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Table of Contents

June 1, 2004; Volume 48,Issue 6

Minireviews

  • Minireview
    Recommendations for Treatment of Human Infections Caused by Bartonella Species
    J. M. Rolain, P. Brouqui, J. E. Koehler, C. Maguina, M. J. Dolan, D. Raoult

Clinical Therapeutics

  • Clinical Therapeutics
    The Magnitude of the Association between Fluoroquinolone Use and Quinolone-Resistant Escherichia coli and Klebsiella pneumoniae May Be Lower than Previously Reported
    Maureen K. Bolon, Sharon B. Wright, Howard S. Gold, Yehuda Carmeli
  • Clinical Therapeutics
    Phase 2, Randomized, Dose-Ranging Study Evaluating the Safety and Efficacy of Anidulafungin in Invasive Candidiasis and Candidemia
    David S. Krause, John Reinhardt, Jose A. Vazquez, Annette Reboli, Beth P. Goldstein, Michele Wible, Timothy Henkel
  • Clinical Therapeutics
    Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration
    Thomas J. Walsh, Mats O. Karlsson, Timothy Driscoll, Adriano G. Arguedas, Peter Adamson, Xavier Saez-Llorens, Ajay J. Vora, Antonio C. Arrieta, Jeffrey Blumer, Irja Lutsar, Peter Milligan, Nolan Wood
  • Clinical Therapeutics
    Short- and Long-Term Effects of Pneumococcal Conjugate Vaccination of Children on Penicillin Resistance
    L. Temime, D. Guillemot, P. Y. Boëlle

Experimental Therapeutics

  • Experimental Therapeutics
    Determination of the In Vivo Pharmacodynamic Profile of Cefepime against Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli at Various Inocula
    Dana Maglio, Christine Ong, Mary Anne Banevicius, Qiuming Geng, Charles H. Nightingale, David P. Nicolau
  • Experimental Therapeutics
    Effectiveness of Ciprofloxacin, Levofloxacin, or Moxifloxacin for Treatment of Experimental Staphylococcus aureus Keratitis
    Joseph J. Dajcs, Brett A. Thibodeaux, Mary E. Marquart, Dalia O. Girgis, Mullika Traidej, Richard J. O'Callaghan
  • Experimental Therapeutics
    Comparative Activities of the Triterpene Saponin Maesabalide III and Liposomal Amphotericin B (AmBisome) against Leishmania donovani in Hamsters
    Louis Maes, Nils Germonprez, Ludo Quirijnen, Luc Van Puyvelde, Paul Cos, Dirk Vanden Berghe
  • Experimental Therapeutics
    Novel Pharmacokinetic-Pharmacodynamic Model for Prediction of Outcomes with an Extended-Release Formulation of Ciprofloxacin
    Alison K. Meagher, Alan Forrest, Axel Dalhoff, Heino Stass, Jerome J. Schentag
  • Experimental Therapeutics
    Efficacies of Amphotericin B (AMB) Lipid Complex, AMB Colloidal Dispersion, Liposomal AMB, and Conventional AMB in Treatment of Murine Coccidioidomycosis
    Gloria M. González, Rolando Tijerina, Laura K. Najvar, Rosie Bocanegra, Michael G. Rinaldi, John R. Graybill
  • Experimental Therapeutics
    Efficacy of Oral Ramoplanin for Inhibition of Intestinal Colonization by Vancomycin-Resistant Enterococci in Mice
    Usha Stiefel, Nicole J. Pultz, Marion S. Helfand, Curtis J. Donskey
  • Experimental Therapeutics
    Effects of Growth Phase and Extracellular Slime on Photodynamic Inactivation of Gram-Positive Pathogenic Bacteria
    Faten Gad, Touqir Zahra, Tayyaba Hasan, Michael R. Hamblin
  • Experimental Therapeutics
    Noninvasive Optical Imaging Method To Evaluate Postantibiotic Effects on Biofilm Infection In Vivo
    Jagath L. Kadurugamuwa, Lin V. Sin, Jun Yu, Kevin P. Francis, Tony F. Purchio, Pamela R. Contag
  • Experimental Therapeutics
    Posaconazole Therapy of Disseminated Phaeohyphomycosis in a Murine Model
    John R. Graybill, Laura K. Najvar, Elizabeth Johnson, Rosie Bocanegra, David Loebenberg

