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Table of Contents

March 1, 2004; Volume 48,Issue 3

Minireviews

  • Minireview
    Combination Antifungal Therapy
    Melissa D. Johnson, Conan MacDougall, Luis Ostrosky-Zeichner, John R. Perfect, John H. Rex

Mechanisms of Resistance

  • Mechanisms of Resistance
    Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC β-Lactamase of a Serratia marcescens Clinical Isolate
    Hedi Mammeri, Laurent Poirel, Pascal Bemer, Henri Drugeon, Patrice Nordmann
  • Mechanisms of Resistance
    A Second Tylosin Resistance Determinant, Erm B, in Arcanobacterium pyogenes
    B. Helen Jost, Hien T. Trinh, J. Glenn Songer, Stephen J. Billington
  • Mechanisms of Resistance
    Isolation and Characterization of Integron-Containing Bacteria without Antibiotic Selection
    Robert S. Barlow, John M. Pemberton, Patricia M. Desmarchelier, Kari S. Gobius
  • Mechanisms of Resistance
    Selection of an Antibiotic-Hypersusceptible Mutant of Pseudomonas aeruginosa: Identification of the GlmR Transcriptional Regulator
    Julio Ramos-Aires, Patrick Plésiat, Lasta Kocjancic-Curty, Thilo Köhler
  • Mechanisms of Resistance
    Plasmodium falciparum Isolates in India Exhibit a Progressive Increase in Mutations Associated with Sulfadoxine-Pyrimethamine Resistance
    Anwar Ahmed, Deepak Bararia, Sumiti Vinayak, Mohammed Yameen, Sukla Biswas, Vas Dev, Ashwani Kumar, Musharraf A. Ansari, Yagya D. Sharma
  • Mechanisms of Resistance
    Tetracycline and Streptomycin Resistance Genes, Transposons, and Plasmids in Salmonella enterica Isolates from Animals in Italy
    Cristina Pezzella, Antonia Ricci, Elisabetta DiGiannatale, Ida Luzzi, Alessandra Carattoli
  • Mechanisms of Resistance
    Novel Chromosomally Encoded Multidrug Efflux Transporter MdeA in Staphylococcus aureus
    Jianzhong Huang, Paul W. O'Toole, Wei Shen, Heather Amrine-Madsen, Xinhe Jiang, Neethan Lobo, Leslie M. Palmer, LeRoy Voelker, Frank Fan, Michael N. Gwynn, Damien McDevitt
  • Mechanisms of Resistance
    Ribosomal Mutations in Arcanobacterium pyogenes Confer a Unique Spectrum of Macrolide Resistance
    B. Helen Jost, Hien T. Trinh, J. Glenn Songer, Stephen J. Billington
  • Mechanisms of Resistance
    Staphylococcus aureus Isolates with Reduced Susceptibility to Glycopeptides Belong to Accessory Gene Regulator Group I or II
    Isabelle Verdier, Marie-Elisabeth Reverdy, Jerome Etienne, Gérard Lina, Michèle Bes, François Vandenesch
  • Mechanisms of Resistance
    Role of attP in Integrase-Mediated Integration of the Shigella Resistance Locus Pathogenicity Island of Shigella flexneri
    Sally A. Turner, Shelley N. Luck, Harry Sakellaris, Kumar Rajakumar, Ben Adler
  • Mechanisms of Resistance
    In Vitro Evolution Predicts that the IMP-1 Metallo-β-Lactamase Does Not Have the Potential To Evolve Increased Activity against Imipenem
    Barry G. Hall
  • Mechanisms of Resistance
    Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical Isolate
    G. Barnaud, Y. Benzerara, J. Gravisse, L. Raskine, M. J. Sanson-Le Pors, R. Labia, G. Arlet

