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Table of Contents

July 1, 2004; Volume 48,Issue 7

Guest Commentary

  • GUEST COMMENTARY
    Update of the Standard Numbering Scheme for Class B β-Lactamases
    Gianpiero Garau, Isabel García-Sáez, Carine Bebrone, Christine Anne, Paola Mercuri, Moreno Galleni, Jean-Marie Frère, Otto Dideberg

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Defined Anaerobic Growth Medium for Studying Candida albicans Basic Biology and Resistance to Eight Antifungal Drugs
    Raluca Dumitru, Jacob M. Hornby, Kenneth W. Nickerson
  • Mechanisms of Action: Physiological Effects
    Antimalarial Quinolines and Artemisinin Inhibit Endocytosis in Plasmodium falciparum
    Heinrich C. Hoppe, Donelly A. van Schalkwyk, Ursula I. M. Wiehart, Sandra A. Meredith, Joanne Egan, Brandon W. Weber
  • Mechanisms of Action: Physiological Effects
    Inhibition of Mycobacterium tuberculosis AhpD, an Element of the Peroxiredoxin Defense against Oxidative Stress
    Aleksey Koshkin, Xiao-ti Zhou, Carl N. Kraus, Jason M. Brenner, Pradipta Bandyopadhyay, Irwin D. Kuntz, Clifton E. Barry, Paul R. Ortiz de Montellano
  • Mechanisms of Action: Physiological Effects
    Candida glabrata erg1 Mutant with Increased Sensitivity to Azoles and to Low Oxygen Tension
    Huei-Fung Tsai, Martin Bard, Koichi Izumikawa, Anna A. Krol, Aaron M. Sturm, Nicholas T. Culbertson, Charles A. Pierson, John E. Bennett
  • Mechanisms of Action: Physiological Effects
    Terpenes Arrest Parasite Development and Inhibit Biosynthesis of Isoprenoids in Plasmodium falciparum
    Herbert Rodrigues Goulart, Emília A. Kimura, Valnice J. Peres, Alicia S. Couto, Fulgencio A. Aquino Duarte, Alejandro M. Katzin
  • Mechanisms of Action: Physiological Effects
    Panel of Bacillus subtilis Reporter Strains Indicative of Various Modes of Action
    Bernd Hutter, Christina Fischer, Alexander Jacobi, Christoph Schaab, Hannes Loferer
  • Mechanisms of Action: Physiological Effects
    The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains
    Geoffrey S. Dow, Michael L. Koenig, Lesley Wolf, Lucia Gerena, Miriam Lopez-Sanchez, Thomas H. Hudson, Apurba K. Bhattacharjee
  • Mechanisms of Action: Physiological Effects
    Enzymatic Detachment of Staphylococcus epidermidis Biofilms
    Jeffrey B. Kaplan, Chandran Ragunath, Kabilan Velliyagounder, Daniel H. Fine, Narayanan Ramasubbu
  • Mechanisms of Action: Physiological Effects
    Constitutive Activation of the PDR16 Promoter in a Candida albicans Azole-Resistant Clinical Isolate Overexpressing CDR1 and CDR2
    Xavier De Deken, Martine Raymond
  • Mechanisms of Action: Physiological Effects
    Lysostaphin-Coated Catheters Eradicate Staphylococccus aureus Challenge and Block Surface Colonization
    Anjali Shah, James Mond, Scott Walsh
  • Mechanisms of Action: Physiological Effects
    Micafungin Enhances Neutrophil Fungicidal Functions against Candida Pseudohyphae
    Cristina Gil-Lamaignere, Stefanie Salvenmoser, Regina Hess, Frank-Michael C. Müller
  • Mechanisms of Action: Physiological Effects
    Enhancement of the Enterocin CRL35 Activity by a Synthetic Peptide Derived from the NH2-Terminal Sequence
    Lucila Saavedra, Carlos Minahk, Aída P. de Ruiz Holgado, Fernando Sesma

