Article Figures & Data
Figures
- FIG. 1.
Cumulative mortality of 12 guinea pigs per treatment group treated with caspofungin (CAS), voriconazole (VRC), caspofungin plus voriconazole, or amphotericin B (AmB). Guinea pigs were challenged on the second day. Controls (□) received no antifungal therapy. Treatment of the guinea pigs with amphotericin B at 1.25 mg/kg/day (▵), caspofungin at 1 mg/kg/day (▪) or 2.5 mg/kg/day (▴), voriconazole at 5 mg/kg/day (⋄), caspofungin at 1 mg/kg/day plus voriconazole at 5 mg/kg/day (*), or caspofungin at 2.5 mg/kg/day plus voriconazole at 5 mg/kg/day (•) was initiated 24 h after challenge and was given daily for 5 days.
Tables
- TABLE 1.
Mean times of survival in temporarily immunosuppressed guinea pigs
Group (dose [mg/kg/day])a Mortality (no. of animals that died/total no. of animals tested) [% of total]) Mean survival time (days)b Mean ± SE Range Control 12/12 (100) 4.5 ± 0.29 3-6 Caspofungin 2.5 6/12 (50)c 6.83 ± 0.37c 5-8 1 4/12 (33)c 7.33 ± 0.31c 5-8 Caspofungin (2.5) + voriconazole (5) 0/12 (0)c 8c 8 Caspofungin (1) + voriconazole (5) 0/12 (0)c 8c 8 Voriconazole (5) 0/12 (0)c 8c 8 Amphotericin B 3/12 (25)c 7.08 ± 0.50c 3-8 - TABLE 2.
Results of semiquantitative cultures of organs from guinea pigs treated with antifungal agents beginning 24 h after challenge and killed 96 h after completion of therapy
Group (dose [mg/kg/day])a Colony count (mean ± SE log10CFU/g of tissue) Liver Lung Kidney Brain Control 3.32 ± 0.20 0.90 ± 0.22 3.11 ± 0.19 3.03 ± 0.23 Caspofungin 2.5 3.19 ± 0.45 0.42 ± 0.13 1.64 ± 0.31b 2.97 ± 0.40 1 1.93 ± 0.48b 0.56 ± 0.23 1.42 ± 0.39b 1.47 ± 0.45 Caspofungin (2.5) + voriconazole (5) 0.32 ± 0.20b 0.11 ± 0.08b 0.34 ± 0.19b 0.13 ± 0.11b Caspofungin (1) + voriconazole (5) 0.08 ± 0.04b 0.05 ± 0.04b 0.13 ± 0.11b 0.19 ± 0.20b Voriconazole (5) 0.35 ± 0.19b 0.30 ± 0.07 0.58 ± 0.19b 0.13 ± 0.09b Amphotericin B 1.22 ± 0.37b 0.38 ± 0.17 0.98 ± 0.32b 0.87 ± 0.44b - TABLE 3.
Results of cultures of organs from temporarily immunosuppressed guinea pigs killed 96 h after completion of therapy
Group (dose [mg/kg/day])a No. of positive cultures/no. of guinea pig organs cultured Liver Lung Kidney Brain Any organ Control 12/12 12/12 12/12 12/12 12/12 Caspofungin 2.5 11/12 10/12 10/12 9/12 12/12 1 12/12 8/12 9/12 7/12 12/12 Caspofungin (2.5) + voriconazole (5) 3/12b 2/12b 4/12b 2/12b 5/12b Caspofungin (1) + voriconazole (5) 3/12b 2/12b 2/12b 1/12b 3/12b Voriconazole 5 6/12 8/12 8/12 3/12b 12/12 Amphotericin B 8/12 6/12 8/12 4/12b 11/12