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria
    Alexey Ruzin, Guy Singh, Anatoly Severin, Youjun Yang, Russell G. Dushin, Alan G. Sutherland, Albert Minnick, Michael Greenstein, Michael K. May, David M. Shlaes, Patricia A. Bradford
  • Mechanisms of Action: Physiological Effects
    Miltefosine Induces Apoptosis-Like Death in Leishmania donovani Promastigotes
    Caroline Paris, Philippe M. Loiseau, Christian Bories, Jaqueline Bréard
  • Mechanisms of Action: Physiological Effects
    Killing by Ampicillin and Ofloxacin Induces Overlapping Changes in Escherichia coli Transcription Profile
    Niilo Kaldalu, Rui Mei, Kim Lewis
  • Mechanisms of Action: Physiological Effects
    Fluorescence Detection-Based Functional Assay for High-Throughput Screening for MraY
    Thérèse Stachyra, Christophe Dini, Paul Ferrari, Ahmed Bouhss, Jean van Heijenoort, Dominique Mengin-Lecreulx, Didier Blanot, Jacques Biton, Dominique Le Beller
  • Mechanisms of Action: Physiological Effects
    Interactions between Penicillin-Binding Proteins (PBPs) and Two Novel Classes of PBP Inhibitors, Arylalkylidene Rhodanines and Arylalkylidene Iminothiazolidin-4-ones
    Astrid Zervosen, Wei-Ping Lu, Zhouliang Chen, Ronald E. White, Thomas P. Demuth, Jean-Marie Frère
  • Mechanisms of Action: Physiological Effects
    Inhibitors of Antibiotic Efflux in Resistant Enterobacter aerogenes and Klebsiella pneumoniae Strains
    Jacqueline Chevalier, Jérôme Bredin, Abdallah Mahamoud, Monique Malléa, Jacques Barbe, Jean-Marie Pagès
  • Mechanisms of Action: Physiological Effects
    Inhibition of β-Lactamase II of Bacillus cereus by Penamaldic Derivatives of Penicillins
    Pilar Gutiérrez Navarro, Bartolomé Quintero Osso, Raquel García Ortiz, Pedro J. Martínez de las Parras, María I. Martínez Puentedura, M. Carmen Cabeza González

Susceptibility

  • Susceptibility
    Comparative In Vitro Activities of AC98-6446, a Novel Semisynthetic Glycopeptide Derivative of the Natural Product Mannopeptimycin α, and Other Antimicrobial Agents against Gram-Positive Clinical Isolates
    Peter J. Petersen, T. Z. Wang, Russell G. Dushin, Patricia A. Bradford
  • Susceptibility
    Antibiotic Susceptibility of Tropheryma whipplei in MRC5 Cells
    Areen Boulos, Jean-Marc Rolain, Didier Raoult
  • Susceptibility
    In Vitro Double and Triple Synergistic Activities of Polymyxin B, Imipenem, and Rifampin against Multidrug-Resistant Acinetobacter baumannii
    Jimmy Yoon, Carl Urban, Christian Terzian, Noriel Mariano, James J. Rahal
  • Susceptibility
    In Vitro and In Vivo Activities of Antimicrobials against Nocardia brasiliensis
    Alejandra Gomez-Flores, Oliverio Welsh, Salvador Said-Fernández, Gerardo Lozano-Garza, Roman Erick Tavarez-Alejandro, Lucio Vera-Cabrera
  • Susceptibility
    In Vitro Activities of 3-(Halogenated Phenyl)-5-Acyloxymethyl- 2,5-Dihydrofuran-2-ones against Common and Emerging Yeasts and Molds
    Vladimír Buchta, Milan Pour, Petra Kubanová, Luis Silva, Ivan Votruba, Marie Vopršálová, Radan Schiller, Helena Fáková, Marcel Špulák
  • Susceptibility
    In Vitro Evaluation of Double and Triple Combinations of Antifungal Drugs against Aspergillus fumigatus and Aspergillus terreus
    Eric Dannaoui, Olivier Lortholary, Françoise Dromer
  • Susceptibility
    In Vitro Activity of Daptomycin against Gram-Positive European Clinical Isolates with Defined Resistance Determinants
    Ad C. Fluit, Franz-Josef Schmitz, Jan Verhoef, Dana Milatovic
  • Susceptibility
    In Vitro Activities of Moxifloxacin against 900 Aerobic and Anaerobic Surgical Isolates from Patients with Intra-Abdominal and Diabetic Foot Infections
    Charles E. Edmiston, Candace J. Krepel, Gary R. Seabrook, Lewis R. Somberg, Atilla Nakeeb, Robert A. Cambria, Jonathan B. Towne
  • Susceptibility
    In Vitro Activities of Tigecycline against the Bacteroides fragilis Group
    N. V. Jacobus, L. A. McDermott, R. Ruthazer, D. R. Snydman
  • Susceptibility
    In Vitro Activities of New Quinolones and Oxazolidinones against Actinomadura madurae
    Lucio Vera-Cabrera, Elsa Y. Ochoa-Felix, Gloria Gonzalez, Rolando Tijerina, Sung H. Choi, Oliverio Welsh
  • Susceptibility
    Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii Clinical Isolates
    Rose Jung, Maroof Husain, Michael K. Choi, Douglas N. Fish