Mechanisms of Resistance

  • Mechanisms of Resistance
    Single-Nucleotide Polymorphism Mutation Spectra and Resistance to Quinolones in Salmonella enterica Serovar Enteritidis with a Mutator Phenotype
    Dan D. Levy, Bhavana Sharma, Thomas A. Cebula
  • Mechanisms of Resistance
    Antibiotic Resistance Conferred by a Class I Integron and SXT Constin in Vibrio cholerae O1 Strains Isolated in Laos
    Masaaki Iwanaga, Claudia Toma, Tomoko Miyazato, Sithat Insisiengmay, Noboru Nakasone, Masahiko Ehara
  • Mechanisms of Resistance
    Diversity and Evolution of the Class A Chromosomal Beta-Lactamase Gene in Klebsiella pneumoniae
    S. Hæggman, S. Löfdahl, A. Paauw, J. Verhoef, S. Brisse
  • Mechanisms of Resistance
    Cloning of S-Adenosyl-l-Methionine:C-24-Δ-Sterol-Methyltransferase (ERG6) from Leishmania donovani and Characterization of mRNAs in Wild-Type and Amphotericin B-Resistant Promastigotes
    Mohammad Pourshafie, Stanislas Morand, Alain Virion, Michaelle Rakotomanga, Corinne Dupuy, Philippe M. Loiseau
  • Mechanisms of Resistance
    Efflux Pump-Mediated Intrinsic Drug Resistance in Mycobacterium smegmatis
    Xian-Zhi Li, Li Zhang, Hiroshi Nikaido
  • Mechanisms of Resistance
    Extra Copies of the Aspergillus fumigatus Squalene Epoxidase Gene Confer Resistance to Terbinafine: Genetic Approach to Studying Gene Dose-Dependent Resistance to Antifungals in A. fumigatus
    Wei Liu, Gregory S. May, Michail S. Lionakis, Russell E. Lewis, Dimitrios P. Kontoyiannis
  • Mechanisms of Resistance
    Salmonella Genomic Island 1 Multidrug Resistance Gene Clusters in Salmonella enterica Serovar Agona Isolated in Belgium in 1992 to 2002
    Benoît Doublet, Patrick Butaye, Hein Imberechts, David Boyd, Michael R. Mulvey, Elisabeth Chaslus-Dancla, Axel Cloeckaert
  • Mechanisms of Resistance
    RamA Is an Alternate Activator of the Multidrug Resistance Cascade in Enterobacter aerogenes
    Renaud Chollet, Jacqueline Chevalier, Claude Bollet, Jean-Marie Pages, Anne Davin-Regli
  • Mechanisms of Resistance
    Molecular Characterization of Benzimidazole Resistance in Helicobacter pylori
    Scott D. Mills, Wei Yang, Kathleen MacCormack
  • Mechanisms of Resistance
    Saccharomyces cerevisiae Multidrug Transporter Qdr2p (Yil121wp): Localization and Function as a Quinidine Resistance Determinant
    Rita C. Vargas, Sandra Tenreiro, Miguel C. Teixeira, Alexandra R. Fernandes, Isabel Sá-Correia
  • Mechanisms of Resistance
    Pneumocystis jiroveci Dihydropteroate Synthase Polymorphisms Confer Resistance to Sulfadoxine and Sulfanilamide in Saccharomyces cerevisiae
