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Mechanisms of Resistance

G484S Amino Acid Substitution in Lanosterol 14-α Demethylase (ERG11) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate

Laura Rodero, Emilia Mellado, A. Carolina Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca-Estrella, Graciela Davel, Juan L. Rodriguez-Tudela
Laura Rodero
1Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. Carlos G. Malbrán,”
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  • For correspondence: lrodero@anlis.gov.ar
Emilia Mellado
2Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
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A. Carolina Rodriguez
1Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. Carlos G. Malbrán,”
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Angela Salve
1Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. Carlos G. Malbrán,”
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Liliana Guelfand
3Hospital J. A. Fernandez, Buenos Aires, Argentina
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Pedro Cahn
3Hospital J. A. Fernandez, Buenos Aires, Argentina
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Manuel Cuenca-Estrella
2Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
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Graciela Davel
1Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. Carlos G. Malbrán,”
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Juan L. Rodriguez-Tudela
2Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
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DOI: 10.1128/AAC.47.11.3653-3656.2003
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Article Information

DOI 
https://doi.org/10.1128/AAC.47.11.3653-3656.2003
PubMed 
14576140

Published By 
American Society for Microbiology Journals
History 
  • Received May 2, 2003
  • Returned for modification June 10, 2003
  • Accepted August 11, 2003
  • Published online October 23, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. Laura Rodero1*,
  2. Emilia Mellado2,
  3. A. Carolina Rodriguez1,
  4. Angela Salve1,
  5. Liliana Guelfand3,
  6. Pedro Cahn3,
  7. Manuel Cuenca-Estrella2,
  8. Graciela Davel1 and
  9. Juan L. Rodriguez-Tudela2
  1. 1Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. Carlos G. Malbrán,”
  2. 3Hospital J. A. Fernandez, Buenos Aires, Argentina
  3. 2Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
  • ↵* Corresponding author. Mailing address: Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. Carlos G. Malbrán,” Av. Velez Sarsfield 563, (1281) Buenos Aires, Argentina. Phone and fax: 54-11-4302-5066. E-mail: lrodero{at}anlis.gov.ar .
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G484S Amino Acid Substitution in Lanosterol 14-α Demethylase (ERG11) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate
Laura Rodero, Emilia Mellado, A. Carolina Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca-Estrella, Graciela Davel, Juan L. Rodriguez-Tudela
Antimicrobial Agents and Chemotherapy Oct 2003, 47 (11) 3653-3656; DOI: 10.1128/AAC.47.11.3653-3656.2003

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G484S Amino Acid Substitution in Lanosterol 14-α Demethylase (ERG11) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate
Laura Rodero, Emilia Mellado, A. Carolina Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca-Estrella, Graciela Davel, Juan L. Rodriguez-Tudela
Antimicrobial Agents and Chemotherapy Oct 2003, 47 (11) 3653-3656; DOI: 10.1128/AAC.47.11.3653-3656.2003
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  • Top
  • Article
    • ABSTRACT
    • Clinical case.
    • Microdilution method.
    • E-test method.
    • Strain typing.
    • Mutation detection.
    • Cloning and plasmids.
    • Sequence analysis.
    • Development of resistance to FCZ.
    • Nucleotide sequence accession number.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
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KEYWORDS

antifungal agents
Cryptococcus neoformans
Cytochrome P-450 Enzyme System
Drug Resistance, Fungal
fluconazole
Meningitis, Cryptococcal
Oxidoreductases

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