated Resistance to Dual-Target Fluoroquinolones
    Xiao-Su Pan, Penelope J. Hamlyn, Raquel Talens-Visconti, Fabiana L. Alovero, Ruben H. Manzo, L. Mark Fisher
  • Mechanisms of Resistance
    PCR-Based Ordered Genomic Libraries: a New Approach to Drug Target Identification for Streptococcus pneumoniae
    Aimee E. Belanger, Angel Lai, Marcia A. Brackman, Donald J. LeBlanc
  • Mechanisms of Resistance
    Distribution of mef(A) in Gram-Positive Bacteria from Healthy Portuguese Children
    Vicki A. Luna, Marc Heiken, Kathleen Judge, Catherine Ulep, Nicole Van Kirk, Henrique Luis, Mario Bernardo, Jose Leitao, Marilyn C. Roberts
  • Mechanisms of Resistance
    DNA Gyrase and Topoisomerase IV Mutations Associated with Fluoroquinolone Resistance in Proteus mirabilis
    L. M. Weigel, G. J. Anderson, F. C. Tenover
  • Mechanisms of Resistance
    The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen Enterobacter aerogenes
    Elizabeth Pradel, Jean-Marie Pagès
  • Mechanisms of Resistance
    gyrA Polymorphism in Campylobacter jejuni: Detection of gyrA Mutations in 162 C. jejuni Isolates by Single-Strand Conformation Polymorphism and DNA Sequencing
    Antti Hakanen, Jari Jalava, Pirkko Kotilainen, Hannele Jousimies-Somer, Anja Siitonen, Pentti Huovinen
  • Mechanisms of Resistance
    Novel Complex sul1-Type Integron in Escherichia coli Carrying blaCTX-M-9
    Montserrat Sabaté, Ferran Navarro, Elisenda Miró, Susana Campoy, Beatriz Mirelis, Jordi Barbé, Guillem Prats
  • Mechanisms of Resistance
    Incidence, Epidemiology, and Characteristics of Quinolone- Nonsusceptible Streptococcus pneumoniae in Croatia
    Glenn A. Pankuch, Bülent Bozdogan, Kensuke Nagai, Arjana Tambić-Andrašević, Slavko Schoenwald, Tera Tambić, Smilja Kalenić, Sanja Pleško, Nastja K. Tepeš, Zdenka Kotarski, Marina Payerl-Pal, Peter C. Appelbaum
  • Mechanisms of Resistance
    Role of Active Efflux in Association with Target Gene Mutations in Fluoroquinolone Resistance in Clinical Isolates of Vibrio cholerae
    Somesh Baranwal, Keya Dey, T. Ramamurthy, G. Balakrish Nair, Manikuntala Kundu
  • Mechanisms of Resistance
    Rapid Detection of a Molecular Marker for Chloroquine-Resistant Falciparum Malaria
    Rémy Durand, Virginie Huart, Sayeh Jafari, Jacques Le Bras
  • Mechanisms of Resistance
    Extrusion of Penem Antibiotics by Multicomponent Efflux Systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa
    Kiyomi Okamoto, Naomasa Gotoh, Takeshi Nishino
  • Mechanisms of Resistance
    Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae
    Serge Houssaye, Laurent Gutmann, Emmanuelle Varon
  • Mechanisms of Resistance
    Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in Mycobacterium tuberculosis
    Juan-Carlos Palomino, Anandi Martin, Mirtha Camacho, Humberto Guerra, Jean Swings, Françoise Portaels