    I. Meneau, D. Sanglard, J. Bille, P. M. Hauser
  • Mechanisms of Resistance
    Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model
    Peter Iliades, Steven R. Meshnick, Ian G. Macreadie
  • Mechanisms of Resistance
    Novel Type V Staphylococcal Cassette Chromosome mec Driven by a Novel Cassette Chromosome Recombinase, ccrC
    Teruyo Ito, Xiao Xue Ma, Fumihiko Takeuchi, Keiko Okuma, Harumi Yuzawa, Keiichi Hiramatsu
  • Mechanisms of Resistance
    Inhibitor-Sensitive AmpC β-Lactamase Variant Produced by an Escherichia coli Clinical Isolate Resistant to Oxyiminocephalosporins and Cephamycins
    Yohei Doi, Jun-ichi Wachino, Masaji Ishiguro, Hiroshi Kurokawa, Kunikazu Yamane, Naohiro Shibata, Keigo Shibayama, Keiko Yokoyama, Haru Kato, Tetsuya Yagi, Yoshichika Arakawa
  • Mechanisms of Resistance
    Oxygen Limitation Contributes to Antibiotic Tolerance of Pseudomonas aeruginosa in Biofilms
    Giorgia Borriello, Erin Werner, Frank Roe, Aana M. Kim, Garth D. Ehrlich, Philip S. Stewart
  • Mechanisms of Resistance
    Purification and Characterization of Recombinant Staphylococcus haemolyticus DNA Gyrase and Topoisomerase IV Expressed in Escherichia coli
    Joel C. Bronstein, Stacey L. Olson, Kristin LeVier, Mark Tomilo, Peter C. Weber
  • Mechanisms of Resistance
    Incidence of the Recently Described Sulfonamide Resistance Gene sul3 among German Salmonella enterica Strains Isolated from Livestock and Food
    Beatriz Guerra, Ernst Junker, Reiner Helmuth
  • Mechanisms of Resistance
    Antimicrobial Susceptibility Patterns and Macrolide Resistance Genes of β-Hemolytic Streptococci in Korea
    Young Uh, In Ho Jang, Gyu Yel Hwang, Mi Kyung Lee, Kap Jun Yoon, Hyo Youl Kim
  • Mechanisms of Resistance
    Proteomic Analysis of Azole Resistance in Candida albicans Clinical Isolates
    Massoumeh Z. Hooshdaran, Katherine S. Barker, George M. Hilliard, Harald Kusch, Joachim Morschhäuser, P. David Rogers
  • Mechanisms of Resistance
    pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis Isolates in Portugal
    Isabel Portugal, Luís Barreiro, José Moniz-Pereira, Laura Brum
  • Mechanisms of Resistance
    Substitutions at Methionine 220 in the 14α-Sterol Demethylase (Cyp51A) of Aspergillus fumigatus Are Responsible for Resistance In Vitro to Azole Antifungal Drugs
    E. Mellado, G. Garcia-Effron, L. Alcazar-Fuoli, M. Cuenca-Estrella, J. L. Rodriguez-Tudela
  • Mechanisms of Resistance
    rpoB Mutations in Streptococcus mitis Clinical Isolates Resistant to Rifampin
    Wafa Achour, Olfa Guenni, Marguerite Fines, Roland Leclercq, Assia Ben Hassen

