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Table of Contents

September 1, 2002; Volume 46,Issue 9

Minireviews

  • Minireview
    Resistance to Macrolides and Related Antibiotics in Streptococcus pneumoniae
    Roland Leclercq, Patrice Courvalin

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Importance of the Fourth Alpha-Helix within the CAP Homology Domain of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone Action
    Dirk Strumberg, John L. Nitiss, Jiaowang Dong, Jerrylaine Walker, Marc C. Nicklaus, Kurt W. Kohn, Jonathan G. Heddle, Anthony Maxwell, Siegfried Seeber, Yves Pommier
  • Mechanisms of Action: Physiological Effects
    N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity
    Corinne J. Hackbarth, Dawn Z. Chen, Jason G. Lewis, Kirk Clark, James B. Mangold, Jeffrey A. Cramer, Peter S. Margolis, Wen Wang, Jim Koehn, Charlotte Wu, S. Lopez, George Withers, Helen Gu, Elina Dunn, R. Kulathila, Shi-Hao Pan, Wilma L. Porter, Jeff Jacobs, Joaquim Trias, Dinesh V. Patel, Beat Weidmann, Richard J. White, Zhengyu Yuan
  • Mechanisms of Action: Physiological Effects
    Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid
    Vanja M. Bulatovic, Nancy L. Wengenack, James R. Uhl, Leslie Hall, Glenn D. Roberts, Franklin R. Cockerill, Frank Rusnak
  • Mechanisms of Action: Physiological Effects
    The Antifungal Echinocandin Caspofungin Acetate Kills Growing Cells of Aspergillus fumigatus In Vitro
    J. C. Bowman, P. Scott Hicks, M. B. Kurtz, H. Rosen, D. M. Schmatz, P. A. Liberator, C. M. Douglas
  • Mechanisms of Action: Physiological Effects
    Effect of the Echinocandin Caspofungin on Expression of Candida albicans Secretory Aspartyl Proteinases and Phospholipase In Vitro
    Jean-Sébastien Ripeau, Francine Aumont, Pierre Belhumeur, Luis Ostrosky-Zeichner, John H. Rex, Louis de Repentigny
  • Mechanisms of Action: Physiological Effects
    Development of a Yeast Assay for Rapid Screening of Inhibitors of Human-Derived Pneumocystis carinii Dihydrofolate Reductase
    Liang Ma, Qiuyao Jia, Joseph A. Kovacs

Susceptibility

  • Susceptibility
    Evaluation of Antibiotic Susceptibilities of Three Rickettsial Species Including Rickettsia felis by a Quantitative PCR DNA Assay
    Jean-Marc Rolain, Laetitia Stuhl, Max Maurin, Didier Raoult
  • Susceptibility
    High Incidence of Cefoxitin and Clindamycin Resistance among Anaerobes in Taiwan
    Lee-Jene Teng, Po-Ren Hsueh, Jui-Chang Tsai, Shwu-Jen Liaw, Shen-Wu Ho, Kwen-Tay Luh
  • Susceptibility
    Characterization of Sparsomycin Resistance in Streptomyces sparsogenes
    E. Lázaro, E. Sanz, M. Remacha, J. P. G. Ballesta
  • Susceptibility
    Antistreptococcal Activity of Telithromycin Compared with Seven Other Drugs in Relation to Macrolide Resistance Mechanisms in Russia
    Roman S. Kozlov, Tatiana M. Bogdanovitch, Peter C. Appelbaum, Lois Ednie, Leonid S. Stratchounski, Michael R. Jacobs, Bülent Bozdogan
  • Susceptibility
    In Vitro Interaction of Flucytosine Combined with Amphotericin B or Fluconazole against Thirty-Five Yeast Isolates Determined by both the Fractional Inhibitory Concentration Index and the Response Surface Approach
    D. T. A. Te Dorsthorst, P. E. Verweij, J. Meletiadis, M. Bergervoet, N. C. Punt, J. F. G. M. Meis, J. W. Mouton
  • Susceptibility
    In Vitro Interaction of Caspofungin Acetate with Voriconazole against Clinical Isolates of Aspergillus spp
    Sofia Perea, Gloria Gonzalez, Annette W. Fothergill, William R. Kirkpatrick, Michael G. Rinaldi, Thomas F. Patterson
  • Susceptibility
    Antibiotic Susceptibilities of Parachlamydia acanthamoeba in Amoebae
    M. Maurin, A. Bryskier, D. Raoult
  • Susceptibility
    In Vitro Activities of Garenoxacin (BMS-284756) against 170 Clinical Isolates of Nine Pasteurella Species
    Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, Helen T. Fernandez
  • Susceptibility
    In Vitro and In Vivo Antibacterial Activities of DW286, a New Fluoronaphthyridone Antibiotic
    Hee-Jeong Yun, Yu-Hong Min, Jung-A Lim, Jin-Wook Kang, So-Young Kim, Mi-Jeong Kim, Jae-Hee Jeong, Yun-Jeong Choi, Hyun-Jin Kwon, Yong-Ho Jung, Mi-Ja Shim, Eung-Chil Choi
  • Susceptibility
    Comparative Evaluation of Disk Diffusion with Microdilution Assay in Susceptibility Testing of Caspofungin against Aspergillus and Fusarium Isolates
    Sevtap Arikan, Victor Paetznick, John H. Rex
  • Susceptibility
    Comparative Activities of the Oxazolidinone AZD2563 and Linezolid against Selected Recent North American Isolates of Streptococcus pneumoniae
    Sue E. Baum, Sharon A. Crawford, M. L. McElmeel, Cynthia G. Whitney, James H. Jorgensen

