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Table of Contents

October 1, 2004; Volume 48,Issue 10

Minireviews

  • Minireview
    Antimicrobial Peptides from Marine Invertebrates
    J. Andy Tincu, Steven W. Taylor

Experimental Therapeutics

  • Experimental Therapeutics
    Telithromycin Treatment of Chronic Chlamydia pneumoniae Infection in C57BL/6J mice
    Liisa Törmäkangas, Hannu Alakärppä, Denise Bem David, Maija Leinonen, Pekka Saikku
  • Experimental Therapeutics
    Antifungal Therapy of Murine Aspergillus terreus Infection
    John R. Graybill, Steve Hernandez, Rosie Bocanegra, Laura K. Najvar
  • Experimental Therapeutics
    Antifungal Activities of Posaconazole and Granulocyte-Macrophage Colony-Stimulating Factor Ex Vivo and in Mice with Disseminated Infection Due to Scedosporium prolificans
    M. Simitsopoulou, C. Gil-Lamaignere, N. Avramidis, A. Maloukou, S. Lekkas, E. Havlova, L. Kourounaki, D. Loebenberg, E. Roilides
  • Experimental Therapeutics
    Therapy of Experimental Pseudomonas Infections with a Nonreplicating Genetically Modified Phage
    Steven Hagens, André Habel, Uwe von Ahsen, Alexander von Gabain, Udo Bläsi
  • Experimental Therapeutics
    Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis
    Philippe Cottagnoud, Marc Pfister, Fernando Acosta, Marianne Cottagnoud, Lukas Flatz, Felix Kühn, Hans-Peter Müller, Armin Stucki
  • Experimental Therapeutics
    Efficacy of PLD-118, a Novel Inhibitor of Candida Isoleucyl-tRNA Synthetase, against Experimental Oropharyngeal and Esophageal Candidiasis Caused by Fluconazole-Resistant C. albicans
    Vidmantas Petraitis, Ruta Petraitiene, Amy M. Kelaher, Alia A. Sarafandi, Tin Sein, Diana Mickiene, John Bacher, Andreas H. Groll, Thomas J. Walsh
  • Experimental Therapeutics
    Rifalazil Treats and Prevents Relapse of Clostridium difficile-Associated Diarrhea in Hamsters
    Pauline M. Anton, Michael O'Brien, Efi Kokkotou, Barry Eisenstein, Arthur Michaelis, David Rothstein, Sophia Paraschos, Ciáran P. Kelly, Charalabos Pothoulakis
  • Experimental Therapeutics
    Correlation between In Vitro Susceptibility of Scedosporium apiospermum to Voriconazole and In Vivo Outcome of Scedosporiosis in Guinea Pigs
    Javier Capilla, Josep Guarro
  • Experimental Therapeutics
    In Vitro Killing of Community-Associated Methicillin-Resistant Staphylococcus aureus with Drug Combinations
    Samuel A. Shelburne, Daniel M. Musher, Kristina Hulten, Heather Ceasar, Michael Y. Lu, Imran Bhaila, Richard J. Hamill
  • Experimental Therapeutics
    Sequential Therapy with Caspofungin and Fluconazole for Candida albicans Infection
    Francesco Barchiesi, Elisabetta Spreghini, Isabella Baldassarri, Anna Marigliano, Daniela Arzeni, Daniele Giannini, Giorgio Scalise
  • Experimental Therapeutics
    Efficacy of Posaconazole in a Murine Model of Central Nervous System Aspergillosis
    Jackie K. Imai, Gaurav Singh, Karl V. Clemons, David A. Stevens

