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Table of Contents

August 1, 2004; Volume 48,Issue 8

Minireviews

  • Minireview
    Hazard Ratio in Clinical Trials
    Spotswood L. Spruance, Julia E. Reid, Michael Grace, Matthew Samore

Clinical Therapeutics

  • Clinical Therapeutics
    Comparative Effects of Ciprofloxacin and Ceftazidime on Cytokine Production in Patients with Severe Sepsis Caused by Gram-Negative Bacteria
    C. A. Gogos, A. Skoutelis, A. Lekkou, E. Drosou, I. Starakis, M. N. Marangos, H. P. Bassaris
  • Clinical Therapeutics
    Population Pharmacokinetics of Daptomycin
    Barry Dvorchik, Robert D. Arbeit, Julia Chung, Susan Liu, William Knebel, Helen Kastrissios
  • Clinical Therapeutics
    Effects of an Antibiotic Cycling Program on Antibiotic Prescribing Practices in an Intensive Care Unit
    Liana R. Merz, David K. Warren, Marin H. Kollef, Victoria J. Fraser
  • Clinical Therapeutics
    Pilot Randomized Double-Blind Trial of Treatment of Mycobacterium ulcerans Disease (Buruli Ulcer) with Topical Nitrogen Oxides
    R. Phillips, O. Adjei, S. Lucas, N. Benjamin, M. Wansbrough-Jones
  • Clinical Therapeutics
    Effect of Amoxicillin Use on Oral Microbiota in Young Children
    D. Ready, H. Lancaster, F. Qureshi, R. Bedi, P. Mullany, M. Wilson
  • Clinical Therapeutics
    Pharmacokinetics of Intravenous Itraconazole in Stable Hemodialysis Patients
    John F. Mohr, Kevin W. Finkel, John H. Rex, Jose R. Rodriguez, Gerhard J. Leitz, Luis Ostrosky-Zeichner

