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Susceptibility

Antileishmanial Activity of the Antiulcer Agent Omeprazole

Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. Mukkada
Suping Jiang
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0006
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Juliana Meadows
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0006
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Steven A. Anderson
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0006
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Antony J. Mukkada
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0006
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  • For correspondence: mukkada@email.uc.edu
DOI: 10.1128/AAC.46.8.2569-2574.2002
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ABSTRACT

The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania donovani, the causative agent of visceral leishmaniasis. Promastigotes cultured at acidic pH and amastigotes within infected macrophages are reduced 90% or more with 150 μM omeprazole. Antiparasitic action of the drug is due to its inhibition of the P-type K+,H+-ATPase on the surface membrane. This enzyme is important for pH homeostasis and the maintenance of proton motive force across the membrane in Leishmania. The drug is effective only at acidic pH, a condition that mimics the in vivo environment within the phagolysosomal vesicles where the amastigote form of the parasite resides. Omeprazole deserves consideration as an alternative to currently available chemotherapeutics, which have severe toxic side effects.

  • Copyright © 2002 American Society for Microbiology
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Antileishmanial Activity of the Antiulcer Agent Omeprazole
Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. Mukkada
Antimicrobial Agents and Chemotherapy Aug 2002, 46 (8) 2569-2574; DOI: 10.1128/AAC.46.8.2569-2574.2002

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Antileishmanial Activity of the Antiulcer Agent Omeprazole
Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. Mukkada
Antimicrobial Agents and Chemotherapy Aug 2002, 46 (8) 2569-2574; DOI: 10.1128/AAC.46.8.2569-2574.2002
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KEYWORDS

Anti-Ulcer Agents
Antiprotozoal Agents
Leishmania donovani
Omeprazole

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