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Multilayer Polyelectrolyte Films Functionalized by Insertion of Defensin: a New Approach to Protection of Implants from Bacterial Colonization
    O. Etienne, C. Picart, C. Taddei, Y. Haikel, J. L. Dimarcq, P. Schaaf, J. C. Voegel, J. A. Ogier, C. Egles
  • Mechanisms of Action: Physiological Effects
    Ketolide Antimicrobial Activity Persists after Disruption of Interactions with Domain II of 23S rRNA
    Guy W. Novotny, Lene Jakobsen, Niels M. Andersen, Jacob Poehlsgaard, Stephen Douthwaite
  • Mechanisms of Action: Physiological Effects
    Posaconazole Is a Potent Inhibitor of Sterol 14α-Demethylation in Yeasts and Molds
    Hanan K. Munayyer, Paul A. Mann, Andrew S. Chau, Taisa Yarosh-Tomaine, Jonathan R. Greene, Roberta S. Hare, Larry Heimark, Robert E. Palermo, David Loebenberg, Paul M. McNicholas
  • Mechanisms of Action: Physiological Effects
    Caspofungin Uptake Is Mediated by a High-Affinity Transporter in Candida albicans
    Padmaja Paderu, Steven Park, David S. Perlin
  • Mechanisms of Action: Physiological Effects
    Genomic Approach to Identification of Mutations Affecting Caspofungin Susceptibility in Saccharomyces cerevisiae
    Sarit Markovich, Aya Yekutiel, Itamar Shalit, Yona Shadkchan, Nir Osherov
  • Mechanisms of Action: Physiological Effects
    DB75, a Novel Trypanocidal Agent, Disrupts Mitochondrial Function in Saccharomyces cerevisiae
    Charlotte A. Lanteri, Bernard L. Trumpower, Richard R. Tidwell, Steven R. Meshnick
  • Mechanisms of Action: Physiological Effects
    The Antiparasitic Compound Licochalcone A Is a Potent Echinocytogenic Agent That Modifies the Erythrocyte Membrane in the Concentration Range Where Antiplasmodial Activity Is Observed
    Hanne L. Ziegler, Harald S. Hansen, Dan Stærk, Søren Brøgger Christensen, Henry Hägerstrand, Jerzy W. Jaroszewski

Pharmacology

  • Pharmacology
    Pharmacodynamic Functions: a Multiparameter Approach to the Design of Antibiotic Treatment Regimens
    Roland R. Regoes, Camilla Wiuff, Renata M. Zappala, Kim N. Garner, Fernando Baquero, Bruce R. Levin
  • Pharmacology
    Ertapenem Pharmacokinetics and Impact on Intestinal Microflora, in Comparison to Those of Ceftriaxone, after Multiple Dosing in Male and Female Volunteers
    Mathias W. R. Pletz, Mareike Rau, Juergen Bulitta, Andres De Roux, Olaf Burkhardt, Guido Kruse, Michael Kurowski, Carl E. Nord, Hartmut Lode
  • Pharmacology
    [18F]Ciprofloxacin, a New Positron Emission Tomography Tracer for Noninvasive Assessment of the Tissue Distribution and Pharmacokinetics of Ciprofloxacin in Humans
    Martin Brunner, Oliver Langer, Georg Dobrozemsky, Ulrich Müller, Markus Zeitlinger, Markus Mitterhauser, Wolfgang Wadsak, Robert Dudczak, Kurt Kletter, Markus Müller
  • Pharmacology
    Novel Concentration-Killing Curve Method for Estimation of Bactericidal Potency of Antibiotics in an In Vitro Dynamic Model
    Y. Q. Liu, Y. Z. Zhang, P. J. Gao
  • Pharmacology
    Long Depletion Time of Enrofloxacin in Rainbow Trout (Oncorhynchus mykiss)
    Dario Lucchetti, Laura Fabrizi, Emilio Guandalini, Elisabetta Podestà, Luigi Marvasi, Anna Zaghini, Ettore Coni

Antiviral Agents

  • Antiviral Agents
    A Series of Diaryltriazines and Diarylpyrimidines Are Highly Potent Nonnucleoside Reverse Transcriptase Inhibitors with Possible Applications as Microbicides
    Yven Van Herrewege, Guido Vanham, Jo Michiels, Katrien Fransen, Luc Kestens, Koen Andries, Paul Janssen, Paul Lewi
  • Antiviral Agents
    Combinations of Adefovir with Nucleoside Analogs Produce Additive Antiviral Effects against Hepatitis B Virus In Vitro
    William E. Delaney, Huiling Yang, Michael D. Miller, Craig S. Gibbs, Shelly Xiong
  • Antiviral Agents
    Liquid Chromatography Assay for Routine Monitoring of Cellular Ribavirin Levels in Blood
    Yoichi Inoue, Masato Homma, Yasushi Matsuzaki, Minoru Shibata, Takuya Matsumura, Takayoshi Ito, Keiji Mitamura, Naomi Tanaka, Yukinao Kohda
  • Antiviral Agents
    In Vitro Comparison of Topical Microbicides for Prevention of Human Immunodeficiency Virus Type 1 Transmission
    Charlene S. Dezzutti, V. Nicole James, Artur Ramos, Sharon T. Sullivan, Aladin Siddig, Timothy J. Bush, Lisa A. Grohskopf, Lynn Paxton, Shambavi Subbarao, Clyde E. Hart
  • Antiviral Agents
    Mannose-Specific Plant Lectins from the Amaryllidaceae Family Qualify as Efficient Microbicides for Prevention of Human Immunodeficiency Virus Infection
    Jan Balzarini, Sigrid Hatse, Kurt Vermeire, Katrien Princen, Stefano Aquaro, Carlo-Federico Perno, Erik De Clercq, Herman Egberink, Guy Vanden Mooter, Willy Peumans, Els Van Damme, Dominique Schols
  • Antiviral Agents
    Inhibition of Human Cytomegalovirus Replication by Benzimidazole Nucleosides Involves Three Distinct Mechanisms
    David L. Evers, Gloria Komazin, Roger G. Ptak, Dongjin Shin, Brian T. Emmer, Leroy B. Townsend, John C. Drach
  • Antiviral Agents
    A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties
    David B. Olsen, Anne B. Eldrup, Linda Bartholomew, Balkrishen Bhat, Michele R. Bosserman, Alessandra Ceccacci, Lawrence F. Colwell, John F. Fay, Osvaldo A. Flores, Krista L. Getty, Jay A. Grobler, Robert L. LaFemina, Eric J. Markel, Giovanni Migliaccio, Marija Prhavc, Mark W. Stahlhut, Joanne E. Tomassini, Malcolm MacCoss, Daria J. Hazuda, Steven S. Carroll
  • Antiviral Agents
    Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin
    Jim Zhen Wu, Gary Larson, Zhi Hong