Mechanisms of Resistance

  • Mechanisms of Resistance
    Multiple Outbreaks of Nosocomial Salmonellosis in Russia and Belarus Caused by a Single Clone of Salmonella enterica Serovar Typhimurium Producing an Extended-Spectrum β-Lactamase
    M. Edelstein, M. Pimkin, T. Dmitrachenko, V. Semenov, N. Kozlova, D. Gladin, A. Baraniak, L. Stratchounski
  • Mechanisms of Resistance
    DNA Sequence Analysis of Regions Surrounding blaCMY-2 from Multiple Salmonella Plasmid Backbones
    W. P. Giles, A. K. Benson, M. E. Olson, R. W. Hutkins, J. M. Whichard, P. L. Winokur, P. D. Fey
  • Mechanisms of Resistance
    Molecular Characterization of a Cephamycin-Hydrolyzing and Inhibitor-Resistant Class A β-Lactamase, GES-4, Possessing a Single G170S Substitution in the Ω-Loop
    Jun-ichi Wachino, Yohei Doi, Kunikazu Yamane, Naohiro Shibata, Tetsuya Yagi, Takako Kubota, Yoshichika Arakawa
  • Mechanisms of Resistance
    Rapid Real-Time PCR Genotyping of Mutations Associated with Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum
    Alisa P. Alker, Victor Mwapasa, Steven R. Meshnick
  • Mechanisms of Resistance
    Modulation of Fibronectin Adhesins and Other Virulence Factors in a Teicoplanin-Resistant Derivative of Methicillin-Resistant Staphylococcus aureus
    Adriana Renzoni, Patrice Francois, Dongmei Li, William L. Kelley, Daniel P. Lew, Pierre Vaudaux, Jacques Schrenzel
  • Mechanisms of Resistance
    Activities of Different Fluoroquinolones against Bacillus anthracis Mutants Selected In Vitro and Harboring Topoisomerase Mutations
    Patrick Grohs, Isabelle Podglajen, Laurent Gutmann
  • Mechanisms of Resistance
    Impact of Specific pbp5 Mutations on Expression of β-Lactam Resistance in Enterococcus faecium
    Louis B. Rice, Samuel Bellais, Lenore L. Carias, Rebecca Hutton-Thomas, Robert A. Bonomo, Patrick Caspers, Malcolm G. P. Page, Laurent Gutmann
  • Mechanisms of Resistance
    Comparison of Gene Expression Profiles of Candida albicans Azole-Resistant Clinical Isolates and Laboratory Strains Exposed to Drugs Inducing Multidrug Transporters
    Mahir Karababa, Alix T. Coste, Bénédicte Rognon, Jacques Bille, Dominique Sanglard
  • Mechanisms of Resistance
    Novel Polymorphisms in mec Genes and a New mec Complex Type in Methicillin-Resistant Staphylococcus aureus Isolates Obtained in Rural Wisconsin
    Sanjay K. Shukla, Srinivas V. Ramaswamy, Jennifer Conradt, Mary E. Stemper, Robert Reich, Kurt D. Reed, Edward A. Graviss
  • Mechanisms of Resistance
    Emergence in Italy of a Neisseria meningitidis Clone with Decreased Susceptibility to Penicillin
    Paola Stefanelli, Cecilia Fazio, Arianna Neri, Tonino Sofia, Paola Mastrantonio
  • Mechanisms of Resistance
    Lack of Evidence that DNA in Antibiotic Preparations Is a Source of Antibiotic Resistance Genes in Bacteria from Animal or Human Sources
    Susanna K. P. Lau, Patrick C. Y. Woo, Amanda P. C. To, Alexson T. K. Lau, Kwok-yung Yuen
  • Mechanisms of Resistance
    High Prevalence of Extended-Spectrum β-Lactamase-Producing Strains among Blood Isolates of Enterobacter spp. Collected in a Tertiary Hospital during an 8-Year Period and Their Antimicrobial Susceptibility Patterns
    Hyunjoo Pai, Jung Yun Hong, Jeong-Hum Byeon, Yun-Kyung Kim, Hoan-Jong Lee
  • Mechanisms of Resistance
    In Vitro Activities of Telithromycin, Linezolid, and Quinupristin-Dalfopristin against Streptococcus pneumoniae with Macrolide Resistance Due to Ribosomal Mutations
    David J. Farrell, Ian Morrissey, Sarah Bakker, Sylvie Buckridge, David Felmingham
  • Mechanisms of Resistance
    CMY-13, a Novel Inducible Cephalosporinase Encoded by an Escherichia coli Plasmid
    V. Miriagou, L. S. Tzouvelekis, L. Villa, E. Lebessi, A. C. Vatopoulos, A. Carattoli, E. Tzelepi
  • Mechanisms of Resistance
    Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis
    Maria Rosalia Pasca, Paola Guglierame, Fabio Arcesi, Marco Bellinzoni, Edda De Rossi, Giovanna Riccardi
  • Mechanisms of Resistance
    Extended-Spectrum-Cephalosporin Resistance in Salmonella enterica Isolates of Animal Origin
    Jeffrey T. Gray, Laura L. Hungerford, Paula J. Fedorka-Cray, Marcia L. Headrick
  • Mechanisms of Resistance
    High Prevalence of the ermB Gene among Erythromycin-Resistant Streptococcus pneumoniae Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin
    Michael Kresken, Beate Henrichfreise, Simone Bagel, Johannes Brauers, Bernd Wiedemann
  • Mechanisms of Resistance
    Role of β-Lactamases and Porins in Resistance to Ertapenem and Other β-Lactams in Klebsiella pneumoniae
    George A. Jacoby, Debra M. Mills, Nancy Chow

