DOI: 10.1128/AAC.47.11.3672-3673.2003
Article Figures & Data
Tables
- TABLE 1.
PZase activity and changes in the pncA gene for 76 clinical M. tuberculosis isolates
Isolate PZA MIC (μg/ml) PZase activity after: Change in: 7 days 14 days Nucleotide(s) Amino acid(s) 1 >300 − − C→T at position 401 F134→F 2 >300 − − G→A at position 290 G97→D 3 >300 − − G→C at position 281 F94→S 4-5 >300 − − T→G at position 464 V155→G 6 >300 − − 352-358 deletion Frameshift 7 >300 − − 397 insert G Frameshift 8 300 − − None Not applicable 9 >300 − + None Not applicable 10-11 >300 + + None Not applicable 12-17 300 + + None Not applicable 18-76 ≤100 + + None Not applicable - TABLE 2.
Frequency of PZA-susceptible strains according to frequency of susceptibility to first-line drugs
Characteristics of resistance to first-line drugs other than PZA No. of strains No. (%) of strains with PZA: Susceptibility (MIC ≤ 100) Resistance MIC = 300 MIC > 300 No resistance 27 25 (92.6) 1 (3.7) 1 (3.7) Resistance to all drugs tested 21 18 (85.7) 2 (9.5) 1 (4.8) MDR 28 16 (57.1) 4 (14.3) 8 (25.6)