Experimental Therapeutics

  • Experimental Therapeutics
    In Vitro and In Vivo Activities of E5700 and ER-119884, Two Novel Orally Active Squalene Synthase Inhibitors, against Trypanosoma cruzi
    Julio A. Urbina, Juan Luis Concepcion, Aura Caldera, Gilberto Payares, Cristina Sanoja, Takeshi Otomo, Hironobu Hiyoshi
  • Experimental Therapeutics
    A Small Peptide (CEL-1000) Derived from the β-Chain of the Human Major Histocompatibility Complex Class II Molecule Induces Complete Protection against Malaria in an Antigen-Independent Manner
    Yupin Charoenvit, Gary T. Brice, David Bacon, Victoria Majam, Jackie Williams, Esteban Abot, Harini Ganeshan, Martha Sedegah, Denise L. Doolan, Daniel J. Carucci, Daniel H. Zimmerman
  • Experimental Therapeutics
    A Chimeric Peptide Composed of a Dermaseptin Derivative and an RNA III-Inhibiting Peptide Prevents Graft-Associated Infections by Antibiotic-Resistant Staphylococci
    Naomi Balaban, Yael Gov, Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Fiorenza Orlando, Giuseppina D'Amato, Vittorio Saba, Giorgio Scalise, Sabina Bernes, Amram Mor
  • Experimental Therapeutics
    Beneficial Influence of Platelets on Antibiotic Efficacy in an In Vitro Model of Staphylococcus aureus-Induced Endocarditis
    Renee-Claude Mercier, Robert M. Dietz, Jory L. Mazzola, Arnold S. Bayer, Michael R. Yeaman
  • Experimental Therapeutics
    In Vitro and In Vivo Bacteriolytic Activities of Escherichia coli Phages: Implications for Phage Therapy
    Sandra Chibani-Chennoufi, Josette Sidoti, Anne Bruttin, Elizabeth Kutter, Shafiq Sarker, Harald Brüssow
  • Experimental Therapeutics
    Sustained-Release Formulation of Doxycycline Hyclate for Prophylaxis of Tick Bite Infection in a Murine Model of Lyme Borreliosis
    N. S. Zeidner, K. S. Brandt, E. Dadey, M. C. Dolan, C. Happ, J. Piesman

Antiviral Agents

  • Antiviral Agents
    Intracellular and Plasma Pharmacokinetics of Saquinavir-Ritonavir, Administered at 1,600/100 Milligrams Once Daily in Human Immunodeficiency Virus-Infected Patients
    Jennifer Ford, Marta Boffito, Adrian Wildfire, Andrew Hill, David Back, Saye Khoo, Mark Nelson, Graeme Moyle, Brian Gazzard, Anton Pozniak
  • Antiviral Agents
    Model System for High-Throughput Screening of Novel Human Immunodeficiency Virus Protease Inhibitors in Escherichia coli
    Ting-Jen Cheng, Ashraf Brik, Chi-Huey Wong, Chen-Chen Kan
  • Antiviral Agents
    Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection
    Christopher Cianci, Eugene V. Genovesi, Lucinda Lamb, Ivette Medina, Zheng Yang, Lisa Zadjura, Hyekyung Yang, Celia D'Arienzo, Ny Sin, Kuo-Long Yu, Keith Combrink, Zhufang Li, Richard Colonno, Nicholas Meanwell, Junius Clark, Mark Krystal
  • Antiviral Agents
    Efficacy of Organic Acids in Hand Cleansers for Prevention of Rhinovirus Infections
    Ronald B. Turner, Kim A. Biedermann, Jeffery M. Morgan, Bruce Keswick, Keith D. Ertel, Mark F. Barker
  • Antiviral Agents
    Effect of a Combination of Clevudine and Emtricitabine with Adenovirus-Mediated Delivery of Gamma Interferon in the Woodchuck Model of Hepatitis B Virus Infection
    A. C. Jacquard, M. Nassal, C. Pichoud, S. Ren, U. Schultz, S. Guerret, M. Chevallier, B. Werle, S. Peyrol, C. Jamard, L. T. Rimsky, C. Trepo, F. Zoulim
  • Antiviral Agents
    Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide
    Chang-Jer Wu, Jia-Tsrong Jan, Chi-Min Chen, Hsing-Pang Hsieh, Der-Ren Hwang, Hwan-Wun Liu, Chiu-Yi Liu, Hui-Wen Huang, Su-Chin Chen, Cheng-Fong Hong, Ren-Kuo Lin, Yu-Sheng Chao, John T. A. Hsu
  • Antiviral Agents
    Rhesus Cytomegalovirus Is Similar to Human Cytomegalovirus in Susceptibility to Βenzimidazole Nucleosides
    Thomas W. North, Getachew Sequar, Leroy B. Townsend, John C. Drach, Peter A. Barry

