Article Figures & Data
Figures
- FIG. 1.
Reductions of parasite burdens in spleens and livers of treated hamsters in relation to those in the control (untreated) groups. The standard deviation (bars) was calculated by comparing individual data for the treated animals with the average value for the control group. *, statistically significant differences; Mic., microspheres.
- FIG. 2.
Kinetics of antibody responses in untreated control animals (▪) and animals treated with AMB microspheres containing 40 mg of AMB/kg (◊) or empty microspheres (•) given on days 69, 71, and 73 days (week 11) postinfection (P.I.) by the intracardiac route. Animals were infected with 107 stationary-phase promastigotes of L. infantum, and serum samples were taken weekly for 21 weeks. Bars, standard deviations; *, significant difference between the control group and the group treated with AMB microspheres; O.D., optical density.
- FIG. 3.
AMB concentration (average values and standard errors [bars]) versus time in serum (A), spleen (B), and liver (C) after the injection of AMB microspheres or AMB-Doc with a dose of 2 mg of AMB/kg by the intracardiac route. The P values are indicated for the points with significant differences.
Tables
- TABLE 1.
Mortality in hamsters during the 48 h after administration of a single dose of AMB
AMB dose (mg/kg) No. of animals that died/total no. of animals tested (%) AMB-Doc AMB microspheres Infected Healthy Infected Healthy 0 (untreated) 0/6 (0) 0/6 (0) 0/6 (0) 0/6 (0) 2.5 0/6 (0) 0/6 (0) 0/6 (0) 0/6 (0) 5 6/6 (100) 0/6 (0) 0/6 (0) 0/6 (0) 10 0/6 (0)a 0/6 (0) 0/6 (0) 20 6/6 (100) 0/6 (0) 0/6 (0) 40 0/6 (0) 0/6 (0) ↵ a All the animals showed uncoordinated movements or abnormal behavior.