Mechanisms of Resistance

  • Mechanisms of Resistance
    tcaA Inactivation Increases Glycopeptide Resistance in Staphylococcus aureus
    Hideki Maki, Nadine McCallum, Markus Bischoff, Akihito Wada, Brigitte Berger-Bächi
  • Mechanisms of Resistance
    Nosocomial Spread of Ceftazidime-Resistant Klebsiella pneumoniae Strains Producing a Novel Class A β-Lactamase, GES-3, in a Neonatal Intensive Care Unit in Japan
    Jun-ichi Wachino, Yohei Doi, Kunikazu Yamane, Naohiro Shibata, Tetsuya Yagi, Takako Kubota, Hideo Ito, Yoshichika Arakawa
  • Mechanisms of Resistance
    Tn2009, a Tn916-Like Element Containing mef(E) in Streptococcus pneumoniae
    Maria Del Grosso, Anna Scotto d'Abusco, Francesco Iannelli, Gianni Pozzi, Annalisa Pantosti
  • Mechanisms of Resistance
    Biochemical Characterization of the Naturally Occurring Oxacillinase OXA-50 of Pseudomonas aeruginosa
    Delphine Girlich, Thierry Naas, Patrice Nordmann
  • Mechanisms of Resistance
    Genetic Environments of the rmtA Gene in Pseudomonas aeruginosa Clinical Isolates
    Kunikazu Yamane, Yohei Doi, Keiko Yokoyama, Tetsuya Yagi, Hiroshi Kurokawa, Naohiro Shibata, Keigo Shibayama, Haru Kato, Yoshichika Arakawa
  • Mechanisms of Resistance
    Spread of Novel Aminoglycoside Resistance Gene aac(6′)-Iad among Acinetobacter Clinical Isolates in Japan
    Yohei Doi, Jun-ichi Wachino, Kunikazu Yamane, Naohiro Shibata, Tetsuya Yagi, Keigo Shibayama, Haru Kato, Yoshichika Arakawa
  • Mechanisms of Resistance
    Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae
    Katherine A. Gould, Xiao-Su Pan, Robert J. Kerns, L. Mark Fisher
  • Mechanisms of Resistance
    Evolution of Resistance to Sulfadoxine-Pyrimethamine in Plasmodium falciparum
    Michelle L. Gatton, Laura B Martin, Qin Cheng
  • Mechanisms of Resistance
    Application of Real-Time Quantitative PCR to Molecular Analysis of Candida albicans Strains Exhibiting Reduced Susceptibility to Azoles
    Andrew S. Chau, Cara A. Mendrick, Frank J. Sabatelli, David Loebenberg, Paul M. McNicholas
  • Mechanisms of Resistance
    Omp35, a New Enterobacter aerogenes Porin Involved in Selective Susceptibility to Cephalosporins
    Charléric Bornet, Nathalie Saint, Lilia Fetnaci, Myrielle Dupont, Anne Davin-Régli, Claude Bollet, Jean-Marie Pagès
  • Mechanisms of Resistance
    Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936)
    Takahiro Hirata, Asami Saito, Kunihiko Nishino, Norihisa Tamura, Akihito Yamaguchi
  • Mechanisms of Resistance
    Sulfadoxine Resistance in Plasmodium vivax Is Associated with a Specific Amino Acid in Dihydropteroate Synthase at the Putative Sulfadoxine-Binding Site
    Michael Korsinczky, Katja Fischer, Nanhua Chen, Joanne Baker, Karl Rieckmann, Qin Cheng
  • Mechanisms of Resistance
    Clade-Specific Flucytosine Resistance Is Due to a Single Nucleotide Change in the FUR1 Gene of Candida albicans
    Andrew R. Dodgson, Kirsty J. Dodgson, Claude Pujol, Michael A. Pfaller, David R. Soll
  • Mechanisms of Resistance
    Complete Sequences of Six Penicillin-Binding Protein Genes from 40 Streptococcus pneumoniae Clinical Isolates Collected in Japan
    Yumiko Sanbongi, Takashi Ida, Midori Ishikawa, Yumi Osaki, Hiroshi Kataoka, Takahisa Suzuki, Kumiko Kondo, Fukuichi Ohsawa, Minoru Yonezawa
  • Mechanisms of Resistance
    Regulatory Regions of smeDEF in Stenotrophomonas maltophilia Strains Expressing Different Amounts of the Multidrug Efflux Pump SmeDEF
    Patricia Sanchez, Ana Alonso, Jose L. Martinez
  • Mechanisms of Resistance
    Nosocomial Outbreak of Extended-Spectrum β-Lactamase SHV-5-Producing Isolates of Pseudomonas aeruginosa in Athens, Greece
    Laurent Poirel, Evangelia Lebessi, Marisa Castro, Cindy Fèvre, Maria Foustoukou, Patrice Nordmann
  • Mechanisms of Resistance
    Salmonella Gene rma (ramA) and Multiple-Drug-Resistant Salmonella enterica Serovar Typhimurium
    Tahar van der Straaten, Riny Janssen, Dik J. Mevius, Jaap T. van Dissel
  • Mechanisms of Resistance
    Fitness Cost of SCCmec and Methicillin Resistance Levels in Staphylococcus aureus
    Miriam Ender, Nadine McCallum, Rajan Adhikari, Brigitte Berger-Bächi
  • Mechanisms of Resistance
    Genetic Basis of Erythromycin Resistance in Oral Bacteria
    A. Villedieu, M. L. Diaz-Torres, A. P. Roberts, N. Hunt, R. McNab, D. A. Spratt, M. Wilson, P. Mullany
  • Mechanisms of Resistance
    High-Level Resistance to Ceftazidime Conferred by a Novel Enzyme, CTX-M-32, Derived from CTX-M-1 through a Single Asp240-Gly Substitution
    Monica Cartelle, Maria del Mar Tomas, Francisca Molina, Rita Moure, Rosa Villanueva, German Bou
  • Mechanisms of Resistance
    Molecular Characterization of a Carbapenem-Hydrolyzing Class A β-Lactamase, SFC-1, from Serratia fonticola UTAD54
    Isabel Henriques, Alexandra Moura, Artur Alves, Maria José Saavedra, António Correia
  • Mechanisms of Resistance
    IMP-1 and a Novel Metallo-β-Lactamase, VIM-6, in Fluorescent Pseudomonads Isolated in Singapore
    Tse Hsien Koh, Grace Chee Yeng Wang, Li-Hwei Sng