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Unraveling the Mode of Action of the Antimalarial Choline Analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae
    Rodolphe Roggero, Rachel Zufferey, Mihaela Minca, Eric Richier, Michele Calas, Henri Vial, Choukri Ben Mamoun
  • Mechanisms of Action: Physiological Effects
    Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling
    Bernd Hutter, Christoph Schaab, Sebastian Albrecht, Matthias Borgmann, Nina A. Brunner, Christoph Freiberg, Karl Ziegelbauer, Charles O. Rock, Igor Ivanov, Hannes Loferer
  • Mechanisms of Action: Physiological Effects
    Antibiotic-Inducible Promoter Regulated by the Cell Envelope Stress-Sensing Two-Component System LiaRS of Bacillus subtilis
    Thorsten Mascher, Sara L. Zimmer, Terry-Ann Smith, John D. Helmann
  • Mechanisms of Action: Physiological Effects
    Ribosomal P0 Protein Domain Involved in Selectivity of Antifungal Sordarin Derivatives
    C. Santos, M. A. Rodríguez-Gabriel, M. Remacha, J. P. G. Ballesta
  • Mechanisms of Action: Physiological Effects
    Role of Positional Hydrophobicity in the Leishmanicidal Activity of Magainin 2
    Esther Guerrero, José María Saugar, Katsumi Matsuzaki, Luis Rivas
  • Mechanisms of Action: Physiological Effects
    Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis
    Graham S. Timmins, Sharon Master, Frank Rusnak, Vojo Deretic
  • Mechanisms of Action: Physiological Effects
    Possible Mechanism of Miltefosine-Mediated Death of Leishmania donovani
    Navin K. Verma, Chinmoy S. Dey
  • Mechanisms of Action: Physiological Effects
    Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity
    Karen M. Grant, Morag H. Dunion, Vanessa Yardley, Alexios-Leandros Skaltsounis, Doris Marko, Gerhard Eisenbrand, Simon L. Croft, Laurent Meijer, Jeremy C. Mottram
  • Mechanisms of Action: Physiological Effects
    Regulation of the Expression of Cell Wall Stress Stimulon Member Gene msrA1 in Methicillin-Susceptible or -Resistant Staphylococcus aureus
    Roger Pechous, Nagender Ledala, Brian J. Wilkinson, Radheshyam K. Jayaswal

Antiviral Agents

  • Antiviral Agents
    Zidovudine, Lamivudine, and Abacavir Have Different Effects on Resting Cells Infected with Human Immunodeficiency Virus In Vitro
    Jesús Saavedra-Lozano, Cynthia C. McCoig, Yanying Cao, Ellen S. Vitetta, Octavio Ramilo
  • Antiviral Agents
    Inhibition of Hepatitis C Virus Replication by Arsenic Trioxide
    Der-Ren Hwang, Yuan-Chin Tsai, Jin-Ching Lee, Kuo-Kuei Huang, Ren-Kuo Lin, Chia-Hua Ho, Jeng-Min Chiou, Ying-Ting Lin, John T. A. Hsu, Chau-Ting Yeh
  • Antiviral Agents
    Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir
    Dean Hickman, Sudthida Vasavanonda, George Nequist, Lynn Colletti, Warren M. Kati, Richard Bertz, Ann Hsu, Dale J. Kempf
  • Antiviral Agents
    Nucleotide and Amino Acid Polymorphisms at Drug Resistance Sites in Non-B-Subtype Variants of Human Immunodeficiency Virus Type 1
    Dan Turner, Bluma Brenner, Daniela Moisi, Mervi Detorio, Raymond Cesaire, Takashi Kurimura, Haruyo Mori, Max Essex, Shlomo Maayan, Mark A. Wainberg
  • Antiviral Agents
    Distribution of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Mutation Patterns in 4,183 Persons Undergoing Genotypic Resistance Testing
    Soo-Yon Rhee, Tommy Liu, Jaideep Ravela, Matthew J. Gonzales, Robert W. Shafer
  • Antiviral Agents
    A Lipid-Peptide Microbicide Inactivates Herpes Simplex Virus
    Charles E. Isaacs, Jun Hua Jia, Weimin Xu

