Article Figures & Data
Tables
- TABLE 1.
MIC50 and MIC90 summary for the most common Candida spp. with nine antifungal agentsa
Species (n) MIC (μg/ml) AMB 5FC FLU ITR POS VOR AFG CFG MFG 50% 90% 50% 90% 50% 90% 50% 90% 50% 90% 50% 90% 50% 90% 50% 90% 50% 90% C. albicans (733) 0.06 0.25 0.13 1 0.25 2 0.06 0.5 0.03 0.13 0.03 0.06 0.03 0.03 0.5 0.5 0.03 0.03 C. glabrata (458) 0.13 0.5 0.13 0.13 8 32 1 4 1 2 0.25 1 0.03 0.13 0.5 1 0.03 0.06 C. parapsilosis (391) 0.13 0.5 0.13 0.13 1 2 0.13 0.25 0.03 0.13 0.03 0.06 2 2 2 2 1 2 C. tropicalis (307) 0.13 0.5 0.13 0.5 0.5 16 0.13 1 0.06 1 0.06 2 0.03 0.13 0.5 1 0.03 0.06 C. krusei (50) 0.25 0.5 4 32 32 >64 0.5 1 0.25 0.5 0.5 1 0.06 0.13 1 2 0.13 0.25 C. lusitaniae (20) 0.13 0.5 0.13 0.13 0.5 2 0.06 0.25 0.03 0.13 0.03 0.06 0.06 0.25 1 2 0.06 2 C. dubliniensis (18) 0.03 0.13 0.13 0.13 0.13 0.5 0.03 0.06 0.03 0.06 0.03 0.03 0.03 0.06 0.5 0.5 0.03 0.03 ↵ a Shown are the results for MIC-0 at 24 h for AMB and MIC-2 at 48 h for all other drugs. n, number of isolates.
- TABLE 2.
MICs for infrequent Candida spp.a
Species (n) Median (range) MIC (μg/ml) AMB 5FC FLU ITR POS VOR AFG CFG MFG C. guilliermondii (9) 0.06 (0.03-0.25) 0.13 (0.13-64) 4 (0.25-8) 0.5 (0.03-2) 0.06 (0.03-0.25) 0.06 (0.03-0.13) 1 (0.06-2) 1 (0.5-2) 0.5 (0.06-0.5) C. kefyr (4) 0.5 (0.13-0.5) 0.13 1 (0.13-1) 0.13 (0.03-0.5) 0.06 (0.06-0.25) 0.03 0.06 (0.03-0.5) 0.5 (0.5-1) 0.06 (0.06-0.5) C. lipolytica (2) 1 4 (2-4) 16 (2-16) 2 (0.06-2) 0.25 (0.03-0.25) 0.06 (0.03-0.06) 1 (0.03-1) 2 (0.5-2) 0.5 (0.13-0.5) C. rugosa (7) 0.13 (0.03-0.5) 0.25 (0.13-0.25) 4 (1-16) 0.06 (0.03-1) 0.03 (0.03-1) 0.03 (0.03-0.25) 0.03 (0.03-4) 2 (1-2) 0.06 (0.03->64) C. sphaerica (1) 0.13 0.13 4 0.13 0.13 0.03 0.13 2 0.25 ↵ a Shown are the results for MIC-0 at 24 h for AMB and MIC-2 at 48 h for all other drugs. n, no. of isolates.
- TABLE 3.
Resistance rates for antifungals with published interpretive breakpointsa
Species (n) Frequency (%) of resistance to: AMB 5FC FLU ITR C. albicans (733) 0 3 5 8 C. glabrata (458) 0.8 0.2 8 51 C. parapsilosis (391) 2.5 2 2 4 C. tropicalis (307) 0.3 6 8 12 C. krusei (50) 2 12 34 20 C. lusitaniae (20) 0 0 0 0 C. dubliniensis (18) 0 0 0 0 Overall 0.8 3 6 18 ↵ a Resistance is defined as the following MICs (in micrograms per milliliter): AMB, >1; 5FC, ≥32; FLU, ≥64; and ITR, ≥1. n, no. of isolates.
- TABLE 4.
Cross-distribution of azole congener MICsa
Drug MIC (μg/ml) No. of isolates with MIC combination VOR MIC (μg/ml) POS MIC (μg/ml) 0.03 0.06 0.13 0.25 0.5 1 2 4 8 16 >16 0.03 0.06 0.13 0.25 0.5 1 2 4 8 16 >16 FLU 0.13 191 5 1 1 1 1 0.25 368 15 3 2 2 2 1 5 0.5 293 53 9 3 3 2 1 1 1 1 3 1 182 46 26 5 3 2 3 1 4 2 60 27 20 5 3 1 1 2 3 4 14 30 43 25 4 4 1 1 1 2 8 6 15 55 66 35 5 4 1 16 2 3 8 25 48 35 2 1 32 3 2 4 21 15 27 5 1 1 2 64 5 4 13 3 9 2 1 >64 14 2 2 1 3 9 7 16 11 2 17 ITR 0.03 374 17 1 1 1 1 0.06 296 160 29 5 3 2 1 2 1 1 0.13 116 109 27 10 6 1 0.25 24 76 52 31 17 6 1 0.5 8 23 17 59 109 42 8 3 1 2 1 3 2 5 7 50 80 23 3 2 7 2 3 4 10 23 28 4 2 4 4 1 2 1 1 2 20 17 2 1 3 8 1 2 2 2 1 16 1 2 2 2 1 >16 4 1 2 5 6 4 12 ↵ a Distribution of VOR MICs by FLU MICs (r2 = 0.48) and POS MICs by ITR MICs (r2 = 0.65). All MICs are MIC-2 at 48 h.
- TABLE 5.
MIC variations by differences in test medium and solvent when compared to RPMI and standard solvent for 344 Candida spp. isolatesa
Drug % of isolates for which result of MIC comparison applies in: RPMI-2% GLU RPMI-2% GLU + PEG solvent RPMI + PEG solvent Identical Up to 2 dilutions higher Up to 2 dilutions lower Identical Up to 2 dilutions higher Up to 2 dilutions lower Identical Up to 2 dilutions higher Up to 2 dilutions lower AFG 48 50 2 CFG 51 30 18 FLU 54 1 42 5FC 83 1 16 ITR 28 57 14 52 0 43 60 6 34 POS 68 14 14 66 1 26 69 2 27 VOR 81 3 14 69 1 27 73 1 25 ↵ a Data are shown for MIC-2 at 48 h. GLU, glucose.
- TABLE 6.
Frequency of the trailing phenomenon by drug and Candida spp.a
Species Frequency (%) of trailing with: 5FC FLU ITR POS VOR AFG CFG MFG C. albicans 9 12 13 6 6 1 3 2 C. glabrata 1 14 29 30 32 2 2 2 C. krusei 18 14 25 20 14 2 6 4 C. parapsilosis 3 7 11 4 2 16 12 11 C. tropicalis 4 22 19 17 22 1 3 2 ↵ a Trailing growth was defined as an eightfold increase of the MIC-2 between 24 and 48 h.