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells
    Andrea Sudano Roccaro, Anna Rita Blanco, Francesco Giuliano, Dario Rusciano, Vincenzo Enea
  • Mechanisms of Action: Physiological Effects
    Anti-Inflammatory Effects of Moxifloxacin on Activated Human Monocytic Cells: Inhibition of NF-κB and Mitogen-Activated Protein Kinase Activation and of Synthesis of Proinflammatory Cytokines
    Taly Weiss, Itamar Shalit, Hannah Blau, Sara Werber, Drora Halperin, Avital Levitov, Ina Fabian
  • Mechanisms of Action: Physiological Effects
    The Action of Bismuth against Helicobacter pylori Mimics but Is Not Caused by Intracellular Iron Deprivation
    Michael V. Bland, Salim Ismail, Jack A. Heinemann, Jacqueline I. Keenan
  • Mechanisms of Action: Physiological Effects
    Reactivity of Platelia Aspergillus Galactomannan Antigen with Piperacillin-Tazobactam: Clinical Implications Based on Achievable Concentrations in Serum
    Nina Singh, Asia Obman, Shahid Husain, Sherrie Aspinall, Sue Mietzner, Janet E. Stout
  • Mechanisms of Action: Physiological Effects
    Mercury Inactivates Transcription and the Generalized Transcription Factor TFB in the Archaeon Sulfolobus solfataricus
    Vidula Dixit, Elisabetta Bini, Melissa Drozda, Paul Blum
  • Mechanisms of Action: Physiological Effects
    Interaction of Antimycobacterial Drugs with the Anti-Mycobacterium avium Complex Effects of Antimicrobial Effectors, Reactive Oxygen Intermediates, Reactive Nitrogen Intermediates, and Free Fatty Acids Produced by Macrophages
    Keisuke Sano, Haruaki Tomioka, Katsumasa Sato, Chiaki Sano, Hideyuki Kawauchi, Shanshan Cai, Toshiaki Shimizu
  • Mechanisms of Action: Physiological Effects
    Pyruvate Decarboxylase, the Target for Omeprazole in Metronidazole-Resistant and Iron-Restricted Tritrichomonas foetus
    Róbert Sutak, Jan Tachezy, Jaroslav Kulda, Ivan Hrdý
  • Mechanisms of Action: Physiological Effects
    Structure and Association of Human Lactoferrin Peptides with Escherichia coli Lipopolysaccharide
    Daniel S. Chapple, Rohanah Hussain, Christopher L. Joannou, Robert E. W. Hancock, Edward Odell, Robert W. Evans, Giuliano Siligardi
  • Mechanisms of Action: Physiological Effects
    Effect of Erythromycin on Chronic Respiratory Infection Caused by Pseudomonas aeruginosa with Biofilm Formation in an Experimental Murine Model
    Towako Nagata, Hiroshi Mukae, Junichi Kadota, Tomayoshi Hayashi, Takeshi Fujii, Misuzu Kuroki, Ryo Shirai, Katsunori Yanagihara, Kazunori Tomono, Takehiko Koji, Shigeru Kohno
  • Mechanisms of Action: Physiological Effects
    In Vitro Effects of Albendazole Sulfoxide and Praziquantel against Taenia solium and Taenia crassiceps Cysts
    Francisca Palomares, Guadalupe Palencia, Rodolfo Pérez, Dinora González-Esquivel, Nelly Castro, Helgi Jung Cook
  • Mechanisms of Action: Physiological Effects
    Enhanced Production of Farnesol by Candida albicans Treated with Four Azoles
    Jacob M. Hornby, Kenneth W. Nickerson