Pharmacology

  • Pharmacology
    Randomized Comparison of Serum Teicoplanin Concentrations following Daily or Alternate Daily Dosing in Healthy Adults
    Bernard Rouveix, François Jehl, Henri Drugeon, Ivan Brumpt, Evelyne Caulin
  • Pharmacology
    Single-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers
    Anne Schmitt-Hoffmann, Brigitte Roos, Michael Schleimer, Jill Sauer, Anthony Man, Norman Nashed, Thomas Brown, Antonio Perez, Erhard Weidekamm, Péter Kovács
  • Pharmacology
    Multiple-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers
    Anne Schmitt-Hoffmann, Lars Nyman, Brigitte Roos, Michael Schleimer, Jill Sauer, Norman Nashed, Thomas Brown, Anthony Man, Erhard Weidekamm
  • Pharmacology
    Absorption of Ester Prodrugs in Caco-2 and Rat Intestine Models
    Xin He, Mitsuru Sugawara, Yoh Takekuma, Katsumi Miyazaki
  • Pharmacology
    Active Efflux of Ciprofloxacin from J774 Macrophages through an MRP-Like Transporter
    Jean-Michel Michot, Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens

Susceptibility

  • Susceptibility
    Factors Associated with Relative Rates of Antibiotic Resistance in Pseudomonas aeruginosa Isolates Tested in Clinical Laboratories in the United States from 1999 to 2002
    Robert K. Flamm, Mellany K. Weaver, Clyde Thornsberry, Mark E. Jones, James A. Karlowsky, Daniel F. Sahm
  • Susceptibility
    Patterns of Amphotericin B Killing Kinetics against Seven Candida Species
    Emilia Cantón, Javier Pemán, Miguel Gobernado, Angel Viudes, Ana Espinel-Ingroff
  • Susceptibility
    In Vitro Effects of Resveratrol on the Viability and Infectivity of the Microsporidian Encephalitozoon cuniculi
    José Leiro, Ernesto Cano, Florencio M. Ubeira, Francisco Orallo, Manuel L. Sanmartín
  • Susceptibility
    Real-Time PCR for Dihydrofolate Reductase Gene Single-Nucleotide Polymorphisms in Plasmodium vivax Isolates
    Sara Brega, Frédérique de Monbrison, Carlo Severini, Rachanee Udomsangpetch, Inge Sutanto, Paul Ruckert, François Peyron, Stéphane Picot
  • Susceptibility
    Detection and Susceptibility Testing of Hypermutable Pseudomonas aeruginosa Strains with the Etest and Disk Diffusion
    Maria D. Maciá, Nuria Borrell, José L. Pérez, Antonio Oliver
  • Susceptibility
    In Vitro Activities of a Novel Cephalosporin, CB-181963 (CAB-175), against Methicillin-Susceptible or -Resistant Staphylococcus aureus and Glycopeptide-Intermediate Susceptible Staphylococci
    Vanthida Huang, William J. Brown, Michael J. Rybak
  • Susceptibility
    In Vitro Antifungal Susceptibilities of Uncommon Basidiomycetous Yeasts
    Carolina Serena, Francisco Javier Pastor, Montserrat Ortoneda, Javier Capilla, Nicole Nolard, Josep Guarro
  • Susceptibility
    In Vitro Interactions of Approved and Novel Drugs against Paecilomyces spp
    Montserrat Ortoneda, Javier Capilla, F. Javier Pastor, Isabel Pujol, Clara Yustes, Carolina Serena, Josep Guarro
  • Susceptibility
    In Vitro Susceptibilities of Madurella mycetomatis to Itraconazole and Amphotericin B Assessed by a Modified NCCLS Method and a Viability-Based 2,3-Bis(2-Methoxy-4-Nitro-5- Sulfophenyl)-5-[(Phenylamino)Carbonyl]-2H- Tetrazolium Hydroxide (XTT) Assay
    Abdalla O. A. Ahmed, Wendy W. J. van de Sande, Wim van Vianen, Alex van Belkum, Ahmed H. Fahal, Henri A. Verbrugh, Irma A. J. M. Bakker-Woudenberg
  • Susceptibility
    Dihydroethanoanthracene Derivatives as In Vitro Malarial Chloroquine Resistance Reversal Agents
    Julie Millet, Marylin Torrentino-Madamet, Sandrine Alibert, Christophe Rogier, Christiane Santelli-Rouvier, Joel Mosnier, Eric Baret, Jacques Barbe, Daniel Parzy, Bruno Pradines
  • Susceptibility
    In Vitro Activities of Iodonium Salts against Oral and Dental Anaerobes
    Ellie J. C. Goldstein, Diane M Citron, Yumi Warren, C. Vreni Merriam, Kerin Tyrrell, Helen Fernandez, Ukkiramapandian Radhakrishnan, Peter J. Stang, Georg Conrads
  • Susceptibility
    In Vitro and Bactericidal Activities of ABT-492, a Novel Fluoroquinolone, against Gram-Positive and Gram-Negative Organisms
    Laurel S. Almer, Jennifer B. Hoffrage, Erika L. Keller, Robert K. Flamm, Virginia D. Shortridge