Susceptibility

  • Susceptibility
    Antimicrobial Evaluation of Nocathiacins, a Thiazole Peptide Class of Antibiotics
    Michael J. Pucci, Joanne J. Bronson, John F. Barrett, Kenneth L. DenBleyker, Linda F. Discotto, Joan C. Fung-Tomc, Yasutsugu Ueda
  • Susceptibility
    In Vitro Activities of 2,4-Diaminoquinazoline and 2,4-Diaminopteridine Derivatives against Plasmodium falciparum
    Sheila Ommeh, Eunice Nduati, Eddy Mberu, Gilbert Kokwaro, Kevin Marsh, Andre Rosowsky, Alexis Nzila
  • Susceptibility
    Effect of Glycine on Helicobacter pylori In Vitro
    Masaaki Minami, Takafumi Ando, Shin-nosuke Hashikawa, Keizo Torii, Tadao Hasegawa, Dawn A. Israel, Kenji Ina, Kazuo Kusugami, Hidemi Goto, Michio Ohta
  • Susceptibility
    Antimicrobial Activity of Euplotin C, the Sesquiterpene Taxonomic Marker from the Marine Ciliate Euplotes crassus
    Dianella Savoia, Claudio Avanzini, Tiziano Allice, Emanuela Callone, Graziano Guella, Fernando Dini
  • Susceptibility
    Determination of Susceptibilities of 26 Leptospira sp. Serovars to 24 Antimicrobial Agents by a Broth Microdilution Technique
    Clinton K. Murray, Duane R. Hospenthal
  • Susceptibility
    Antipneumococcal Activity of LBM415, a New Peptide Diformylase Inhibitor, Compared with Those of Other Agents
    Lois M. Ednie, Glenn Pankuch, Peter C. Appelbaum
  • Susceptibility
    Antistaphylococcal Activity of LBM415, a New Peptide Deformylase Inhibitor, Compared with Those of Other Agents
    Kim Credito, Gengrong Lin, Lois M. Ednie, Peter C. Appelbaum
  • Susceptibility
    Antistaphylococcal Activity of CB-181963 (CAB-175), an Experimental Parenteral Cephalosporin
    Dianne B. Hoellman, Glenn A. Pankuch, Peter C. Appelbaum

Clinical Therapeutics

  • Clinical Therapeutics
    Epidemiology and Clinical Features of Bloodstream Infections Caused by AmpC-Type-β-Lactamase-Producing Klebsiella pneumoniae
    Hyunjoo Pai, Cheol-In Kang, Jeong-Hum Byeon, Ki-Deok Lee, Wan Beom Park, Hong-Bin Kim, Eui-Chong Kim, Myoung-don Oh, Kang-Won Choe
  • Clinical Therapeutics
    Population Pharmacokinetics of Pyrimethamine and Sulfadoxine in Children Treated for Congenital Toxoplasmosis
    Stéphane Corvaisier, Bruno Charpiat, Cyril Mounier, Martine Wallon, Gilles Leboucher, Mounzer Al Kurdi, Jean-François Chaulet, François Peyron
  • Clinical Therapeutics
    Intrapulmonary Pharmacokinetics and Pharmacodynamics of Itraconazole and 14-Hydroxyitraconazole at Steady State
    John E. Conte, Jeffrey A. Golden, Juliana Kipps, Marina McIver, Elisabeth Zurlinden
  • Clinical Therapeutics
    Combination Therapy Counteracts the Enhanced Transmission of Drug-Resistant Malaria Parasites to Mosquitoes
    Rachel L. Hallett, Colin J. Sutherland, Neal Alexander, Rosalynn Ord, Musa Jawara, Chris J. Drakeley, Margaret Pinder, Gijs Walraven, Geoffrey A. T. Targett, Ali Alloueche

