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Susceptibility

Antimicrobial Activity of Euplotin C, the Sesquiterpene Taxonomic Marker from the Marine Ciliate Euplotes crassus

Dianella Savoia, Claudio Avanzini, Tiziano Allice, Emanuela Callone, Graziano Guella, Fernando Dini
Dianella Savoia
1Department of Clinical and Biological Sciences, University of Turin, Turin
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  • For correspondence: dianella.savoia@unito.it
Claudio Avanzini
1Department of Clinical and Biological Sciences, University of Turin, Turin
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Tiziano Allice
1Department of Clinical and Biological Sciences, University of Turin, Turin
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Emanuela Callone
2Department of Physics, University of Trento, Trento
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Graziano Guella
2Department of Physics, University of Trento, Trento
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Fernando Dini
3Department of Ethology, Ecology and Evolution, University of Pisa, Pisa, Italy
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DOI: 10.1128/AAC.48.10.3828-3833.2004
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  • FIG. 1.
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    FIG. 1.

    Chemical structure of EC, the compound used in this study.

  • FIG. 2.
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    FIG. 2.

    Inhibitory effects of EC complex 1 (at 100 and 20 μg/ml) and the solvent DMSO (at 0.1 and 0.02%) on the growth of L. major and L. infantum after 2, 24, and 48 h of contact. Percentages were calculated relative to the growth of promastigotes in medium, considered as 100%.

  • FIG. 3.
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    FIG. 3.

    Inhibitory effects of EC complex 1 and DMSO (A) and of EC complex 2 and DIMEB (B) on the growth of E. vannus strain TB6.

  • FIG. 4.
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    FIG. 4.

    Effects of the two Euplotes strains on the viability of L. major and L. infantum. (A) E. crassus strain SSt22 (euplotin-producing strain); (B) E. vannus strain TB6 (non-euplotin-producing strain). The Euplotes strains remained viable for the duration of the experiment.

Tables

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  • TABLE 1.

    Inhibitory and killing activities of EC against L. major at different times

    EC complex% Activitya of EC at the indicated time and concn against L. major
    After 2 hAfter 24 hAfter 48 h
    100 μg/ml20 μg/ml100 μg/ml20 μg/ml100 μg/ml20 μg/ml
    ABABABABABAB
    19492666010010097921001005651
    283784239959272691001009085
    • ↵ a A, inhibitory activity, B, killing activity.

  • TABLE 2.

    Antimicrobial activities of the two complexes of EC and the two solvents against different microorganismsa

    Microorganism% of vital microorganisms after treatment with:
    Complex 1DMSOComplex 2DIMEB
    2 h24 h2 h24 h2 h24 h2 h24 h
    Gram-positive bacteria
        Micrococcus luteus ATCC 9341100100100100100100100100
        Staphylococcus aureus ATCC 6538100100100100100100100100
        Streptococcus pyogenes ATCC 11434404851510066100100
        Streptococcus pyogenes ATCC 8668100101008010070100100
    Gram-negative bacteria
        Escherichia coli HB101604865901008010092
        Proteus vulgaris N9100100100100100100100100
        Pseudomonas aeruginosa ATCC 1544295859590977210090
        Burkholderia cepacia ATCC 177593865559590100100
        Burkholderia cepacia 1/2000712459090100100
    Yeast, Candida albicans 617822560709490
    • ↵ a EC was used at 100 μg/ml. DMSO was used as a solvent with EC complex 1, and DIMEB was used as a solvent with EC complex 2.

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Antimicrobial Activity of Euplotin C, the Sesquiterpene Taxonomic Marker from the Marine Ciliate Euplotes crassus
Dianella Savoia, Claudio Avanzini, Tiziano Allice, Emanuela Callone, Graziano Guella, Fernando Dini
Antimicrobial Agents and Chemotherapy Sep 2004, 48 (10) 3828-3833; DOI: 10.1128/AAC.48.10.3828-3833.2004

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Antimicrobial Activity of Euplotin C, the Sesquiterpene Taxonomic Marker from the Marine Ciliate Euplotes crassus
Dianella Savoia, Claudio Avanzini, Tiziano Allice, Emanuela Callone, Graziano Guella, Fernando Dini
Antimicrobial Agents and Chemotherapy Sep 2004, 48 (10) 3828-3833; DOI: 10.1128/AAC.48.10.3828-3833.2004
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KEYWORDS

anti-infective agents
Euplotes
Sesquiterpenes

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