Susceptibility

  • Susceptibility
    Susceptibility of Candida Species to Photodynamic Effects of Photofrin
    Joseph M. Bliss, Chad E. Bigelow, Thomas H. Foster, Constantine G. Haidaris
  • Susceptibility
    In Vitro Interactions between Amphotericin B, Itraconazole, and Flucytosine against 21 Clinical Aspergillus Isolates Determined by Two Drug Interaction Models
    D. T. A. Te Dorsthorst, P. E. Verweij, J. F. G. M. Meis, N. C. Punt, J. W. Mouton
  • Susceptibility
    Effects of Voriconazole on Cryptococcus neoformans
    David van Duin, Wendy Cleare, Oscar Zaragoza, Arturo Casadevall, Joshua D. Nosanchuk
  • Susceptibility
    Antimicrobial Activities of Garenoxacin (BMS 284756) against Asia-Pacific Region Clinical Isolates from the SENTRY Program, 1999 to 2001
    K. J. Christiansen, J. M. Bell, J. D. Turnidge, R. N. Jones
  • Susceptibility
    In Vitro Activities of Garenoxacin and Levofloxacin against Chlamydia pneumoniae Are Not Affected by Presence of Mycoplasma DNA
    Raymond P. Smith, Aldona L. Baltch, William J. Ritz, Andrea N. Carpenter, Tanya A. Halse, Lawrence H. Bopp
  • Susceptibility
    Antibacterial Activities of the Cathelicidins Prophenin (Residues 62 to 79) and LL-37 in the Presence of a Lung Surfactant Preparation
    Yuqin Wang, Gabi Walter, Egbert Herting, Birgitta Agerberth, Jan Johansson
  • Susceptibility
    High Prevalence of Antimicrobial Resistance among Clinical Streptococcus pneumoniae Isolates in Asia (an ANSORP Study)
    Jae-Hoon Song, Sook-In Jung, Kwan Soo Ko, Na Young Kim, Jun Seong Son, Hyun-Ha Chang, Hyun Kyun Ki, Won Sup Oh, Ji Yoeun Suh, Kyong Ran Peck, Nam Yong Lee, Yonghong Yang, Quan Lu, Anan Chongthaleong, Cheng-Hsun Chiu, M. K. Lalitha, Jennifer Perera, Ti Teow Yee, Gamini Kumarasinghe, Farida Jamal, Adeeba Kamarulzaman, Navaratnam Parasakthi, Pham Hung Van, Celia Carlos, Thomas So, Tak Keung Ng, Atef Shibl
  • Susceptibility
    In Vitro Activities of the New Semisynthetic Glycopeptide Telavancin (TD-6424), Vancomycin, Daptomycin, Linezolid, and Four Comparator Agents against Anaerobic Gram-Positive Species and Corynebacterium spp
    Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, Helen T. Fernandez
  • Susceptibility
    In Vitro Activity of OPT-80 against Clostridium difficile
    Grit Ackermann, Birgit Löffler, Daniela Adler, Arne C. Rodloff

Antiviral Agents

  • Antiviral Agents
    Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread
    Natalia Cheshenko, Marla J. Keller, Veronica MasCasullo, Gary A. Jarvis, Hui Cheng, Minnie John, Jin-Hua Li, Kathleen Hogarty, Robert A. Anderson, Donald P. Waller, Lourens J. D. Zaneveld, Albert T. Profy, Mary E. Klotman, Betsy C. Herold