Clinical Therapeutics

  • Clinical Therapeutics
    Optimizing Pharmacodynamic Target Attainment Using the MYSTIC Antibiogram: Data Collected in North America in 2002
    Joseph L. Kuti, Charles H. Nightingale, David P. Nicolau
  • Clinical Therapeutics
    Impact of Fluconazole Prophylaxis on Cortisol Levels in Critically Ill Surgical Patients
    Shelley S. Magill, Thanyawee Puthanakit, Sandra M. Swoboda, Kathryn A. Carson, Roberto Salvatori, Pamela A. Lipsett, Craig W. Hendrix
  • Clinical Therapeutics
    Antibacterial Effects of Amoxicillin-Clavulanate against Streptococcus pneumoniae and Haemophilus influenzae Strains for Which MICs Are High, in an In Vitro Pharmacokinetic Model
    Alasdair P. MacGowan, Alan R. Noel, Chris A. Rogers, Karen E. Bowker
  • Clinical Therapeutics
    No Findings of Dental Defects in Children Treated with Minocycline
    Antonio Cascio, Chiara Di Liberto, Matteo D'Angelo, Chiara Iaria, Francesco Scarlata, Lucina Titone, Giuseppina Campisi
  • Clinical Therapeutics
    Comparison of Artesunate and Chloroquine Activities against Plasmodium vivax Gametocytes
    Mathieu Nacher, Udomsak Silachamroon, Pratap Singhasivanon, Polrat Wilairatana, Weerapong Phumratanaprapin, Arnaud Fontanet, Sornchai Looareesuwan

Biologic Response Modifiers

  • Biologic Response Modifiers
    Effects of Fluoroquinolones on the Migration of Human Phagocytes through Chlamydia pneumoniae-Infected and Tumor Necrosis Factor Alpha-Stimulated Endothelial Cells
    Silvia M. Uriarte, Robert E. Molestina, Richard D. Miller, Jorge Bernabo, Alicia Farinati, Kumiko Eiguchi, Julio A. Ramirez, James T. Summersgill

Letters

  • LETTERS TO THE EDITOR
    Pharmacokinetics of Oral Valganciclovir and Intravenous Ganciclovir Administered to Prevent Cytomegalovirus Disease in an Adult Patient Receiving Small-Intestine Transplantation
    Jesús Fortún Abete, Pilar Martín-Dávila, S. Moreno, Yolanda Quijano, Emilio de Vicente, Leonor Pou
  • LETTERS TO THE EDITOR
    Study Design Questions in Treatment of Children with Acute Otitis Media
    Alejandro Hoberman, Jack L. Paradise
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Antimicrobial Agents and Chemotherapy: 48 (7)

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volume 48, issue 7
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  • Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
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