Susceptibility

  • Susceptibility
    In Vitro Activities of ME1036 (CP5609), a Novel Parenteral Carbapenem, against Methicillin-Resistant Staphylococci
    Mizuyo Kurazono, Takashi Ida, Keiko Yamada, Yoko Hirai, Takahisa Maruyama, Eiki Shitara, Minoru Yonezawa
  • Susceptibility
    Synergy of Daptomycin with Oxacillin and Other β-Lactams against Methicillin-Resistant Staphylococcus aureus
    Kenneth H. Rand, Herbert J. Houck
  • Susceptibility
    Novel Azasterols as Potential Agents for Treatment of Leishmaniasis and Trypanosomiasis
    Silvia Orenes Lorente, Juliany C. F. Rodrigues, Carmen Jiménez Jiménez, Miranda Joyce-Menekse, Carlos Rodrigues, Simon L. Croft, Vanessa Yardley, Kate de Luca-Fradley, Luis M. Ruiz-Pérez, Julio Urbina, Wanderley de Souza, Dolores González Pacanowska, Ian H. Gilbert
  • Susceptibility
    Relationship between Triclosan and Susceptibilities of Bacteria Isolated from Hands in the Community
    Allison E. Aiello, Bonnie Marshall, Stuart B. Levy, Phyllis Della-Latta, Elaine Larson
  • Susceptibility
    Comparison of the Susceptibilities of Burkholderia pseudomallei to Meropenem and Ceftazidime by Conventional and Intracellular Methods
    T. J. J. Inglis, F. Rodrigues, P. Rigby, R. Norton, B. J. Currie
  • Susceptibility
    Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin
    Stephanie J. Schrag, Lesley McGee, Cynthia G. Whitney, Bernard Beall, Allen S. Craig, Miriam E. Choate, James H. Jorgensen, Richard R. Facklam, Keith P. Klugman
    and the Active Bacterial Core Surveillance Team
  • Susceptibility
    Doripenem versus Pseudomonas aeruginosa In Vitro: Activity against Characterized Isolates, Mutants, and Transconjugants and Resistance Selection Potential
    Shazad Mushtaq, Yigong Ge, David M. Livermore
  • Susceptibility
    In Vitro Activities of Ravuconazole and Four Other Antifungal Agents against Fluconazole-Resistant or -Susceptible Clinical Yeast Isolates
    Manuel Cuenca-Estrella, Alicia Gomez-Lopez, Emilia Mellado, Guillermo Garcia-Effron, Juan L. Rodriguez-Tudela
  • Susceptibility
    Omiganan Pentahydrochloride (MBI 226), a Topical 12-Amino-Acid Cationic Peptide: Spectrum of Antimicrobial Activity and Measurements of Bactericidal Activity
    Helio S. Sader, Kelley A. Fedler, Robert P. Rennie, Shelley Stevens, Ronald N. Jones
  • Susceptibility
    Inhibitory Activities of Colicins against Escherichia coli Strains Responsible for Postweaning Diarrhea and Edema Disease in Swine
    Chad H. Stahl, Todd R. Callaway, Leslie M. Lincoln, Steven M. Lonergan, Kenneth J. Genovese
  • Susceptibility
    In Vitro Activity and Potency of an Intravenously Injected Antimicrobial Peptide and Its dl Amino Acid Analog in Mice Infected with Bacteria
    Amir Braunstein, Niv Papo, Yechiel Shai
  • Susceptibility
    In Vitro Killing of Mycobacterium ulcerans by Acidified Nitrite
    R. Phillips, S. Kuijper, N. Benjamin, M. Wansbrough-Jones, M. Wilks, A. H. J. Kolk
  • Susceptibility
    Activities of Doripenem (S-4661) against Drug-Resistant Clinical Pathogens
    Ronald N. Jones, Holly K. Huynh, Douglas J. Biedenbach
  • Susceptibility
    Effect of pH on the In Vitro Activities of Amphotericin B, Itraconazole, and Flucytosine against Aspergillus Isolates
    D. T. A. Te Dorsthorst, J. W. Mouton, C. J. P. van den Beukel, H. A. L. van der Lee, J. F. G. M. Meis, P. E. Verweij
  • Susceptibility
    In Vitro Activities of the Newer Quinolones Garenoxacin, Gatifloxacin, and Gemifloxacin against Human Mycoplasmas
    S. Pereyre, H. Renaudin, C. Bébéar, C. M. Bébéar
  • Susceptibility
    Remarkable Increase in Central Japan in 2001-2002 of Neisseria gonorrhoeae Isolates with Decreased Susceptibility to Penicillin, Tetracycline, Oral Cephalosporins, and Fluoroquinolones
    Masayasu Ito, Mitsuru Yasuda, Shigeaki Yokoi, Shin-ichi Ito, Yoshito Takahashi, Satoshi Ishihara, Shin-ichi Maeda, Takashi Deguchi
  • Susceptibility
    Antianaerobic Activity of a Novel Fluoroquinolone, WCK 771, Compared to Those of Nine Other Agents
    Mihaela Peric, Michael R. Jacobs, Peter C. Appelbaum
  • Susceptibility
    Susceptibility of Chlamydia trachomatis to Excipients Commonly Used in Topical Microbicide Formulations
    M. F. Lampe, L. C. Rohan, M. C. Skinner, W. E. Stamm