Experimental Therapeutics

  • Experimental Therapeutics
    Activity of Posaconazole Combined with Amphotericin B against Aspergillus flavus Infection in Mice: Comparative Studies in Two Laboratories
    Laura K. Najvar, Anthony Cacciapuoti, Steve Hernandez, Judith Halpern, Rosie Bocanegra, Maya Gurnani, Frederick Menzel, David Loebenberg, John R. Graybill
  • Experimental Therapeutics
    Activities of Garenoxacin against Quinolone-Resistant Streptococcus pneumoniae Strains In Vitro and in a Mouse Pneumonia Model
    E. Azoulay-Dupuis, J. P. Bédos, J. Mohler, G. Peytavin, R. Isturiz, P. Moine, V. Rieux, C. Cherbuliez, J. C. Péchère, B. Fantin, T. Köhler
  • Experimental Therapeutics
    Quantitative Evaluation of the Therapeutic Effects of Antibiotics Using Silkworms Infected with Human Pathogenic Microorganisms
    Hiroshi Hamamoto, Kenji Kurokawa, Chikara Kaito, Koushirou Kamura, Iony Manitra Razanajatovo, Hiroyuki Kusuhara, Tomofumi Santa, Kazuhisa Sekimizu
  • Experimental Therapeutics
    Effect of Antibiotic Treatment Delay on Therapeutic Outcome of Experimental Acute Otitis Media Caused by Streptococcus pneumoniae Strains with Different Susceptibilities to Amoxicillin
    Araceli Parra, Carmen Ponte, Carlos Cenjor, Carmen Martínez-Marín, Francisco Soriano
    and The Spanish Pneumococcal Infection Study Network
  • Experimental Therapeutics
    Activities of Ciprofloxacin and Moxifloxacin against Stenotrophomonas maltophilia and Emergence of Resistant Mutants in an In Vitro Pharmacokinetic-Pharmacodynamic Model
    Boubakar B. Ba, Hala Feghali, Corinne Arpin, Marie-Claude Saux, Claudine Quentin
  • Experimental Therapeutics
    Amphotericin B and Fluconazole, a Potent Combination Therapy for Cryptococcal Meningitis
    Robert A. Larsen, Madeline Bauer, Ann M. Thomas, J. Richard Graybill
  • Experimental Therapeutics
    Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models
    E. Dadachova, R. A. Bryan, A. Frenkel, T. Zhang, C. Apostolidis, J. S. Nosanchuk, J. D. Nosanchuk, A. Casadevall
  • Experimental Therapeutics
    Comparative Efficacies of Four Amphotericin B Formulations—Fungizone, Amphotec (Amphocil), AmBisome, and Abelcet—against Systemic Murine Aspergillosis
    Karl V. Clemons, David A. Stevens
  • Experimental Therapeutics
    Activities of Dalbavancin In Vitro and in a Rabbit Model of Experimental Endocarditis Due to Staphylococcus aureus with or without Reduced Susceptibility to Vancomycin and Teicoplanin
    Agnès Lefort, Juliette Pavie, Louis Garry, Françoise Chau, Bruno Fantin

