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Mechanisms of Action: Physiological Effects

Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis

Graham S. Timmins, Sharon Master, Frank Rusnak, Vojo Deretic
Graham S. Timmins
1College of Pharmacy, Toxicology Program
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  • For correspondence: gtimmins@salud.unm.edu
Sharon Master
2Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131
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Frank Rusnak
3Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905
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Vojo Deretic
2Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131
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DOI: 10.1128/AAC.48.8.3006-3009.2004
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Article Information

DOI 
https://doi.org/10.1128/AAC.48.8.3006-3009.2004
PubMed 
15273113

Published By 
American Society for Microbiology Journals
History 
  • Received January 7, 2004
  • Returned for modification March 8, 2004
  • Accepted April 2, 2004
  • Published online July 23, 2004.

Copyright & Usage 
Copyright © 2004 American Society for Microbiology

Author Information

  1. Graham S. Timmins1*,
  2. Sharon Master2,
  3. Frank Rusnak3† and
  4. Vojo Deretic2
  1. 1College of Pharmacy, Toxicology Program
  2. 2Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131
  3. 3Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905
  • ↵* Corresponding author. Mailing address: College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131. Phone: (505) 272-4103. Fax: (505) 272-6749. E-mail: gtimmins{at}salud.unm.edu .
  • ↵† Deceased.

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Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis
Graham S. Timmins, Sharon Master, Frank Rusnak, Vojo Deretic
Antimicrobial Agents and Chemotherapy Jul 2004, 48 (8) 3006-3009; DOI: 10.1128/AAC.48.8.3006-3009.2004

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Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis
Graham S. Timmins, Sharon Master, Frank Rusnak, Vojo Deretic
Antimicrobial Agents and Chemotherapy Jul 2004, 48 (8) 3006-3009; DOI: 10.1128/AAC.48.8.3006-3009.2004
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KEYWORDS

antitubercular agents
Bacterial Proteins
isoniazid
Mycobacterium tuberculosis
nitric oxide
Oxidoreductases
Tyrosine

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