Chemistry; Biosynthesis

  • Chemistry; Biosynthesis
    Heterologous Expression of Epothilone Biosynthetic Genes in Myxococcus xanthus
    Bryan Julien, Sanjay Shah

Mechanisms of Resistance

  • Mechanisms of Resistance
    Different Levels of Genetic Homogeneity in Vancomycin-Resistant and -Susceptible Enterococcus faecium Isolates from Different Human and Animal Sources Analyzed by Amplified-Fragment Length Polymorphism
    Nienke Bruinsma, Rob J. L. Willems, Anthony E. van den Bogaard, Marga van Santen-Verheuvel, Nancy London, Christel Driessen, Ellen E. Stobberingh
  • Mechanisms of Resistance
    The LisRK Signal Transduction System Determines the Sensitivity of Listeria monocytogenes to Nisin and Cephalosporins
    Paul D. Cotter, Caitriona M. Guinane, Colin Hill
  • Mechanisms of Resistance
    Genetic and Biochemical Characterization of CGB-1, an Ambler Class B Carbapenem-Hydrolyzing β-Lactamase from Chryseobacterium gleum
    Samuel Bellais, Thierry Naas, Patrice Nordmann
  • Mechanisms of Resistance
    Frequency of Disinfectant Resistance Genes and Genetic Linkage with β-Lactamase Transposon Tn552 among Clinical Staphylococci
    Maan Singh Sidhu, Even Heir, Truls Leegaard, Karianne Wiger, Askild Holck
  • Mechanisms of Resistance
    Isoniazid-Induced Transient High-Level Resistance in Mycobacterium tuberculosis
    Miguel Viveiros, Isabel Portugal, Rosário Bettencourt, Thomas C. Victor, Annemarie M. Jordaan, Clara Leandro, Diane Ordway, Leonard Amaral
  • Mechanisms of Resistance
    Identification and Analysis of Amino Acid Mutations in Porin IB That Mediate Intermediate-Level Resistance to Penicillin and Tetracycline in Neisseria gonorrhoeae
    Melanie Olesky, Marcia Hobbs, Robert A. Nicholas
  • Mechanisms of Resistance
    Antibiotic Resistance Genes and Salmonella Genomic Island 1 in Salmonella enterica Serovar Typhimurium Isolated in Italy
    Alessandra Carattoli, Emma Filetici, Laura Villa, Anna Maria Dionisi, Antonia Ricci, Ida Luzzi
  • Mechanisms of Resistance
    The Candida dubliniensis CdCDR1 Gene Is Not Essential for Fluconazole Resistance
    Gary Moran, Derek Sullivan, Joachim Morschhäuser, David Coleman
  • Mechanisms of Resistance
    Occurrence of Antibiotic Resistance Gene Cassettes aac(6′)-Ib, dfrA5, dfrA12, and ereA2 in Class I Integrons in Non-O1, Non-O139 Vibrio cholerae Strains in India
    M. Thungapathra, Amita, Kislay K. Sinha, Saumya Ray Chaudhuri, Pallavi Garg, Thandavarayan Ramamurthy, Gopinath Balakrish Nair, Amit Ghosh
  • Mechanisms of Resistance
    In Vitro Selection of Resistance in Haemophilus influenzae by Amoxicillin-Clavulanate, Cefpodoxime, Cefprozil, Azithromycin, and Clarithromycin
    Catherine Clark, Bülent Bozdogan, Mihaela Peric, Bonifacio Dewasse, Michael R. Jacobs, Peter C. Appelbaum
  • Mechanisms of Resistance
    Characterization of a Self-Transferable Plasmid from Salmonella enterica Serotype Typhimurium Clinical Isolates Carrying Two Integron-Borne Gene Cassettes Together with Virulence and Drug Resistance Genes
    Beatriz Guerra, Sara Soto, Reiner Helmuth, M. Carmen Mendoza
  • Mechanisms of Resistance
    16S rRNA Mutation-Mediated Tetracycline Resistance in Helicobacter pylori
    Monique M. Gerrits, Marcel R. de Zoete, Niek L. A. Arents, Ernst J. Kuipers, Johannes G. Kusters
  • Mechanisms of Resistance
    Mutation in 23S rRNA Associated with Macrolide Resistance in Neisseria gonorrhoeae
    Lai-King Ng, Irene Martin, Gary Liu, Louis Bryden
  • Mechanisms of Resistance
    Prospective Survey of β-Lactamases Produced by Ceftazidime- Resistant Pseudomonas aeruginosa Isolated in a French Hospital in 2000
    Christophe De Champs, Laurent Poirel, Richard Bonnet, Danielle Sirot, Catherine Chanal, Jacques Sirot, Patrice Nordmann
  • Mechanisms of Resistance
    Predicting Evolution by In Vitro Evolution Requires Determining Evolutionary Pathways
    Barry G. Hall
  • Mechanisms of Resistance
    β-Lactamases of Kluyvera ascorbata, Probable Progenitors of Some Plasmid-Encoded CTX-M Types
    Christel Humeniuk, Guillaume Arlet, Valerie Gautier, Patrick Grimont, Roger Labia, Alain Philippon
  • Mechanisms of Resistance
    Functional Characterization of Brucella melitensis NorMI, an Efflux Pump Belonging to the Multidrug and Toxic Compound Extrusion Family
    Martine Braibant, Laurence Guilloteau, Michel S. Zygmunt
  • Mechanisms of Resistance
    Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides
    Anne-Laure Prunier, Brigitte Malbruny, Didier Tandé, Bertrand Picard, Roland Leclercq
  • Mechanisms of Resistance
    Incidence of High-Level Evernimicin Resistance in Enterococcus faecium among Food Animals and Humans
    Frank Møller Aarestrup, Paul M. McNicholas