Clinical Therapeutics

  • Clinical Therapeutics
    Early Bactericidal Activity of Moxifloxacin in Treatment of Pulmonary Tuberculosis: a Prospective, Randomized Study
    Mathias W. R. Pletz, Andres De Roux, Andreas Roth, Karl-Heinz Neumann, Harald Mauch, Hartmut Lode

Antiviral Agents

  • Antiviral Agents
    Effect of Zinc Salts on Respiratory Syncytial Virus Replication
    Rahaman O. Suara, James E. Crowe
  • Antiviral Agents
    Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir
    Eric S. Furfine, Christopher T. Baker, Michael R. Hale, David J. Reynolds, Jo A. Salisbury, Andy D. Searle, Scott D. Studenberg, Dan Todd, Roger D. Tung, Andrew Spaltenstein
  • Antiviral Agents
    Quality Assurance Program for Clinical Measurement of Antiretrovirals: AIDS Clinical Trials Group Proficiency Testing Program for Pediatric and Adult Pharmacology Laboratories
    Diane T. Holland, Robin DiFrancesco, Judith Stone, Fayez Hamzeh, James D. Connor, Gene D. Morse
  • Antiviral Agents
    Geldanamycin, a Ligand of Heat Shock Protein 90, Inhibits the Replication of Herpes Simplex Virus Type 1 In Vitro
    Yu-Huan Li, Pei-Zhen Tao, Yu-Zhen Liu, Jian-Dong Jiang
  • Antiviral Agents
    Pharmacokinetics of Indinavir and Nelfinavir in Treatment-Naive, Human Immunodeficiency Virus-Infected Subjects
    Robert DiCenzo, Alan Forrest, Margaret A. Fischl, Ann Collier, Judith Feinberg, Heather Ribaudo, Robin DiFrancecso, Gene D. Morse
    and the AIDS Clinical Trials Group 388/733/5060 Study Team
  • Antiviral Agents
    Molecular Mechanisms of Tenofovir Resistance Conferred by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing a Diserine Insertion after Residue 69 and Multiple Thymidine Analog-Associated Mutations
    Kirsten L. White, James M. Chen, Nicolas A. Margot, Terri Wrin, Christos J. Petropoulos, Lisa K. Naeger, S. Swaminathan, Michael D. Miller
  • Antiviral Agents
    Quantitative Analysis of a Parasitic Antiviral Strategy
    Hwijin Kim, John Yin