  • Antiviral Agents
    α-Galactosylceramide and Novel Synthetic Glycolipids Directly Induce the Innate Host Defense Pathway and Have Direct Activity against Hepatitis B and C Viruses
    Anand S. Mehta, Baohua Gu, Bertha Conyers, Serguey Ouzounov, Lijuan Wang, Robert M. Moriarty, Raymond A. Dwek, Timothy M. Block
  • Antiviral Agents
    Mutation D30N Is Not Preferentially Selected by Human Immunodeficiency Virus Type 1 Subtype C in the Development of Resistance to Nelfinavir
    Zehava Grossman, Ellen E. Paxinos, Diana Averbuch, Shlomo Maayan, Neil T. Parkin, Dan Engelhard, Margalit Lorber, Valery Istomin, Yael Shaked, Ella Mendelson, Daniela Ram, Chris J. Petropoulos, Jonathan M. Schapiro
  • Antiviral Agents
    Phosphorothioate Di- and Trinucleotides as a Novel Class of Anti-Hepatitis B Virus Agents
    Radhakrishnan P. Iyer, Yi Jin, Arlene Roland, John D. Morrey, Samir Mounir, Brent Korba
  • Antiviral Agents
    Mechanism of Action at the Molecular Level of the Antiviral Drug 3(2H)-Isoflavene against Type 2 Poliovirus
    Anna L. Salvati, Alessandra De Dominicis, Sabrina Tait, Andrea Canitano, Armin Lahm, Lucia Fiore
  • Antiviral Agents
    Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro
    Liangjun Lu, Tami J. Pilot-Matias, Kent D. Stewart, John T. Randolph, Ron Pithawalla, Wenping He, Peggy P. Huang, Larry L. Klein, Hongmei Mo, Akhteruzzaman Molla
  • Antiviral Agents
    Efficacy of Cidofovir in a Murine Model of Disseminated Progressive Vaccinia
    Johan Neyts, Pieter Leyssen, Erik Verbeken, Erik De Clercq
  • Antiviral Agents
    Immunopharmacology of CpG Oligodeoxynucleotides and Ribavirin
    Jörg Vollmer, Robert Rankin, Hanna Hartmann, Marion Jurk, Ulrike Samulowitz, Tanja Wader, Andrea Janosch, Christian Schetter, Arthur M. Krieg
  • Antiviral Agents
    Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model
    Radhakrishnan P. Iyer, Arlene Roland, Yi Jin, Samir Mounir, Brent Korba, Justin G. Julander, John D. Morrey
  • Antiviral Agents
    Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages
    Gary D. Ewart, Najla Nasr, Hassan Naif, Graeme B. Cox, Anthony L. Cunningham, Peter W. Gage
  • Antiviral Agents
    ELVIRA HSV, a Yield Reduction Assay for Rapid Herpes Simplex Virus Susceptibility Testing
    Růžena Stránská, Rob Schuurman, David R. Scholl, Joseph A. Jollick, Carl J. Shaw, Caroline Loef, Merjo Polman, Anton M. van Loon
  • Antiviral Agents
    Lack of Effect of Recombinant Human Growth Hormone on the In Vitro Activities of Antiretroviral Drugs against Human Immunodeficiency Virus Type 1
    Mark A Wainberg, Bluma G. Brenner, Eric Daar, Joseph M. Gertner, Clement Olivier, Susan Kenley