Antiviral Agents

  • Antiviral Agents
    Effect of 5-Iodo-2′-Deoxyuridine on Vaccinia Virus (Orthopoxvirus) Infections in Mice
    Johan Neyts, Erik Verbeken, Erik De Clercq
  • Antiviral Agents
    Penciclovir Susceptibilities of Herpes Simplex Virus Isolates from Patients Using Penciclovir Cream for Treatment of Recurrent Herpes Labialis
    Robert T. Sarisky, Teresa Bacon, Ron Boon, Leslie Locke, Tammy T. Nguyen, Jeffry Leary, Klaus Esser, Robin Saltzman
  • Antiviral Agents
    Samarangenin B from Limonium sinense Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis
    Yuh-Chi Kuo, Lie-Chwen Lin, Wei-Jern Tsai, Cheng-Jen Chou, Szu-Hao Kung, Yen-Hui Ho
  • Antiviral Agents
    Immunomodulatory Effect of Zidovudine (ZDV) on Cytotoxic T Lymphocytes Previously Exposed to ZDV
    Sabine Francke, Charles G. Orosz, Jason Hsu, Lawrence E. Mathes
  • Antiviral Agents
    Antiviral Activities of MCC-478, a Novel and Specific Inhibitor of Hepatitis B Virus
    Naohiro Kamiya, Atsushi Kubota, Yumiko Iwase, Kouichi Sekiya, Masaru Ubasawa, Satoshi Yuasa
  • Antiviral Agents
    Comparative Study of Mechanisms of Herpes Simplex Virus Inactivation by Sodium Lauryl Sulfate and n-Lauroylsarcosine
    Jocelyne Piret, Sylvie Roy, Mylène Gagnon, Sébastien Landry, André Désormeaux, Rabeea F. Omar, Michel G. Bergeron
  • Antiviral Agents
    Application of Real-Time PCR for Determination of Antiviral Drug Susceptibility of Herpes Simplex Virus
    Růžena Stránská, Anton M. van Loon, Merjo Polman, Rob Schuurman
  • Antiviral Agents
    Phase I Dose Escalation Trial Evaluating the Pharmacokinetics, Anti-Human Cytomegalovirus (HCMV) Activity, and Safety of 1263W94 in Human Immunodeficiency Virus-Infected Men with Asymptomatic HCMV Shedding
    Jacob P. Lalezari, Judith A. Aberg, Laurene H. Wang, Mary Beth Wire, Richard Miner, Wendy Snowden, Christine L. Talarico, Shuching Shaw, Mark A. Jacobson, W. Lawrence Drew
  • Antiviral Agents
    Surveillance for Antiviral-Agent-Resistant Herpes Simplex Virus in the General Population with Recurrent Herpes Labialis
    Teresa H. Bacon, Ron J. Boon, Margaret Schultz, Cheryl Hodges-Savola
  • Antiviral Agents
    Phenylpropenamide Derivatives AT-61 and AT-130 Inhibit Replication of Wild-Type and Lamivudine-Resistant Strains of Hepatitis B Virus In Vitro
    William E. Delaney, Ros Edwards, Danni Colledge, Tim Shaw, Phil Furman, George Painter, Stephen Locarnini
