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Clinical Therapeutics

Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration

Thomas J. Walsh, Mats O. Karlsson, Timothy Driscoll, Adriano G. Arguedas, Peter Adamson, Xavier Saez-Llorens, Ajay J. Vora, Antonio C. Arrieta, Jeffrey Blumer, Irja Lutsar, Peter Milligan, Nolan Wood
Thomas J. Walsh
1National Cancer Institute and
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  • For correspondence: walsht@mail.nih.gov
Mats O. Karlsson
2Bethesda, Maryland; Uppsala University, Uppsala, Sweden
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Timothy Driscoll
3Duke University Medical Center, Durham, North Carolina
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Adriano G. Arguedas
4Instituto Costarricense de Invetigaciones Clinicas and National Children's Hospital, San Jose, Costa Rica
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Peter Adamson
5Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
6Pediatric Pharmacology Unit, National Institute of Child Health and Human Development
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Xavier Saez-Llorens
7Hospital del Niños, Ciudad de Panama, Panama
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Ajay J. Vora
8Sheffield Children's Hospital, Sheffield
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Antonio C. Arrieta
9Children's Hospital of Orange County, Orange, California
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Jeffrey Blumer
6Pediatric Pharmacology Unit, National Institute of Child Health and Human Development
10University Hospitals of Cleveland, Cleveland, Ohio
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Irja Lutsar
11Pfizer Global Research and Development, Sandwich, Kent, United Kingdom
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Peter Milligan
11Pfizer Global Research and Development, Sandwich, Kent, United Kingdom
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Nolan Wood
11Pfizer Global Research and Development, Sandwich, Kent, United Kingdom
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DOI: 10.1128/AAC.48.6.2166-2172.2004
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Article Information

DOI 
https://doi.org/10.1128/AAC.48.6.2166-2172.2004
PubMed 
15155217

Published By 
American Society for Microbiology Journals
History 
  • Received November 3, 2003
  • Returned for modification December 12, 2003
  • Accepted February 4, 2004
  • Published online May 21, 2004.

Copyright & Usage 
Copyright © 2004 American Society for Microbiology

Author Information

  1. Thomas J. Walsh1*,
  2. Mats O. Karlsson2,
  3. Timothy Driscoll3,
  4. Adriano G. Arguedas4,
  5. Peter Adamson5,6,
  6. Xavier Saez-Llorens7,
  7. Ajay J. Vora8,
  8. Antonio C. Arrieta9,
  9. Jeffrey Blumer6,10,
  10. Irja Lutsar11,
  11. Peter Milligan11 and
  12. Nolan Wood11
  1. 1National Cancer Institute and
  2. 6Pediatric Pharmacology Unit, National Institute of Child Health and Human Development
  3. 2Bethesda, Maryland; Uppsala University, Uppsala, Sweden
  4. 3Duke University Medical Center, Durham, North Carolina
  5. 4Instituto Costarricense de Invetigaciones Clinicas and National Children's Hospital, San Jose, Costa Rica
  6. 5Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  7. 7Hospital del Niños, Ciudad de Panama, Panama
  8. 8Sheffield Children's Hospital, Sheffield
  9. 11Pfizer Global Research and Development, Sandwich, Kent, United Kingdom
  10. 9Children's Hospital of Orange County, Orange, California
  11. 10University Hospitals of Cleveland, Cleveland, Ohio
  • ↵* Corresponding author. Mailing address: Pediatric Oncology Branch, National Cancer Institute, Bldg. 10, Rm. 13N240, Bethesda, MD 20892. Phone: (301) 496-7103. Fax: (301) 402-0575. E-mail: walsht{at}mail.nih.gov .
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Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration
Thomas J. Walsh, Mats O. Karlsson, Timothy Driscoll, Adriano G. Arguedas, Peter Adamson, Xavier Saez-Llorens, Ajay J. Vora, Antonio C. Arrieta, Jeffrey Blumer, Irja Lutsar, Peter Milligan, Nolan Wood
Antimicrobial Agents and Chemotherapy May 2004, 48 (6) 2166-2172; DOI: 10.1128/AAC.48.6.2166-2172.2004

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Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration
Thomas J. Walsh, Mats O. Karlsson, Timothy Driscoll, Adriano G. Arguedas, Peter Adamson, Xavier Saez-Llorens, Ajay J. Vora, Antonio C. Arrieta, Jeffrey Blumer, Irja Lutsar, Peter Milligan, Nolan Wood
Antimicrobial Agents and Chemotherapy May 2004, 48 (6) 2166-2172; DOI: 10.1128/AAC.48.6.2166-2172.2004
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KEYWORDS

antifungal agents
Pyrimidines
triazoles

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