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Mechanisms of Resistance

Mechanism of Increased Fluconazole Resistance in Candida glabrata during Prophylaxis

John E. Bennett, Koichi Izumikawa, Kieren A. Marr
John E. Bennett
1Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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  • For correspondence: jbennett@niaid.nih.gov
Koichi Izumikawa
1Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Kieren A. Marr
2Fred Hutchinson Cancer Research Center, University of Washington, School of Medicine, Seattle, Washington
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DOI: 10.1128/AAC.48.5.1773-1777.2004
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Figures

  • FIG. 1.
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    FIG. 1.

    CHEF gel showing representatives of 16 karyotypes (I to XVI), distinguished at 90% identity.

  • FIG. 2.
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    FIG. 2.

    Fluconazole MICs during fluconazole prophylaxis of 20 patients. Each line represents a single patient. The dashed line is the best-fit line. mcg, micrograms

  • FIG. 3.
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    FIG. 3.

    Rhodamine 6G accumulation in 14 pairs of isolates as a function of fluconazole MIC. Two lines overlap and appear as one line. The dashed line represents the same patient as the dashed line in Fig. 4. mcg, micrograms.

  • FIG. 4.
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    FIG. 4.

    Fluconazole accumulation in 14 pairs of isolates as a function of fluconazole MIC. The dashed line represents the same patient as the dashed line in Fig. 3.

  • FIG. 5.
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    FIG. 5.

    Abundance of PDH1 transcript divided by that of ACT1 transcript in paired susceptible and resistant isolates from 14 patients.

  • FIG. 6.
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    FIG. 6.

    Abundance of CgCDR1 transcript divided by that of ACT1 transcript in paired susceptible and resistant isolates from 14 patients.

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Mechanism of Increased Fluconazole Resistance in Candida glabrata during Prophylaxis
John E. Bennett, Koichi Izumikawa, Kieren A. Marr
Antimicrobial Agents and Chemotherapy Apr 2004, 48 (5) 1773-1777; DOI: 10.1128/AAC.48.5.1773-1777.2004

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Mechanism of Increased Fluconazole Resistance in Candida glabrata during Prophylaxis
John E. Bennett, Koichi Izumikawa, Kieren A. Marr
Antimicrobial Agents and Chemotherapy Apr 2004, 48 (5) 1773-1777; DOI: 10.1128/AAC.48.5.1773-1777.2004
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KEYWORDS

antifungal agents
Candida glabrata
candidiasis
fluconazole

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