  • Antiviral Agents
    Prevalence of Protease and Reverse Transcriptase Drug Resistance Mutations over Time in Drug-Naïve Human Immunodeficiency Virus Type 1-Positive Individuals in Rio de Janeiro, Brazil
    Ana T. Dumans, Marcelo A. Soares, Danuta Pieniazek, Marcia L. Kalish, Veronique De Vroey, Kurt Hertogs, Amilcar Tanuri
  • Antiviral Agents
    Effect of Lamivudine on Transmission of Human T-Cell Lymphotropic Virus Type 1 to Adult Peripheral Blood Mononuclear Cells In Vitro
    Emanuela Balestrieri, Giancarlo Forte, Claudia Matteucci, Antonio Mastino, Beatrice Macchi

Experimental Therapeutics

  • Experimental Therapeutics
    Effects of Neutrophils on Cefazolin Activity and Penicillin-Binding Proteins in Staphylococcus aureus Abscesses
    David M. Bamberger, Betty L. Herndon, Jeffrey Fitch, Aaron Florkowski, Vera Parkhurst
  • Experimental Therapeutics
    Efficacy of Quinupristin-Dalfopristin in Preventing Vascular Graft Infection Due to Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides
    Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Federico Mocchegiani, Alessandra Riva, Maria Simona Del Prete, Vittorio Saba, Giorgio Scalise
  • Experimental Therapeutics
    In Vitro and In Vivo Synergy of Fosmidomycin, a Novel Antimalarial Drug, with Clindamycin
    Jochen Wiesner, Dajana Henschker, David B. Hutchinson, Ewald Beck, Hassan Jomaa
  • Experimental Therapeutics
    Pharmacodynamic Assessment of Ertapenem (MK-0826) against Streptococcuspneumoniae in a Murine Neutropenic Thigh Infection Model
    Dawei Xuan, Maryanne Banevicius, Blair Capitano, Myo-Kyoung Kim, Charles Nightingale, David Nicolau
  • Experimental Therapeutics
    Pharmacokinetic and Pharmacodynamic Profiles of Danofloxacin Administered by Two Dosing Regimens in Calves Infected with Mannheimia (Pasteurella) haemolytica
    Patxi Sarasola, Peter Lees, Fariborz Shojaee AliAbadi, Quintin A. McKellar, William Donachie, Kate A. Marr, Simon J. Sunderland, Tim G. Rowan
  • Experimental Therapeutics
    Efficacies of Quinupristin-Dalfopristin Combined with Vancomycin In Vitro and in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus in Relation to Cross-Resistance to Macrolides, Lincosamides, and Streptogramin B- Type Antibiotics
    Juliette Pavie, Agnès Lefort, Virginie Zarrouk, Françoise Chau, Louis Garry, Roland Leclercq, Bruno Fantin