Pharmacology

  • Pharmacology
    New Findings on the Structure-Phototoxicity Relationship and Photostability of Fluoroquinolones with Various Substituents at Position 1
    Norihiro Hayashi, Yoshihiro Nakata, Akira Yazaki
  • Pharmacology
    Pharmacokinetics of Posaconazole Coadministered with Antacid in Fasting or Nonfasting Healthy Men
    Rachel Courtney, Elaine Radwanski, Josephine Lim, Mark Laughlin
  • Pharmacology
    Possible Involvement of the Drug Transporters P Glycoprotein and Multidrug Resistance-Associated Protein Mrp2 in Disposition of Azithromycin
    Masami Sugie, Emiko Asakura, Ying Lan Zhao, Shoko Torita, Masayuki Nadai, Kenji Baba, Kiyoyuki Kitaichi, Kenji Takagi, Kenzo Takagi, Takaaki Hasegawa
  • Pharmacology
    Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma
    Julie A. Stone, Xin Xu, Gregory A. Winchell, Paul J. Deutsch, Paul G. Pearson, Elizabeth M. Migoya, Goutam C. Mistry, Liwen Xi, Alisha Miller, Punam Sandhu, Romi Singh, Florencia deLuna, Stacy C. Dilzer, Kenneth C. Lasseter
  • Pharmacology
    Tolerability, Pharmacokinetics, and Serum Bactericidal Activity of Intravenous Dalbavancin in Healthy Volunteers
    Anton Leighton, Alice Bendix Gottlieb, Mary Beth Dorr, Daniela Jabes, Giorgio Mosconi, Claudia VanSaders, Edward J. Mroszczak, Kathleen C. M. Campbell, Ellen Kelly
  • Pharmacology
    Plasmodium falciparum-Based Bioassay for Measurement of Artemisinin Derivatives in Plasma or Serum
    Paktiya Teja-Isavadharm, James O. Peggins, Thomas G. Brewer, Nicholas J. White, H. Kyle Webster, Dennis E. Kyle
  • Pharmacology
    Intrapatient Variability of Efavirenz Concentrations as a Predictor of Virologic Response to Antiretroviral Therapy
    Richard C. Brundage, Florence H. Yong, Terence Fenton, Stephen A. Spector, Stuart E. Starr, Courtney V. Fletcher
  • Pharmacology
    Relative Bioavailability of Three Newly Developed Albendazole Formulations: a Randomized Crossover Study with Healthy Volunteers
    I. M. Rigter, H. G. Schipper, R. P. Koopmans, H. J. M. van Kan, H. W. Frijlink, P. A. Kager, H.-J. Guchelaar

Biologic Response Modifiers

  • Biologic Response Modifiers
    Quercetin Induces Apoptosis of Trypanosoma brucei gambiense and Decreases the Proinflammatory Response of Human Macrophages
    Maria Mamani-Matsuda, Jérôme Rambert, Denis Malvy, Hélène Lejoly-Boisseau, Sylvie Daulouède, Denis Thiolat, Sara Coves, Pierrette Courtois, Philippe Vincendeau, M. Djavad Mossalayi

Chemistry; Biosynthesis

  • Chemistry; Biosynthesis
    Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in Streptomyces clavuligerus
    Kapil Tahlan, Hyeon Ung Park, Annie Wong, Perrin H. Beatty, Susan E. Jensen

Letters

  • Letter to the Editor
    Pleural Diffusion of Voriconazole in a Patient with Aspergillus fumigatus Empyema Thoracis
    Jean-Baptiste Stern, Philippe Girard, Raffaele Caliandro
  • LETTERS TO THE EDITOR
    Antibiotic Resistance and Distribution of Tetracycline Resistance Genes in Escherichia coli O157:H7 Isolates from Humans and Bovines
    Chris Wilkerson, Mansour Samadpour, Nicole van Kirk, Marilyn C. Roberts
  • Letter to the Editor
    First Class A Carbapenemase Isolated from Enterobacteriaceae in Argentina
    Marcela Radice, Pablo Power, Gabriel Gutkind, Karina Fernández, Carlos Vay, Angela Famiglietti, Nora Ricover, Juan A. Ayala

Errata

  • Erratum
    Risk Factors for Acquisition of Imipenem-Resistant Acinetobacter baumannii: a Case-Control Study
    Sang-Oh Lee, Nam Joong Kim, Sang-Ho Choi, Tae Hyong Kim, Jin-Won Chung, Jun-Hee Woo, Jiso Ryu, Yang Soo Kim

Author's Correction

  • AUTHOR'S CORRECTION
    A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus
    T. M. Diaz-Guerra, E. Mellado, M. Cuenca-Estrella, J. L. Rodriguez-Tudela
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Antimicrobial Agents and Chemotherapy: 48 (3)

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volume 48, issue 3
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