Experimental Therapeutics

  • Experimental Therapeutics
    Cellular Pharmacokinetics and Pharmacodynamics of the Glycopeptide Antibiotic Oritavancin (LY333328) in a Model of J774 Mouse Macrophages
    Françoise Van Bambeke, Stéphane Carryn, Cristina Seral, Hugues Chanteux, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens
  • Experimental Therapeutics
    Impact of Cethromycin (ABT-773) Therapy on Microbiological, Histologic, Immunologic, and Respiratory Indices in a Murine Model of Mycoplasma pneumoniae Lower Respiratory Infection
    Ana María Ríos, Asunción Mejías, Susana Chávez-Bueno, Mónica Fonseca-Aten, Kathy Katz, Jeanine Hatfield, Ana María Gómez, Hasan S. Jafri, George H. McCracken, Octavio Ramilo, Robert Doug Hardy
  • Experimental Therapeutics
    Therapeutic Efficacy of “Nubiotics” against Burn Wound Infection by Pseudomonas aeruginosa
    Roderic M. K. Dale, Glen Schnell, Jonathan P. Wong
  • Experimental Therapeutics
    Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis
    Ramesh Jayaram, Radha. K. Shandil, Sheshagiri Gaonkar, Parvinder Kaur, B. L. Suresh, B. N. Mahesh, R. Jayashree, Vrinda Nandi, Sowmya Bharath, E. Kantharaj, V. Balasubramanian
  • Experimental Therapeutics
    Pharmacodynamics of Telavancin (TD-6424), a Novel Bactericidal Agent, against Gram-Positive Bacteria
    Sharath S. Hegde, Noe Reyes, Tania Wiens, Nicole Vanasse, Robert Skinner, Julia McCullough, Koné Kaniga, John Pace, Roger Thomas, Jeng-Pyng Shaw, Glen Obedencio, J. Kevin Judice
  • Experimental Therapeutics
    Susceptibility to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Increased Fluconazole Efficacy against Experimental Endocarditis Due to Candida albicans
    Michael R. Yeaman, Darwin Cheng, Bhavesh Desai, Leon I. Kupferwasser, Yan-Qiong Xiong, Kimberly D. Gank, John E. Edwards, Arnold S. Bayer
  • Experimental Therapeutics
    Lack of Activity of Orally Administered Clofazimine against Intracellular Mycobacterium tuberculosis in Whole-Blood Culture
    Ernestas Janulionis, Carolina Sofer, Ho-Yeon Song, Robert S. Wallis
  • Experimental Therapeutics
    Effect of Granulocyte Colony-Stimulating Factor Combination Therapy on Efficacy of Posaconazole (SCH56592) in an Inhalation Model of Murine Pulmonary Aspergillosis
    Andriani C. Patera, Frederick Menzel, Craig Jackson, Joan K. Brieland, Judy Halpern, Roberta Hare, Anthony Cacciapuoti, David Loebenberg
  • Experimental Therapeutics
    Temporin A Soaking in Combination with Intraperitoneal Linezolid Prevents Vascular Graft Infection in a Subcutaneous Rat Pouch Model of Infection with Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides
    Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Giuseppina D'Amato, Wojciech Kamysz, Federico Mocchegiani, Valerio Sisti, Carmela Silvestri, Jerzy Łukasiak, Marco Rocchi, Vittorio Saba, Giorgio Scalise

