DOI: 10.1128/AAC.47.10.3352-3356.2003
Article Figures & Data
Tables
- TABLE 1.
MICs of PGE-9509924, levofloxacin, and ciprofloxacin for the various strains
Strain MIC (mg/liter) PGE-9509924 Levofloxacin by BioScreen Ciprofloxacin by BioScreen Macrodilution BioScreen S. pneumoniae ATCC 6306 0.03 0.03 1 0.5 S. pneumoniae R 2151 0.03 0.06 1 0.5 S. aureus ATCC 29213 0.03 0.03 0.25 0.25 S. aureus Col. 1841 0.03 0.03 0.25 0.25 S. aureus CCUG 35601 0.03 0.03 0.5 0.5 E. coli ATCC 25922 0.125 0.06 0.03 0.016 K. pneumoniae ATCC 13883 0.5 0.125 0.06 0.03 P. aeruginosa ATCC 27853 2 2 2 0.5 - TABLE 2.
PAEs of PGE-9509924, levofloxacin, and ciprofloxacin
Strain PAEa (h) PGE-9509924 Levofloxacin by BioScreen Ciprofloxacin by BioScreen Viable counts BioScreen S. pneumoniae ATCC 6306 4.3 (4.0-4.4) 6.8 (3.2-10.4) 2.2 (2.0-2.3) 1.2 (0.9-1.4) S. pneumoniae R2151 4.0 (3.6-4.3) 6.9 (6.6-7.2) 1.7 (1.3-2.0) 0.4 (0.3-0.4) S. aureus ATCC 29213 2.3 (1.8-3.0) 2.6 (2.0-3.2) 2.2 (2.0-2.3) 0.6 (0.3-0.8) S. aureus Col. 1841 6.7 (4.6-9.0) 1.1 (0.3-1.9) 1.3 (1.2-1.3) 2.1 (1.1-3.1) S. aureus CCUG 35601 3.8 (2.3-6.0) 0.3 (0-0.6) 1.2 (0.6-1.8) 2.3 (1.4-3.1) E. coli ATCC 25922 3.7 (2.8-4.5) 2.3 (2.1-2.4) 2.8 (2.4-3.2) 2.5 (2.4-2.6) K. pneumoniae ATCC 13883 2.2 (2-2.3) 0.9 (0.9-0.9) 0.7 (0.5-0.9) 0.7 (0.4-0.9) P. aeruginosa ATCC 27853 0.9 (0.5-1.4) 0.1 (−0.9-1.0) 0.1 (−0.2-0.4) 0.6 (0.5-0.6) ↵ a Values are means of two experiments, with ranges in parentheses.
- TABLE 3.
PA SMEs of PGE-9509924, levofloxacin, and ciprofloxacin
Strain PA SMEa (h) at indicated multiple of the MIC PGE-9509924 Levofloxacin Ciprofloxacin 0.1 0.2 0.3 0.1 0.2 0.3 0.1 0.2 0.3 S. pneumoniae ATCC 6306 11.4 (4.7-18.1) 12.4 (6.6-18.1) 15.9 (13.7-18.1) 3.0 (2.9-3.0) 4.4 (3.3-5.4) 19.6 (19.2-20) 1.9 (1.7-2.1) 4.0 (4.0-4.0) 7.3 (7.1-7.5) S. pneumoniae R 2151 8.7 (8.1-9.3) 11.5 (11-12) 13.2 (12.14.4) 3.2 (3.0-3.3) 7.8 (5.4-10.1) 13.2 (10.9-15.4) 1.3 (1.0-1.5) 3.4 (2.4-4.4) 7.0 (4.6-9.4) S. aureus ATCC 29213 4.5 (4.1-4.9) 14.3 (11.2-17.4) 18.3 (18.1-18.5) 2.8 (2.4-3.1) 5.8 (5.6-5.9) 14.4 (8.8-19.9) 1.0 (0.6-1.3) 2.3 (1.4-3.1) 5.3 (2.0-8.5) S. aureus Col. 1841 2.8 (2.4-3.1) 5.0 (4.0-5.9) 11.3 (7.1-15.5) 1.8 (1.4-2.2) 2.9 (2.4-3.4) 