Pharmacology

  • Pharmacology
    Interactions between Atazanavir-Ritonavir and Tenofovir in Heavily Pretreated Human Immunodeficiency Virus-Infected Patients
    Anne-Marie Taburet, Christophe Piketty, Corine Chazallon, Isabelle Vincent, Laurence Gérard, Vincent Calvez, Francois Clavel, Jean-Pierre Aboulker, Pierre-Marie Girard
    and the ANRS Protocol 107 Puzzle 2 Investigators
  • Pharmacology
    Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis
    Florian Tomaselli, Alfred Maier, Veronika Matzi, Freyja Maria Smolle-Jüttner, Peter Dittrich

Letters

  • Letter to the Editor
    Successful Use of Voriconazole for Treatment of Coccidioides Meningitis
    Laurie A. Proia, Allan R. Tenorio
  • Letter to the Editor
    Aeromonas hydrophila with Plasmid-Borne Class A Extended-Spectrum β-Lactamase TEM-24 and Three Chromosomal Class B, C, and D β-Lactamases, Isolated from a Patient with Necrotizing Fasciitis
    T. Fosse, C. Giraud-Morin, I. Madinier, F. Mantoux, J. P. Lacour, J. P. Ortonne
  • Letter to the Editor
    Emergence of the Extended-Spectrum β-Lactamase GES-1 in a Pseudomonas aeruginosa Strain from Brazil: Report from the SENTRY Antimicrobial Surveillance Program
    Mariana Castanheira, Rodrigo E. Mendes, Timothy R. Walsh, Ana C. Gales, Ronald N. Jones

Errata

  • Erratum
    Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques
    Koen K. A. Van Rompay, Laurie L. Brignolo, Dennis J. Meyer, Christopher Jerome, Ross Tarara, Abigail Spinner, Marta Hamilton, Linda L. Hirst, David R. Bennett, Don R. Canfield, Trish G. Dearman, Wilhelm Von Morgenland, Phil C. Allen, Celia Valverde, Alesha B. Castillo, R. Bruce Martin, Valerie F. Samii, Ray Bendele, John Desjardins, Marta L. Marthas, Niels C. Pedersen, Norbert Bischofberger
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Antimicrobial Agents and Chemotherapy: 48 (6)

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volume 48, issue 6
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  • Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2
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