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Mechanisms of Resistance

Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC β-Lactamase of a Serratia marcescens Clinical Isolate

Hedi Mammeri, Laurent Poirel, Pascal Bemer, Henri Drugeon, Patrice Nordmann
Hedi Mammeri
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 Le Kremlin-Bicêtre
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Laurent Poirel
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 Le Kremlin-Bicêtre
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Pascal Bemer
2Department of Microbiology, Hôtel-Dieu University Hospital, Nantes, France
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Henri Drugeon
2Department of Microbiology, Hôtel-Dieu University Hospital, Nantes, France
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Patrice Nordmann
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 Le Kremlin-Bicêtre
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  • For correspondence: nordmann.patrice@bct.ap-hop-paris.fr
DOI: 10.1128/AAC.48.3.716-720.2004
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Article Information

DOI 
https://doi.org/10.1128/AAC.48.3.716-720.2004
PubMed 
14982755

Published By 
American Society for Microbiology Journals
History 
  • Received July 31, 2003
  • Returned for modification September 26, 2003
  • Accepted November 14, 2003
  • Published online February 24, 2004.

Copyright & Usage 
Copyright © 2004 American Society for Microbiology

Author Information

  1. Hedi Mammeri1,
  2. Laurent Poirel1,
  3. Pascal Bemer2,
  4. Henri Drugeon2 and
  5. Patrice Nordmann1*
  1. 1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 Le Kremlin-Bicêtre
  2. 2Department of Microbiology, Hôtel-Dieu University Hospital, Nantes, France
  • ↵* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr .
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Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC β-Lactamase of a Serratia marcescens Clinical Isolate
Hedi Mammeri, Laurent Poirel, Pascal Bemer, Henri Drugeon, Patrice Nordmann
Antimicrobial Agents and Chemotherapy Feb 2004, 48 (3) 716-720; DOI: 10.1128/AAC.48.3.716-720.2004

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Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC β-Lactamase of a Serratia marcescens Clinical Isolate
Hedi Mammeri, Laurent Poirel, Pascal Bemer, Henri Drugeon, Patrice Nordmann
Antimicrobial Agents and Chemotherapy Feb 2004, 48 (3) 716-720; DOI: 10.1128/AAC.48.3.716-720.2004
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KEYWORDS

Bacterial Proteins
cephalosporins
Chromosomes, Bacterial
mutation
Sequence Deletion
Serratia Infections
Serratia marcescens
beta-lactamases

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