Mechanisms of Resistance

  • Mechanisms of Resistance
    AcrAB-TolC Directs Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium DT104
    Sylvie Baucheron, Shaun Tyler, David Boyd, Michael R. Mulvey, Elisabeth Chaslus-Dancla, Axel Cloeckaert
  • Mechanisms of Resistance
    Emergence and Spread of Three Clonally Related Virulent Isolates of CTX-M-15-Producing Escherichia coli with Variable Resistance to Aminoglycosides and Tetracycline in a French Geriatric Hospital
    Véronique Leflon-Guibout, Cécile Jurand, Stéphane Bonacorsi, Florence Espinasse, Marie Claude Guelfi, Françoise Duportail, Beate Heym, Edouard Bingen, Marie-Hélène Nicolas-Chanoine
  • Mechanisms of Resistance
    Acquired Bacitracin Resistance in Enterococcus faecalis Is Mediated by an ABC Transporter and a Novel Regulatory Protein, BcrR
    Janet M. Manson, Stefanie Keis, John M. B. Smith, Gregory M. Cook
  • Mechanisms of Resistance
    Cell Wall Composition and Decreased Autolytic Activity and Lysostaphin Susceptibility of Glycopeptide-Intermediate Staphylococcus aureus
    Jennifer L. Koehl, Arunachalam Muthaiyan, Radheshyam K. Jayaswal, Kerstin Ehlert, Harald Labischinski, Brian J. Wilkinson
  • Mechanisms of Resistance
    Complete Nucleotide Sequence of a 92-Kilobase Plasmid Harboring the CTX-M-15 Extended-Spectrum Beta-Lactamase Involved in an Outbreak in Long-Term-Care Facilities in Toronto, Canada
    David A. Boyd, Shaun Tyler, Sara Christianson, Allison McGeer, Matthew P. Muller, Barbara M. Willey, Elizabeth Bryce, Michael Gardam, Patrice Nordmann, Michael R. Mulvey
    and Canadian Nosocomial Infection Surveillance Program, Health Canada
  • Mechanisms of Resistance
    Azole Resistance in Candida glabrata: Coordinate Upregulation of Multidrug Transporters and Evidence for a Pdr1-Like Transcription Factor
    John-Paul Vermitsky, Thomas D. Edlind
  • Mechanisms of Resistance
    Increasing Prevalence of Quinolone Resistance in Human Nontyphoid Salmonella enterica Isolates Obtained in Spain from 1981 to 2003
    José M. Marimón, María Gomáriz, Carmen Zigorraga, Gustavo Cilla, Emilio Pérez-Trallero
  • Mechanisms of Resistance
    Variant Salmonella Genomic Island 1 Antibiotic Resistance Gene Cluster Containing a Novel 3′-N-Aminoglycoside Acetyltransferase Gene Cassette, aac(3)-Id, in Salmonella enterica Serovar Newport
    Benoît Doublet, François-Xavier Weill, Laetitia Fabre, Elisabeth Chaslus-Dancla, Axel Cloeckaert
  • Mechanisms of Resistance
    Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium Have Low Levels of Heme and a Reduced Rate of Respiration and Are Sensitive to Oxidative Stress
    Mirjana Macvanin, Andras Ballagi, Diarmaid Hughes
  • Mechanisms of Resistance
    VanD-Type Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis
    Florence Depardieu, Mathias Kolbert, Hendrik Pruul, Jan Bell, Patrice Courvalin
  • Mechanisms of Resistance
    Mechanism of Resistance to Several Antimicrobial Agents in Salmonella Clinical Isolates Causing Traveler's Diarrhea
    Roberto Cabrera, Joaquím Ruiz, Francesc Marco, Inés Oliveira, Margarita Arroyo, Ana Aladueña, Miguel A. Usera, M. Teresa Jiménez De Anta, Joaquím Gascón, Jordi Vila
  • Mechanisms of Resistance
    Mutant Prevention Concentrations for Single-Step Fluoroquinolone-Resistant Mutants of Wild-Type, Efflux-Positive, or ParC or GyrA Mutation-Containing Streptococcus pneumoniae Isolates
    Heather J. Smith, Michael Walters, Tamiko Hisanaga, George G. Zhanel, Daryl J. Hoban
  • Mechanisms of Resistance
    Antibody Mapping of the Linear Epitopes of CMY-2 and SHV-1 β-Lactamases