4.7 (3.0-6.3) 2.6 (1.1-4.0) 6.2 (1.1-11.2) 10.3 (1.8-18.8) S. aureus CCUG 35601 2.0 (1.4-2.5) 6.0 (5.1-6.9) 17.0 (16.6-17.3) 2.0 (1.3-2.6) 17.6 (17.6-17.6) 17.6 (17.6-17.6) 3.6 (3.0-4.2) 18.5 (18.1-18.9) 18.5 (18.1-18.4) E. coli ATCC 25922 2.8 (2.6-3.0) 7.7 (4.3-11.1) 12.2 (4.9-19.4) 3.3 (2.8-3.7) 4.2 (3.4-4.9) 14.2 (7.3-21.1) 3.1 (2.5-3.6) 6.2 (4.4-7.9) 20.2 (19.4-21) K. pneumoniae ATCC 13883 1.9 (1.9-1.9) 4.4 (4.4-4.4) 12.8 (9.4-16.1) 1.5 (1.2-1.8) 4.0 (3.2-4.8) 9.6 (6.9-12.2) 1.1 (0.6-1.5) 2.9 (2.9-2.9) 6.7 (6.5-6.9) P. aeruginosa ATCC 27853 1.1 (0.6-1.6) 7.5 (7.5-7.5) 14.6 (14.0-15.1) 1.1 (0.8-1.4) 2.8 (2.2-3.3) 6.4 (5.6-7.1) 2.5 (2.0-3.0) 10.5 (9.4-11.5) 14.0 (13.6-14.4) ↵ a Values are means of two experiments, with ranges in parentheses.
- TABLE 4.
SMEs of PGE-9509924, levofloxacin, and ciprofloxacin
Strain SMEa (h) at indicated multiple of the MIC PGE-9509924 Levofloxacin Ciprofloxacin 0.1 0.2 0.3 0.1 0.2 0.3 0.1 0.2 0.3 S. pneumoniae ATCC 6306 1.1 (0.6-1.6) 6.5 (2.4-10.5) 12.0 (5.3-18.6) 0.4 (0.3-0.4) 2.7 (2.3-3.1) 8.3 (7.5-9.0) 0.5 (0.5-0.5) 1.9 (1.8-2.0) 5.6 (4.6-6.5) S. pneumoniae R2151 2.2 (2.0-2.4) 4.8 (3.0-6.6) 8.7 (3.8-13.6) 1.3 (1.0-1.6) 5.6 (3.1-8.0) 10.8 (5.9-15.6) 0.8 (0.3-1.3) 3.3 (1.9-4.9) 8.9 (3.8-14.0) S. aureus ATCC 29213 1.3 (0.6-1.9) 7.4 (2.8-12.0) 15.8 (13.5-18.0) 0.3 (2.4-3.1) 1.3 (5.6-5.9) 9.9 (8.8-19.9) 0 (0-0) 0.5 (0.3-0.6) 1.0 (0.8-1.1) S. aureus Col. 184 0.8 (0.6-0.9) 1.9 (1.3-2.5) 3.6 (2.8-4.4) 0.2 (0-0.3) 1.0 (0.9-1.1) 1.4 (1.1-1.6) 0 (0-0) 0.1 (0-0.2) 0.3 (0-0.5) S. aureus CCUG 35601 0.9 (1.4-2.5) 2.0 (5.1-6.9) 8.9 (16.6-17.3) 0.6 (1.3-2.6) 10.5 (17.6-17.6) 18.7 (17.6-17.6) 0.7 (3.0-4.2) 9.7 (18.1-18.9) 18.3 (18.1-18.4) E. coli ATCC 25922 0 (0-0) 0.2 (0-0.3) 1.0 (0.5-1.4) 0.1 (0-0.1) 0.4 (0.3-0.4) 1.2 (0.8-1.6) 0.3 (0.3-0.3) 1.2 (0.8-1.6) 13 (5-21) K. pneumoniae ATCC 13883 0.4 (0.3-0.4) 2.4 (1.9-2.9) 13.4 (10.6-16.1) 0.2 (0-0.3) 2.0 (1.3-2.6) 9.4 (8.8-10.0) 0.5 (0.4-0.6) 1.9 (1.9-1.9) 6.4 (6.3-6.4) P. aeruginosa ATCC 27853 0.9 (0.4-1.3) 9.9 (6.4-13.3) 14.4 (13.3-15.4) 0.6 (0.3-0.9) 2.3 (2.0-2.5) 4.0 (2.9-5.0) 1.0 (0-1.9) 8.4 (4.0-12.8) 13.4 (12.8-14.0) ↵ a Values are means of two experiments, with ranges in parentheses.