Antiviral Agents

  • Antiviral Agents
    Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action
    Karen K. Biron, Robert J. Harvey, Stanley C. Chamberlain, Steven S. Good, Albert A. Smith, Michelle G. Davis, Christine L. Talarico, Wayne H. Miller, Robert Ferris, Ronna E. Dornsife, Sylvia C. Stanat, John C. Drach, Leroy B. Townsend, George W. Koszalka
  • Antiviral Agents
    Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication
    George W. Koszalka, Nelson W. Johnson, Steven S. Good, Leslie Boyd, Stanley C. Chamberlain, Leroy B. Townsend, John C. Drach, Karen K. Biron
  • Antiviral Agents
    Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir Exhibit Multiple-Log Enhancement of Antiviral Activity against Cytomegalovirus and Herpesvirus Replication In Vitro
    James R. Beadle, Caroll Hartline, Kathy A. Aldern, Natalie Rodriguez, Emma Harden, Earl R. Kern, Karl Y. Hostetler
  • Antiviral Agents
    Steady-State Pharmacokinetics of Lamivudine in Human Immunodeficiency Virus-Infected Patients with End-Stage Renal Disease Receiving Chronic Dialysis
    Paul R. Bohjanen, Melissa D. Johnson, Lynda A. Szczech, Dannah W. Wray, William P. Petros, Cameron R. Miller, Charles B. Hicks
  • Antiviral Agents
    Inhibition of Cyclin-Dependent Kinase 1 by Purines and Pyrrolo[2,3-d]Pyrimidines Does Not Correlate with Antiviral Activity
    David L. Evers, Julie M. Breitenbach, Katherine Z. Borysko, Leroy B. Townsend, John C. Drach
  • Antiviral Agents
    Efficacies of Entecavir against Lamivudine-Resistant Hepatitis B Virus Replication and Recombinant Polymerases In Vitro
    S. Levine, D. Hernandez, G. Yamanaka, S. Zhang, R. Rose, S. Weinheimer, R. J. Colonno
  • Antiviral Agents
    Novel Nucleoside Analogue MCC-478 (LY582563) Is Effective against Wild-Type or Lamivudine-Resistant Hepatitis B Virus
    Suzane Kioko Ono-Nita, Naoya Kato, Yasushi Shiratori, Flair José Carrilho, Masao Omata
  • Antiviral Agents
    Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor
    A. A. Pilon, J. J. Lum, J. Sanchez-Dardon, B. N. Phenix, R. Douglas, A. D. Badley