    Andrea M. Hujer, Christopher R. Bethel, Robert A. Bonomo
  • Mechanisms of Resistance
    Tetracycline Resistance in Chlamydia suis Mediated by Genomic Islands Inserted into the Chlamydial inv-Like Gene
    Jae Dugan, Daniel D. Rockey, Loren Jones, Arthur A. Andersen
  • Mechanisms of Resistance
    Mechanisms of Resistance in Multiple-Antibiotic-Resistant Escherichia coli Strains of Human, Animal, and Food Origins
    Yolanda Sáenz, Laura Briñas, Elena Domínguez, Joaquim Ruiz, Myriam Zarazaga, Jordi Vila, Carmen Torres
  • Mechanisms of Resistance
    Prevalence of Mutations within the Quinolone Resistance-Determining Region of gyrA, gyrB, parC, and parE and Association with Antibiotic Resistance in Quinolone-Resistant Salmonella enterica
    Deborah J. Eaves, Luke Randall, Douglas T. Gray, Antony Buckley, Martin J. Woodward, Allan P. White, Laura J. V. Piddock
  • Mechanisms of Resistance
    Alterations of Penicillin-Binding Proteins 1A, 2X, and 2B in Streptococcus pneumoniae Isolates for Which Amoxicillin MICs Are Higher than Penicillin MICs
    K. Kosowska, M. R. Jacobs, S. Bajaksouzian, L. Koeth, P. C. Appelbaum
  • Mechanisms of Resistance
    Peptide Nucleic Acid-Mediated Competitive PCR Clamping for Detection of Rifampin-Resistant Mycobacterium tuberculosis
    Tomotada Iwamoto, Toshiaki Sonobe
  • Mechanisms of Resistance
    Resistance Phenotypes and Genotypes of Erythromycin-Resistant Streptococcus pneumoniae Isolates in Beijing and Shenyang, China
    Zhao Tiemei, Fang Xiangqun, Liu Youning
  • Mechanisms of Resistance
    CARB-9, a Carbenicillinase Encoded in the VCR Region of Vibrio cholerae Non-O1, Non-O139 Belongs to a Family of Cassette-Encoded β-Lactamases
    Alejandro Petroni, Roberto G. Melano, Héctor A. Saka, Alicia Garutti, Laura Mange, Fernando Pasterán, Melina Rapoport, Mariana Miranda, Diego Faccone, Alicia Rossi, Paul S. Hoffman, Marcelo F. Galas
  • Mechanisms of Resistance
    Relationship between Phenotypic and Genotypic Florfenicol Resistance in Escherichia coli
    Randall S. Singer, Sheila K. Patterson, Anne E. Meier, Jessica K. Gibson, Hannah L. Lee, Carol W. Maddox
  • Mechanisms of Resistance
    AmpC β-Lactamase in an Escherichia coli Clinical Isolate Confers Resistance to Expanded-Spectrum Cephalosporins
    Hedi Mammeri, Hasan Nazic, Thierry Naas, Laurent Poirel, Sophie Léotard, Patrice Nordmann
  • Mechanisms of Resistance
    Novel Resistance-Nodulation-Cell Division Efflux System AdeDE in Acinetobacter Genomic DNA Group 3
    Sze-Lok Chau, Yiu-Wai Chu, Elizabeth T. S. Houang
  • Mechanisms of Resistance
    Rapid Detection and Sequence-Specific Differentiation of Extended-Spectrum β-Lactamase GES-2 from Pseudomonas aeruginosa by Use of a Real-Time PCR Assay
    Gerhard F. Weldhagen

Biologic Response Modifiers

  • Biologic Response Modifiers
    Human Immunodeficiency Virus Type 1 Protease Inhibitors Block Toll-Like Receptor 2 (TLR2)- and TLR4-Induced NF-κB Activation
    Ozlem Equils, Alan Shapiro, Zeynep Madak, Chunren Liu, Daning Lu

Errata

  • Errata
    Challenges in Designing Animal Studies To Detect Antagonism of Polyene Activity
    Russell E. Lewis, Dimitrios P. Kontoyiannis
  • Errata
    Penetration of Candida Biofilms by Antifungal Agents
    Mohammed A. Al-Fattani, L. Julia Douglas
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Antimicrobial Agents and Chemotherapy: 48 (10)

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  • Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2
  • Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
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