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Mechanisms of Resistance

N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase

Stefan Siemann, Darryl P. Evanoff, Laura Marrone, Anthony J. Clarke, Thammaiah Viswanatha, Gary I. Dmitrienko
Stefan Siemann
1Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1
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Darryl P. Evanoff
1Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1
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Laura Marrone
1Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1
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Anthony J. Clarke
2Canadian Bacterial Diseases Network, Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Thammaiah Viswanatha
1Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1
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Gary I. Dmitrienko
1Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1
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  • For correspondence: dmitrien@muskie.uwaterloo.ca
DOI: 10.1128/AAC.46.8.2450-2457.2002
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Article Information

DOI 
https://doi.org/10.1128/AAC.46.8.2450-2457.2002
PubMed 
12121917

Published By 
American Society for Microbiology Journals
History 
  • Received September 28, 2001
  • Returned for modification January 12, 2002
  • Accepted April 9, 2002
  • Published online August 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Stefan Siemann1,
  2. Darryl P. Evanoff1,
  3. Laura Marrone1,
  4. Anthony J. Clarke2,
  5. Thammaiah Viswanatha1 and
  6. Gary I. Dmitrienko1*
  1. 1Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1
  2. 2Canadian Bacterial Diseases Network, Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
  • ↵* Corresponding author. Mailing address: Department of Chemistry, University of Waterloo, 200 University Ave. W., Waterloo, Ontario N2L 3G1, Canada. Phone: (519) 888-4642. Fax: (519) 746-0435. E-mail: dmitrien{at}muskie.uwaterloo.ca .

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N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase
Stefan Siemann, Darryl P. Evanoff, Laura Marrone, Anthony J. Clarke, Thammaiah Viswanatha, Gary I. Dmitrienko
Antimicrobial Agents and Chemotherapy Aug 2002, 46 (8) 2450-2457; DOI: 10.1128/AAC.46.8.2450-2457.2002

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N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase
Stefan Siemann, Darryl P. Evanoff, Laura Marrone, Anthony J. Clarke, Thammaiah Viswanatha, Gary I. Dmitrienko
Antimicrobial Agents and Chemotherapy Aug 2002, 46 (8) 2450-2457; DOI: 10.1128/AAC.46.8.2450-2457.2002
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KEYWORDS

Enzyme Inhibitors
Hydrazones
Sulfonamides
beta-lactamase inhibitors

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