Susceptibility

  • Susceptibility
    Methods for Data Mining from Large Multinational Surveillance Studies
    James Poupard, James Brown, Robert Gagnon, Michael J. Stanhope, Chad Stewart
  • Susceptibility
    Comparison of Visual and Spectrophotometric Methods of Broth Microdilution MIC End Point Determination and Evaluation of a Sterol Quantitation Method for In Vitro Susceptibility Testing of Fluconazole and Itraconazole against Trailing and Nontrailing Candida Isolates
    Beth A. Arthington-Skaggs, Wendy Lee-Yang, Meral A. Ciblak, Joao P. Frade, Mary E. Brandt, Rana A. Hajjeh, Lee H. Harrison, Andre N. Sofair, and David W. Warnock
    and for the Candidemia Active Surveillance Group
  • Susceptibility
    Assessment of Azithromycin in Combination with Other Antimalarial Drugs against Plasmodium falciparum In Vitro
    Colin Ohrt, George D. Willingmyre, Patricia Lee, Charles Knirsch, Wilbur Milhous
  • Susceptibility
    Simple Fibroblast-Based Assay for Screening of New Antimicrobial Drugs against Mycobacterium tuberculosis
    Takemasa Takii, Yoshifumi Yamamoto, Taku Chiba, Chiyoji Abe, John T. Belisle, Patrick J. Brennan, Kikuo Onozaki
  • Susceptibility
    Trends in Antimicrobial Resistance among Urinary Tract Infection Isolates of Escherichia coli from Female Outpatients in the United States
    James A. Karlowsky, Laurie J. Kelly, Clyde Thornsberry, Mark E. Jones, Daniel F. Sahm
  • Susceptibility
    Antileishmanial Activity of the Antiulcer Agent Omeprazole
    Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. Mukkada
  • Susceptibility
    In Vitro Activities of Position 2 Substitution-Bearing 6-Nitro- and 6-Amino-Benzothiazoles and Their Corresponding Anthranilic Acid Derivatives against Leishmania infantum and Trichomonas vaginalis
    Florence Delmas, Carole Di Giorgio, Maxime Robin, Nadine Azas, Monique Gasquet, Claire Detang, Muriel Costa, Pierre Timon-David, Jean-Pierre Galy
  • Susceptibility
    In Vitro and In Vivo Activities of Tigecycline (GAR-936), Daptomycin, and Comparative Antimicrobial Agents against Glycopeptide-Intermediate Staphylococcus aureus and Other Resistant Gram-Positive Pathogens
    Peter J. Petersen, Patricia A. Bradford, William J. Weiss, Timothy M. Murphy, P. E. Sum, Steven J. Projan
  • Susceptibility
    Longitudinal Assessment of Antipneumococcal Susceptibility in the United States
    Mark E. Jones, James A. Karlowsky, Renée Blosser-Middleton, Ian A. Critchley, Elena Karginova, Clyde Thornsberry, Daniel F. Sahm
  • Susceptibility
    In Vitro Evaluation of AZD2563, a Novel Oxazolidinone, against 603 Recent Staphylococcal Isolates
    Tamara R. Anderegg, Douglas J. Biedenbach, Ronald N. Jones
  • Susceptibility
    Activities of Six Different Quinolones against Clinical Respiratory Isolates of Streptococcus pneumoniae with Reduced Susceptibility to Ciprofloxacin in Spain
    E. Pérez-Trallero, C. García-Rey, A. M. Martín-Sánchez, L. Aguilar, J. García-de-Lomas, J. Ruiz
    and Spanish Surveillance Group for Respiratory Pathogens (SAUCE Program)
  • Susceptibility
    Two Novel Vaginal Microbicides (Polystyrene Sulfonate and Cellulose Sulfate) Inhibit Gardnerella vaginalis and Anaerobes Commonly Associated with Bacterial Vaginosis
    Jose A. Simoes, Diane M. Citron, Alla Aroutcheva, Robert A. Anderson, Calvin J. Chany, Donald P. Waller, Sebastian Faro, Lourens J. D. Zaneveld
  • Susceptibility
    Biguanide-Atovaquone Synergy against Plasmodium falciparum In Vitro
    K. Jones, S. A. Ward
  • Susceptibility
    In Vitro Susceptibilities of Zygomycetes to Combinations of Antimicrobial Agents
    Eric Dannaoui, Javier Afeltra, Jacques F. G. M. Meis, Paul E. Verweij
    and The Eurofung Network
  • Susceptibility
    Activities of ABT-773 against Microaerophilic and Fastidious Organisms
    Sydney M. Finegold, Denise Molitoris, V. T. Phan, M.-L. Vaisanen, Hannah M. Wexler

Biologic Response Modifiers

  • Biologic Response Modifiers
    Immunomodulatory and Protective Effects of Moxifloxacin against Candida albicans-Induced Bronchopneumonia in Mice Injected with Cyclophosphamide
    Itamar Shalit, Limor Horev-Azaria, Ina Fabian, Hannah Blau, Naam Kariv, Itsak Shechtman, Hannah Alteraz, Yehudith Kletter

Clinical Therapeutics

  • Clinical Therapeutics
    Safety, Pharmacokinetics, and Pharmacodynamics of Cyclodextrin Itraconazole in Pediatric Patients with Oropharyngeal Candidiasis
    Andreas H. Groll, Lauren Wood, Maureen Roden, Diana Mickiene, Christine C. Chiou, Ellen Townley, Luqman Dad, Stephen C. Piscitelli, Thomas J. Walsh
  • Clinical Therapeutics
    Hematologic Effects of Linezolid: Summary of Clinical Experience
    Stanton L. Gerson, Sheldon L. Kaplan, Jon B. Bruss, Vu Le, Felix M. Arellano, Barry Hafkin, David J. Kuter

Chemistry; Biosynthesis

  • Chemistry; Biosynthesis
    Three-Dimensional Quantitative Structure-Activity Relationship and Comparative Molecular Field Analysis of Dipeptide Hydroxamic Acid Helicobacter pylori Urease Inhibitors
    Hetal Mishra, Abby L. Parrill, John S. Williamson
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