Article Figures & Data
Figures
- FIG. 1.
In vitro population analysis of S. aureus Lim-1 and Lim-2 on vancomycin (A) and teicoplanin (B) agar. Population analyses were performed with overnight cultures (∼108 to 109 CFU/ml) that were serially diluted and plated onto BHI agar containing increasing concentrations of vancomycin (0 to 10 μg/ml) or teicoplanin (0 to 40 μg/ml) and incubated for 48 h at 37°C before enumeration of the CFU.
- FIG. 2.
Time-kill curve studies with vancomycin (Vm) (A) and teicoplanin (Tc) (B) at various concentrations against S. aureus Lim-1 and Lim-2.
- FIG. 3.
Ex vivo population analysis of S. aureus Lim-1 (A) and Lim-2 (B) on vancomycin agar. The two strains were from the vegetations of six different infected rabbits sampled at the start of therapy.
Tables
- TABLE 1.
Efficacies of 4-day antibiotic regimens for treatment of experimental endocarditis due to S. aureus
Treatment Regimen Mean ± log10 CFU/g of vegetation (no. of sterile vegetations/total no. of vegetations) for strain: Lim-1 Lim-2 None (start-of- therapy controls) 9.4 ± 0.9 (0/14) 9.2 ± 1.3 (0/11) Vancomycin Standard dose 40 mg/kg every 12 h 7.0 ± 2.3a (1/8) 6.5 ± 2.4a (1/8) High dose 50 mg/kg every 8 h 6.2 ± 2.0a (2/10) 5.8 ± 2.8a (2/8) Teicoplanin Standard dose 20 mg/kg every 12 hb 6.1 ± 2.4a (1/8) 8.3 ± 1.9 (0/14) High dose 40 mg/kg q 12 hc Not done 7.0 ± 1.6a (0/9) - TABLE 2.
Concentrations of vancomycin and teicoplanin in the sera of three uninfected rabbits after the intramuscular administration of a single antibiotic dose
Regimen (dose [mg/kg]) Concn (μg/ml) in serum (time [h]) Peak Trough Vancomycin (40) 39 ± 12 (2) 12 ± 3 (12) Vancomycin (50) 45 ± 8 (2) 20 ± 5 (8) Teicoplanin (20) 44 ± 5 (4) 24 ± 1 (12) Teicoplanin (40) 95 ± 17 (4) 59 ± 21 (12)