Clinical Therapeutics

  • Clinical Therapeutics
    Ertapenem versus Ceftriaxone Followed by Appropriate Oral Therapy for Treatment of Complicated Urinary Tract Infections in Adults: Results of a Prospective, Randomized, Double-Blind Multicenter Study
    Kevin M. Tomera, Emmanuel A. Burdmann, Oscar G. Pamo Reyna, Qi Jiang, Wendy M. Wimmer, Gail L. Woods, Richard M. Gesser
    and the Protocol 014 Study Group
  • Clinical Therapeutics
    Consumption of Imipenem Correlates with β-Lactam Resistance in Pseudomonas aeruginosa
    Philipp M. Lepper, Eberhard Grusa, Helga Reichl, Josef Högel, Matthias Trautmann
  • Clinical Therapeutics
    Human Immunodeficiency Virus Type 1 Genotypic and Pharmacokinetic Determinants of the Virological Response to Lopinavir-Ritonavir-Containing Therapy in Protease Inhibitor-Experienced Patients
    Bernard Masquelier, Dominique Breilh, Didier Neau, Sylvie Lawson-Ayayi, Valérie Lavignolle, Jean-Marie Ragnaud, Michel Dupon, Philippe Morlat, F. Dabis, H. Fleury
    and the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine
  • Clinical Therapeutics
    Antibiotic Pharmacodynamics in Surgical Prophylaxis: an Association between Intraoperative Antibiotic Concentrations and Efficacy
    Sheryl A. Zelenitsky, Robert E. Ariano, Godfrey K. M. Harding, Richard E. Silverman

Analytical Procedures

  • Analytical Procedures
    Method for Estimation of Low Outer Membrane Permeability to β-Lactam Antibiotics
    Bernard Lakaye, Alain Dubus, Bernard Joris, Jean-Marie Frère

Pharmacology

  • Pharmacology
    Voriconazole Inhibition of the Metabolism of Tacrolimus in a Liver Transplant Recipient and in Human Liver Microsomes
    Raman Venkataramanan, Shimin Zang, Timothy Gayowski, Nina Singh

Letters

  • Letter to the Editor
    Prevalence of Oxacillin Resistance in Staphylococcus aureus among Inpatients and Outpatients in the United States during 2000
    Mark E. Jones, David C. Mayfield, Clyde Thornsberry, James A. Karlowsky, Daniel F. Sahm, Dan Peterson
  • Letter to the Editor
    Relationship between Antibiotic Resistance in Streptococcus pneumoniae and That in Haemophilus influenzae: Evidence for Common Selective Pressure
    Mark E. Jones, James A. Karlowsky, Renée Blosser-Middleton, Ian Critchley, Clyde Thornsberry, Daniel F. Sahm
  • Letter to the Editor
    gyrA Mutations Associated with Nalidixic Acid-Resistant Salmonellae from Wild Birds
    M. Paloma Reche, José E. García de los Ríos, Pedro A. Jiménez, Ana M. Rojas, Rafael Rotger
  • Letter to the Editor
    Amino Acid Substitutions at Position 69 of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Are Frequent in Zalcitabine-Naive Antiretroviral-Drug-Experienced Patients
    Brigitte Montes, Michel Segondy

Author's Correction

  • AUTHOR'S CORRECTION
    Effects of Gender, AIDS, and Acetylator Status on Intrapulmonary Concentrations of Isoniazid
    John E. Conte, Jeffrey A. Golden, Mari McQuitty, Juliana Kipps, Sheila Duncan, Elaine McKenna, Elisabeth Zurlinden
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Antimicrobial Agents and Chemotherapy: 46 (9)

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