Article Figures & Data
Figures
- FIG. 1.
Mean CFU of M. pneumoniae (Mp) in BAL cultures of infected mice treated with either cethromycin (25 mg/kg/day subcutaneously) or placebo for 10 days (therapy was started 1 day after infection). Error bars represent standard deviations. *, P < 0.05; ***, P < 0.001. n = 5 to 10 mice per cethromycin treatment group and 5 to 15 mice per placebo group.
- FIG. 2.
Median HPS of mice infected with M. pneumoniae (Mp) and treated with either cethromycin or placebo. Error bars represent 75th to 25th percentiles. *, P < 0.05; **, P < 0.01. n = 5 to 10 mice per cethromycin treatment group and 5 to 15 mice per placebo group.
- FIG. 3.
(a to j) Mean and median cytokine and chemokine concentrations in BAL fluid of mice infected with M. pneumoniae (Mp) and treated with either cethromycin or placebo. Error bars represent standard deviations when variables have a normal distribution and 75th to 25th percentiles when variables do not have a normal distribution. *, P < 0.05; **, P < 0.01; ***, P < 0.001. n = 5 to 10 mice per cethromycin treatment group and 5 to 15 mice per placebo group.
- FIG. 4.
Median Penh of mice infected with M. pneumoniae (Mp) and treated with either cethromycin or placebo. Error bars represent 75th to 25th percentiles. *, P < 0.05. n = 5 to 10 mice per cethromycin treatment group and 5 to 15 mice per placebo group.
- FIG. 5.
Mean post-methacholine exposure Penh of mice infected with M. pneumoniae (Mp) and treated with either cethromycin or placebo. Error bars represent standard deviations. *, P < 0.05. n = 5 to 10 mice per cethromycin treatment group and 5 to 15 mice per placebo group.
Tables
- TABLE 2.
Correlations of cytokines and chemokines in BAL samples at day 4
Cytokine or chemokine Correlation with: M. pneumoniae cultures HPS AOa AHRb Cethromycin therapy r P n r P n r P n r P n r P n IL-1β 0.2 0.4 15 0.5 0.05 19 0.3 0.2 16 0.6 0.02 16 −0.5 0.03 19 IL-2 0.3 0.3 15 0.5 0.01 19 0.4 0.2 16 0.4 0.1 16 −0.4 0.09 19 TNF-α 0.2 0.3 19 0.7 <0.001 23 0.4 0.09 20 0.3 0.2 20 −0.6 0.005 23 IL-12 0.5 0.06 15 0.5 0.02 19 0.6 0.01 16 0.4 0.2 16 −0.7 0.002 19 IFN-γ 0.7 0.004 15 0.7 <0.001 19 0.7 <0.001 16 0.6 0.01 16 −0.6 0.008 19 IL-4 0.03 0.9 15 0.4 0.1 19 0.3 0.2 16 0.4 0.1 16 −0.1 0.5 19 GM-CSF 0.02 0.9 15 0.3 0.1 19 0.08 0.7 16 0.3 0.2 16 0.05 0.8 19 IL-8 0.2 0.4 19 0.3 0.1 23 0.4 0.1 20 0.4 0.04 20 −0.4 0.003 23 MCP-1 0.3 0.3 19 0.6 0.001 23 0.6 0.005 20 0.4 0.07 20 −0.8 <0.001 23 MIP-1α 0.2 0.3 19 0.6 0.007 22 0.5 0.05 19 0.2 0.3 19 −0.8 <0.001 22 - TABLE 3.
Correlations of cytokines and chemokines in BAL samples at day 4
Cytokine or chemokine Correlation with: IL-1β IL-2 TNF-α IL-12 INF-γ r P n r P n r P n r P n r P n IL-1β 0.7 0.002 19 0.4 0.06 19 0.4 0.06 19 0.5 0.01 19 IL-2 0.5 0.04 19 0.5 0.01 19 0.5 0.02 19 TNF-α 0.2 0.3 19 0.5 0.01 19 IL-12 0.7 0.001 19 MCP-1 0.07 0.7 19 0.3 0.1 19 0.5 0.01 19 0.8 <0.001 19 0.8 <0.001 19 MIP-1α 0.3 0.2 19 0.3 0.2 19 0.5 0.02 19 0.7 <0.001 19 0.6 0.01 19
