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Mechanisms of Resistance

Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei

Takashi Fukuoka, Douglas A. Johnston, Carol A. Winslow, Marcel J. de Groot, Catherine Burt, Christopher A. Hitchcock, Scott G. Filler
Takashi Fukuoka
1Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502
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Douglas A. Johnston
1Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502
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Carol A. Winslow
2Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, United Kingdom
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Marcel J. de Groot
2Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, United Kingdom
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Catherine Burt
2Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, United Kingdom
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Christopher A. Hitchcock
2Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, United Kingdom
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Scott G. Filler
1Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502
3UCLA School of Medicine, Los Angeles, California 90024
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  • For correspondence: sfiller@ucla.edu
DOI: 10.1128/AAC.47.4.1213-1219.2003
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Article Information

DOI 
https://doi.org/10.1128/AAC.47.4.1213-1219.2003
PubMed 
12654649

Published By 
American Society for Microbiology Journals
History 
  • Received August 23, 2002
  • Returned for modification October 1, 2002
  • Accepted December 23, 2002
  • Published online April 1, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. Takashi Fukuoka1†,
  2. Douglas A. Johnston1,
  3. Carol A. Winslow2,
  4. Marcel J. de Groot2,
  5. Catherine Burt2,
  6. Christopher A. Hitchcock2 and
  7. Scott G. Filler1,3*
  1. 1Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502
  2. 2Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, United Kingdom
  3. 3UCLA School of Medicine, Los Angeles, California 90024
  • ↵† Present address: Biological Research Laboratories, Sankyo, Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan.

  • ↵* Corresponding author. Mailing address: Division of Infectious Diseases, Harbor-UCLA Research and Education Institute, Bldg. RB-2, 1124 West Carson St., Torrance, CA 90502. Phone: (310) 222-6426. Fax: (310) 782-2016. E-mail: sfiller{at}ucla.edu .

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Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei
Takashi Fukuoka, Douglas A. Johnston, Carol A. Winslow, Marcel J. de Groot, Catherine Burt, Christopher A. Hitchcock, Scott G. Filler
Antimicrobial Agents and Chemotherapy Apr 2003, 47 (4) 1213-1219; DOI: 10.1128/AAC.47.4.1213-1219.2003

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Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei
Takashi Fukuoka, Douglas A. Johnston, Carol A. Winslow, Marcel J. de Groot, Catherine Burt, Christopher A. Hitchcock, Scott G. Filler
Antimicrobial Agents and Chemotherapy Apr 2003, 47 (4) 1213-1219; DOI: 10.1128/AAC.47.4.1213-1219.2003
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KEYWORDS

antifungal agents
Candida
Enzyme Inhibitors
fluconazole
Pyrimidines
triazoles

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