Pharmacology

  • Pharmacology
    Disposition of Artesunate and Dihydroartemisinin after Administration of Artesunate Suppositories in Children from Papua New Guinea with Uncomplicated Malaria
    Harin A. Karunajeewa, Kenneth F. Ilett, Kitiya Dufall, Adedayo Kemiki, Moses Bockarie, Michael P. Alpers, P. Hugh Barrett, Paolo Vicini, Timothy M. E. Davis

Biologic Response Modifiers

  • Biologic Response Modifiers
    Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice
    Philip Lake, Jeffrey DeLeo, Franklin Cerasoli, Lennart Logdberg, Marla Weetall, Dean Handley

Chemistry; Biosynthesis

  • Chemistry; Biosynthesis
    1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)
    Xin He, Anne McElwee Reeve, Umesh R. Desai, Glen E. Kellogg, Kevin A. Reynolds
  • Chemistry; Biosynthesis
    Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda
    Sabrina Krief, Marie-Thérèse Martin, Philippe Grellier, John Kasenene, Thierry Sévenet

Letters

  • LETTERS TO THE EDITOR
    nimE Gene in a Metronidazole-Susceptible Veillonella sp. Strain
    H. Marchandin, H. Jean-Pierre, J. Campos, L. Dubreuil, C. Teyssier, E. Jumas-Bilak
  • LETTERS TO THE EDITOR
    Spectrum of pncA Mutations in Multidrug-Resistant Mycobacterium tuberculosis Isolates Obtained in Latvia
    Tatjana Tracevska, Inta Jansone, Viesturs Baumanis, Anda Nodieva, Olgerts Marga, Girts Skenders
  • LETTERS TO THE EDITOR
    Challenges in Designing Animal Studies To Detect Antagonism of Polyene Activity
    Russell E. Lewis, Dimitrios P. Kantoyiannis

Author's Correction

  • AUTHOR'S CORRECTION
    Killing by Ampicillin and Ofloxacin Induces Overlapping Changes in Escherichia coli Transcription Profile
    Niilo Kaldalu, Rui Mei, Kim Lewis

Errata

  • Erratum
    Field Evaluation of a Novel Colorimetric Method—Double-Site Enzyme-Linked Lactate Dehydrogenase Immunodetection Assay—To Determine Drug Susceptibilities of Plasmodium falciparum Clinical Isolates from Northwestern Thailand
    Alan Brockman, Sittaporn Singlam, Lucy Phiaphun, Sornchai Looareesuwan, Nicholas J. White, François Nosten
  • Erratum
    Sulfadoxine-Pyrimethamine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi
    Karen Hayton, Lisa C. Ranford-Cartwright, David Walliker
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Antimicrobial Agents and Chemotherapy: 48 (8)

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volume 48, issue 8
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